DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33158 and eRF3

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001260415.1	Gene:	eRF3 / 34658	FlyBaseID:	FBgn0020443	Length:	619	Species:	Drosophila melanogaster

Alignment Length:	368	Identity:	73/368 - (19%)
Similarity:	133/368 - (36%)	Gaps:	103/368 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PVVEGSDLVLLQ--RRRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLR--------- 55
            |.|....:|.::  |.:::..|:..:.|||.||:|:...:::..|::.:|...|..
  Fly   176 PKVSKKKVVKVEENRSKREHVNVVFIGHVDAGKSTIGGQIMSLTGMVDKRTLEKYEREAREKSRE 240

  Fly    56 ------YLDNRSDEQERGITMKSSSISLYYQEAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRL 114
                  .||...:|:::|   |:..:...:.|.:...      ..::|:|||..|...:......
  Fly   241 SWYLSWALDTNQEERDKG---KTVEVGRAFFETDRKH------FTILDAPGHKSFVPNMIGGAAQ 296

  Fly   115 CDGAIVVVDVVEGV-------GPQTRACLRQIYEEQLKPVLVL-NKLDRLILEKQMDPL----DA 167
            .|.|::|:...:|.       |.|||..........:|.::|| ||:|        ||.    ..
  Fly   297 ADLAVLVISARKGEFETGFDRGGQTREHAMLAKTAGVKHLVVLVNKMD--------DPTVNWDQT 353

  Fly   168 YFHLCQVLEQVNAVLGSIFASDILAKEDI---TKKDNYESALEEVDDSELYFSPSSG-------- 221
            .::.|                    |:.|   .||..:..|      .:|.|.|.||
  Fly   354 RYNEC--------------------KDKILPYLKKLGFNPA------KDLTFMPCSGLSGYGLKD 392

  Fly   222 --NVIFCSAYDGWAF--SVRDFAAMYAKR-------LEMSRKDLENVLWGDFYYNSKKKEALPGA 275
              ....|..|.|.||  .:.:..::..|.       :....||:..|:.|.....:.:|     .
  Fly   393 QIPETLCPWYRGPAFIPFIDELPSLNRKSDGPFIMPIVDKYKDMGTVVMGKVESGTARK-----G 452

  Fly   276 QEKAKKPMFVQFVLENIWS-LYDIIAI---RKDKDKLPGIAEK 314
            |.....|...|..::.::| .:::.::   ...|.||.||.|:
  Fly   453 QNLLVMPNRTQVAVDQLFSDDFEVTSVGPGENVKIKLKGIEEE 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	69/353 (20%)
		EF2	20..249	CDD:206672	54/277 (19%)
		EF2_II	485..572	CDD:293913
		EF2_snRNP_III	587..658	CDD:293918
		aeEF2_snRNP_like_IV	658..899	CDD:238839
		eEF2_snRNP_like_C	896..974	CDD:239763
eRF3	NP_001260415.1	PAM2	12..28	CDD:284542
		TEF1	191..619	CDD:227581	69/353 (20%)
		EF1_alpha	197..416	CDD:206670	53/261 (20%)
		eRF3_II	424..505	CDD:293906	15/77 (19%)
		eRF3_C_III	511..617	CDD:294003
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464655
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840