DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33158 and gfm1

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001073463.1	Gene:	gfm1 / 561840	ZFINID:	ZDB-GENE-061013-79	Length:	745	Species:	Danio rerio

Alignment Length:	979	Identity:	197/979 - (20%)
Similarity:	346/979 - (35%)	Gaps:	326/979 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 QQVRNICILAHVDHGKTTLADSLVASNGIISQ--RMAGK---LRYLDNRSDEQERGITMKSSSIS 76
            :::|||.|.||:|.|||||.:.::...|.|::  .:.||   ...:|:...|::||||::|::..
Zfish    39 ERIRNIGISAHIDSGKTTLTERVLYYTGRIAEMHEVRGKDGVGAIMDSMELERQRGITIQSAATY 103

  Fly    77 LYYQEAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLRQIYE 141
            ..::         ::.||:||:||||||:.||..::|:.|||::|:..|.||..||....||:..
Zfish   104 TMWK---------NHNINIIDTPGHVDFTIEVERSLRVLDGAVLVLCAVGGVQCQTVTVNRQMKR 159

  Fly   142 EQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKKDNYESAL 206
            ..:..:..:||||||    ..:|..|...|...|.| ||...:|         .|..:.|....:
Zfish   160 YSVPFLTFINKLDRL----GANPNRALQQLRTKLNQ-NAAFVNI---------PIGLEGNLRGII 210

  Fly   207 EEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRLEMSRKDLENVLWGDFYYNSKKKEA 271
            :.:::..:.|             ||
Zfish   211 DLIEERSIVF-------------DG---------------------------------------- 222

  Fly   272 LPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAEKLGLKLATRDLRLTDPKLQIKAV 336

Zfish   223 ----------------------------------------------------------------- 222

  Fly   337 LGQWLPIDKSVLHMVIQHVPPP--HKISDERAQRLLYPANVD-------LSSLPPETLELKESFT 392
                 |..:||.:   :.:||.  .:.:|.|.:.:...||.|       |....|..|:||.:..
Zfish   223 -----PFGESVRY---EDIPPEMRSEAADRRQELVECVANADETLGEMFLEERVPTVLDLKAAVR 279

  Fly   393 SCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQSEQAELEKISQ 457
            ......|        .:||.:       ...|.::.||...|.|...:....:....|.|.:  :
Zfish   280 RATVKRS--------FSPVLV-------GSALKNKGVQPLLDAVLEYLPNPTEVQNYAILNE--E 327

  Fly   458 GVEQLSTQVVGPEKEESKP-----EEADQNEFVFIAFARVFSGTLKRGMELFNLSPKHDPRQPTH 517
            |..:.|..::...:::::|     .:.:...|..:.:.||:.|.|::...:      |:.|  |.
Zfish   328 GESEGSKILMDSTRDDTQPFVGLAFKLEAGRFGQLTYVRVYQGCLRKTDYI------HNSR--TG 384

  Fly   518 RKEGEAPYASRVTIGDLYMFMGGELQLLDEVPAGNIVGIGGLE--SHIVKTATLSSSLDCTSFSE 580
            |         ||.:..|......:::.::...||:|..:.|::  |....||..:::|...|..
Zfish   385 R---------RVRVQRLVRLHADQMEDVEVAYAGDICALFGIDCASGDTFTARNNANLSMESIH- 439

  Fly   581 LSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSV-APTGEHVITTLGEVHVEKCVHD 644
               :..|::.:||.|....|..||.||:....:.|...:|.. ..:.|.:|:.:||:|:|.....
Zfish   440 ---VPEPVISMAIRPSNKNDTDKLSKGISRFTREDPTFRVHFDTESKETIISGMGELHLEIYSQR 501

  Fly   645 LEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAVQQTLNKLGTLKVIA 709
            :|:.|:...| :.||.|:||||:..|...:..::.  ::.......|.|.|.:.|:
Zfish   502 MEREYSCPCV-MGKPKVAFRETLTSAVPFEYTHKK--QSGGSGQYGKVIGVLEPLD--------- 554

  Fly   710 VPLPAEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKVKLIAALKDLQLFGLSTLSPEEL 774
                                          ||.:|      ||:.                .:|.
Zfish   555 ------------------------------SENYT------KVEF----------------SDET 567

  Fly   775 VNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKDFNSSLVNGFQITSVAGP 839
            |           ||||                             .|.|..::..||:.....||
Zfish   568 V-----------GTNI-----------------------------PKQFVPAVEKGFRDACEKGP 592

  Fly   840 LCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQV--LTAAKEVCRQAFQNQPQRLVTPMYSCNI 902
            |....:.||.|.:         ||.......|.::  :.|.:...:||.:.....::.|:.|..|
Zfish   593 LIGHKISGVRFVL---------EDGAHHMVDSNEISFIRAGEGAVKQALEKATVVILEPVMSVEI 648

  Fly   903 VVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQEMRKQTSGLACPQLMF 967
            |...|..|.:.|.:.|||| ::||. ....|.|.:...:|:.:.|.:|.|:|..|.|.....:.:
Zfish   649 VAPNEFQGAVIAGVNRRHG-VISGQ-DGADGYFTLYADIPLNDMFGYATELRSCTEGKGEYTMEY 711

  Fly   968 SHWE 971
            |.::
Zfish   712 SRYQ 715

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	197/979 (20%)
		EF2	20..249	CDD:206672	66/233 (28%)
		EF2_II	485..572	CDD:293913	18/88 (20%)
		EF2_snRNP_III	587..658	CDD:293918	20/71 (28%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	40/242 (17%)
		eEF2_snRNP_like_C	896..974	CDD:239763	23/76 (30%)
gfm1	NP_001073463.1	EF-G	43..315	CDD:206673	88/435 (20%)
		PRK12740	47..726	CDD:237186	193/971 (20%)
		mtEFG1_II_like	347..427	CDD:293908	17/96 (18%)
		EFG_III	441..516	CDD:293919	21/75 (28%)
		EFG_mtEFG1_IV	519..635	CDD:238715	36/227 (16%)
		mtEFG1_C	641..718	CDD:239764	23/77 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900