DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33158 and eef2l2

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	XP_021332246.1	Gene:	eef2l2 / 336168	ZFINID:	ZDB-GENE-030131-8112	Length:	861	Species:	Danio rerio

Alignment Length:	1041	Identity:	310/1041 - (29%)
Similarity:	479/1041 - (46%)	Gaps:	250/1041 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQERGITMKSSSISLYY 79
            ::..:||:.::|||||||:||.||||...|||:...||:.|:.|.|.|||||.||:||::|||||
Zfish    15 KKSNIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLYY 79

  Fly    80 QEAE-------EMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLR 137
            :.:|       :......:|||||||||||||||||:.|:|:.|||:||||.|.||..||...||
Zfish    80 ELSENDSAFIKQCKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLR 144

  Fly   138 QIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKKDNY 202
            |...|::||||::||:||.:||.|::|.:.:....:::|.||.::.:                 |
Zfish   145 QAIAERIKPVLMMNKMDRALLELQLEPDELFQTFQRIVENVNVIIST-----------------Y 192

  Fly   203 ESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMY--------------------AKRL 247
            ... |......:...|..|.|.|.|...||||:::.||.||                    ||::
Zfish   193 GEG-EHGPMGNIMVDPVIGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGDKKKGDLPPAERAKKV 256

  Fly   248 -EMSRKDLENVLWGDFYYN---SKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKL 308
             ||.:|     ||||.|::   .|..:....|..|.....|.|.||:.|:.::|.|...| |::.
Zfish   257 EEMMKK-----LWGDKYFDPSCGKFSKTANNADGKKLPRTFCQLVLDPIFKVFDAIMNFK-KEET 315

  Fly   309 PGIAEKLGLKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPA 373
            ..:.|||.:||...| :..:.|..:|||:.:|||...::|.|:..|:|.|......|.: |||..
Zfish   316 QKLIEKLEVKLDAED-KEKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQRYRCE-LLYEG 378

  Fly   374 NVDLSSLPPETLELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRR 438
                    |...|......:||..:. ::.::|||.|.                     .|:.|
Zfish   379 --------PGDDEAAMGIKNCDPKAP-LMMYISKMVPT---------------------TDKGR- 412

  Fly   439 RIEERKQQSEQAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMEL 503
                                                           |.||.|||||.:..|.::
Zfish   413 -----------------------------------------------FYAFGRVFSGIVSTGQKV 430

  Fly   504 FNLSPKHDPRQPTHRKEGEAPYASRVTIGDLY--------MFMGGELQLLDEVPAGNIVGIGGLE 560
            ..:.|...|    .:||            |||        :.||..::.:::||.|||||:.|::
Zfish   431 RIMGPNFTP----GKKE------------DLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVD 479

  Fly   561 SHIVKTATLSSSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPT 625
            ..:|||.|:::..:..:...:....:|::|||:|...|.|:||||:|||.|.::|..||..:..:
Zfish   480 QFLVKTGTITTFENSHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEES 544

  Fly   626 GEHVITTLGEVHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVS 690
            |||::...||:|:|.|:.|||:.:|.|.:..|.|:||:|||:                   .|.|
Zfish   545 GEHIVAGAGELHLEICLKDLEEDHACIPLKKSDPVVSYRETV-------------------SDES 590

  Fly   691 KKIAVQQTLNKLGTLKVIAVPLP---AEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKV 752
            .::.:.::.||...|.:.:.|.|   ||.::..:..|.  :||..  |.:.|:||:...:|..:
Zfish   591 DQVCLSKSPNKHNRLYMKSRPFPDGLAEDIDKGDVSSR--QELKL--RARYLAEKYEWEVAEAR- 650

  Fly   753 KLIAALKDLQLFGLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKT 817
                                    :||..||...|.|||:                   ||....
Zfish   651 ------------------------KIWCFGPDGTGPNILV-------------------DITKGV 672

  Fly   818 DPRKDFNSSLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVC 882
            ....:...|:|.|||..:..|.||||.|:.|.|.:.:.::.:   |...||  .||::..|:.|.
Zfish   673 QYLNEIKDSVVAGFQWATKEGALCEENMRAVRFDIHDVTLHA---DAIHRG--GGQIIPTARRVL 732

  Fly   883 RQAFQNQPQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESF 947
            ..:......||:.|:|...|....:::|.:|.|:.|:.|.:.......|:..|.|...|||.|||
Zfish   733 YASVLTAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPIFVVKAYLPVNESF 797

  Fly   948 NFAQEMRKQTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKG 1012
            .|..::|..|.|.|.||.:|.||:::..||:.:.:...:::     ||:           |:|||
Zfish   798 GFTADLRSNTGGQAFPQCVFDHWQILPGDPYDVNSKPSQIV-----ADT-----------RKRKG 846

  Fly  1013 L 1013
            |
Zfish   847 L 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	310/1041 (30%)
		EF2	20..249	CDD:206672	105/256 (41%)
		EF2_II	485..572	CDD:293913	30/94 (32%)
		EF2_snRNP_III	587..658	CDD:293918	31/70 (44%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	56/243 (23%)
		eEF2_snRNP_like_C	896..974	CDD:239763	27/77 (35%)
eef2l2	XP_021332246.1	PTZ00416	1..861	CDD:240409	310/1041 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820