Protein Alignment CG33158 and EEF2

DIOPT Version :9

• Sequence 1: NP_788515.1
• Gene: CG33158 / 39834
• FlyBaseID: FBgn0053158
• Length: 1033
• Species: Drosophila melanogaster
• Sequence 2: NP_001952.1
• Gene: EEF2 / 1938
• HGNCID: 3214
• Length: 858
• Species: Homo sapiens
• Alignment Length: 1036
• Identity: 314/1036 - (30%)
• Similarity: 485/1036 - (46%)
• Gaps: 243/1036 - (23%)

  Fly    15 RRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQERGITMKSSSISLYY 79
            ::..:||:.::|||||||:||.||||...|||:...||:.|:.|.|.|||||.||:||::|||:|
Human    15 KKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFY 79

  Fly    80 Q----------EAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRA 134
            :          ::::.||   :|||||||||||||||||:.|:|:.|||:||||.|.||..||..
Human    80 ELSENDLNFIKQSKDGAG---FLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTET 141

  Fly   135 CLRQIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKK 199
            .|||...|::||||::||:||.:||.|::|.:.|....:::|.||.::.:
Human   142 VLRQAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIIST--------------- 191

  Fly   200 DNYESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRL-----------EMSRK- 252
              |... |......:...|..|.|.|.|...||||:::.||.||..:.           |.::|
Human   192 --YGEG-ESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLGPAERAKKV 253

  Fly   253 -DLENVLWGDFYY---NSKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAE 313
             |:...||||.|:   |.|..::....:.|.....|.|.:|:.|:.::|.|...| |::...:.|
Human   254 EDMMKKLWGDRYFDPANGKFSKSATSPEGKKLPRTFCQLILDPIFKVFDAIMNFK-KEETAKLIE 317

  Fly   314 KLGLKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLS 378
            ||.:||.:.| :..:.|..:|||:.:|||...::|.|:..|:|.|......|.: |||..
Human   318 KLDIKLDSED-KDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCE-LLYEG----- 375

  Fly   379 SLPPETLELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEER 443
              ||:. |......|||.... ::.::|||.|.
Human   376 --PPDD-EAAMGIKSCDPKGP-LMMYISKMVPT-------------------------------- 404

  Fly   444 KQQSEQAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMELFNLSP 508
                                               :|:..  |.||.|||||.:..|:::..:.|
Human   405 -----------------------------------SDKGR--FYAFGRVFSGLVSTGLKVRIMGP 432

  Fly   509 KHDPRQPTHRKEGEAPYASRVTIGDLY--------MFMGGELQLLDEVPAGNIVGIGGLESHIVK 565
            .:.|    .:||            |||        :.||..::.:::||.|||||:.|::..:||
Human   433 NYTP----GKKE------------DLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVK 481

  Fly   566 TATLSSSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPTGEHVI 630
            |.|:::.....:...:....:|::|||:|...|.|:||||:|||.|.::|..||..:..:|||:|
Human   482 TGTITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHII 546

  Fly   631 TTLGEVHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAV 695
            ...||:|:|.|:.|||:.:|.|.:..|.|:||:|||:                :|:.:|   :.:
Human   547 AGAGELHLEICLKDLEEDHACIPIKKSDPVVSYRETV----------------SEESNV---LCL 592

  Fly   696 QQTLNKLGTLKVIAVPLP---AEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKVKLIAA 757
            .::.||...|.:.|.|.|   ||.::..|..:.  :||.  .|.:.|:||:...:|..:
Human   593 SKSPNKHNRLYMKARPFPDGLAEDIDKGEVSAR--QELK--QRARYLAEKYEWDVAEAR------ 647

  Fly   758 LKDLQLFGLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKD 822
                               :||..||...|.|||                   |||........:
Human   648 -------------------KIWCFGPDGTGPNIL-------------------TDITKGVQYLNE 674

  Fly   823 FNSSLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVCRQAFQ 887
            ...|:|.|||..:..|.||||.|:||.|.|.:.::.:   |...||  .||::..|:.....:..
Human   675 IKDSVVAGFQWATKEGALCEENMRGVRFDVHDVTLHA---DAIHRG--GGQIIPTARRCLYASVL 734

  Fly   888 NQPQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQE 952
            ....||:.|:|...|....:::|.:|.|:.|:.|.:.......|:..|.|...|||.|||.|..:
Human   735 TAQPRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTAD 799

  Fly   953 MRKQTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKGL 1013
            :|..|.|.|.||.:|.||:::..|||                |:::|....:...|:||||
Human   800 LRSNTGGQAFPQCVFDHWQILPGDPF----------------DNSSRPSQVVAETRKRKGL 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	314/1036 (30%)
		EF2	20..249	CDD:206672	104/249 (42%)
		EF2_II	485..572	CDD:293913	30/94 (32%)
		EF2_snRNP_III	587..658	CDD:293918	32/70 (46%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	59/243 (24%)
		eEF2_snRNP_like_C	896..974	CDD:239763	27/77 (35%)
EEF2	NP_001952.1	PTZ00416	1..858	CDD:240409	314/1036 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820