DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33158 and eef2a.1

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001038626.2	Gene:	eef2a.1 / 792182	ZFINID:	ZDB-GENE-050522-500	Length:	854	Species:	Danio rerio

Alignment Length:	1040	Identity:	303/1040 - (29%)
Similarity:	473/1040 - (45%)	Gaps:	243/1040 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQERGITMKSSSISLYY 79
            ::..:||:.::...||||:||.|.||:..||:|...||:.|::|.|.|||||.||:||::||::|
Zfish    15 KKSNIRNMSVIGAFDHGKSTLTDWLVSEAGIVSSARAGETRFMDTRRDEQERCITIKSTAISIFY 79

  Fly    80 QEAE-------EMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLR 137
            :.||       |......:|:|||||||||||||||:.|:|:.|||::|||.|.||..||...||
Zfish    80 ELAEKDLAFIKECKDGSGFLLNLIDSPGHVDFSSEVTAALRITDGALLVVDCVSGVCLQTETVLR 144

  Fly   138 QIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKKDNY 202
            |...|::||||::||:||.:||.|:.|.:.|....:::|:||..: |.:|.|
Zfish   145 QAIGERIKPVLMINKMDRALLELQLVPEELYQIFQRIVEKVNVTI-STYAED------------- 195

  Fly   203 ESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRL---------EMSRK--DLEN 256
                |:.....:...|..||:.|.|...||||:::.||.:|.|:.         |..:|  |:..
Zfish   196 ----EKGPMGNVMIDPVIGNLAFGSGLHGWAFTLKQFAELYVKKFAGKAQLGPEEYIKKVEDMIK 256

  Fly   257 VLWGDFYYNS---KKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAEKLGLK 318
            .||||.|::|   |..|:......|.....||..||:.|:.::|.|...| |::...:.||:|:|
Zfish   257 RLWGDSYFDSTTGKFSESATSPDGKKLPRTFVHLVLDPIFKVFDAIMNFK-KEETVKLIEKMGIK 320

  Fly   319 LATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLSSLPPE 383
            |...| :..:.|:.:|||:..|||..:::|.|:..|:|.|......|.: |||..        |.
Zfish   321 LDVED-KEKEGKILLKAVMRCWLPAGEALLQMITIHLPSPVTAQIYRCE-LLYEG--------PG 375

  Fly   384 TLELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQSE 448
            ..|......:||..:. ::.::|||.|.
Zfish   376 DDEAAMGIKNCDPKAP-LMMYISKMIPT------------------------------------- 402

  Fly   449 QAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMELFNLSPKHDPR 513
                                            .::..|.||.|||||.:..|:.:..:.|...|
Zfish   403 --------------------------------SDKGCFYAFGRVFSGCVSTGLNVRIMGPNFTP- 434

  Fly   514 QPTHRKEGEAPYASRVTIGDLY--------MFMGGELQLLDEVPAGNIVGIGGLESHIVKTATLS 570
               .:|:            |||        :.||..::.:::||.|||||:.|::..:|||.|::
Zfish   435 ---GKKD------------DLYLKPIQRTVLMMGRYVEPIEDVPCGNIVGLLGVDQFLVKTGTIT 484

  Fly   571 SSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPTGEHVITTLGE 635
            :.....:...:....:|::||::|.:.|.|:||||:|||.|.::|..:|..:..||||:|...||
Zfish   485 TFTKAYNMRVMKFSVSPVVRVSVEVMDPADLPKLVEGLKHLAKSDPMLQCIIEDTGEHIIAGAGE 549

  Fly   636 VHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAVQQTLN 700
            :|:|.|:.|||:.:|.|.:..|.|..|:|||:                   .|.||::.:.:|.|
Zfish   550 LHLEICLKDLEEDHACIPLKKSDPFASYRETV-------------------SDGSKQLCLAKTPN 595

  Fly   701 KLGTLKVIAVPLPAEAVELLE----THSEFFKELAAIPRNQLLSE--KWTALLASIKVKLIAALK 759
            |...|.:.|.||.....|.::    |.|:   |:.|  |.|.|:|  ||....|
Zfish   596 KHSRLFMKACPLADGLAEDIDKGRVTASQ---EMNA--RAQYLAENYKWEVTEA----------- 644

  Fly   760 DLQLFGLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKDFN 824
                            .:||..||...|.|||:                   |:..:.....:..
Zfish   645 ----------------RKIWCFGPEGTGPNILV-------------------DLTKRVQYLNEIK 674

  Fly   825 SSLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVCRQAFQNQ 889
            .|::.|||..:..|.||.|.|:|:.|.:.:.::.|..   ..|||  ||::.|.:.|........
Zfish   675 DSVIAGFQWATREGVLCAENMRGIRFDIHDATLTSTA---IHRGP--GQIIVATRRVLYGCQLTA 734

  Fly   890 PQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQEMR 954
            ..||..|:|...:.....::|.:|..:.||.|.:.|.....|:..:.:...|||.|||.|..::.
Zfish   735 EPRLSEPIYLVEMQCPESVIGNVYGELVRRRGVVFSESQVMGTPVYLLKAYLPVSESFGFTADLC 799

  Fly   955 KQTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKGLFVDEQV 1019
            ..|||.|..|.:|.||:::..||.                |..::....|..:|:.|||  ||.:
Zfish   800 ANTSGQAFSQCVFDHWQILPGDPM----------------DPTSKVAHIMADIRKSKGL--DEAI 846

Fly 1020 1019
Zfish 847 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	301/1035 (29%)
		EF2	20..249	CDD:206672	100/244 (41%)
		EF2_II	485..572	CDD:293913	29/94 (31%)
		EF2_snRNP_III	587..658	CDD:293918	31/70 (44%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	58/246 (24%)
		eEF2_snRNP_like_C	896..974	CDD:239763	24/77 (31%)
eef2a.1	NP_001038626.2	PTZ00416	1..854	CDD:240409	303/1040 (29%)
		EF2	20..233	CDD:206672	98/230 (43%)
		Translation_Factor_II_like	392..486	CDD:295476	33/178 (19%)
		EF2_snRNP_III	511..572	CDD:293918	27/60 (45%)
		aeEF2_snRNP_like_IV	572..744	CDD:238839	58/246 (24%)
		eEF2_snRNP_like_C	740..819	CDD:239763	24/78 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820