DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33158 and Eef2

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_031933.1	Gene:	Eef2 / 13629	MGIID:	95288	Length:	858	Species:	Mus musculus

Alignment Length:	1033	Identity:	313/1033 - (30%)
Similarity:	482/1033 - (46%)	Gaps:	237/1033 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 RRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQERGITMKSSSISLYY 79
            ::..:||:.::|||||||:||.||||...|||:...||:.|:.|.|.|||||.||:||::|||:|
Mouse    15 KKANIRNMSVIAHVDHGKSTLTDSLVCKAGIIASARAGETRFTDTRKDEQERCITIKSTAISLFY 79

  Fly    80 QEAE-------EMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQTRACLR 137
            :.:|       :......:|||||||||||||||||:.|:|:.|||:||||.|.||..||...||
Mouse    80 ELSENDLNFIKQSKDGSGFLINLIDSPGHVDFSSEVTAALRVTDGALVVVDCVSGVCVQTETVLR 144

  Fly   138 QIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDITKKDNY 202
            |...|::||||::||:||.:||.|::|.:.|....:::|.||.::.:                 |
Mouse   145 QAIAERIKPVLMMNKMDRALLELQLEPEELYQTFQRIVENVNVIIST-----------------Y 192

  Fly   203 ESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAKRL-----------EMSRK--DL 254
            ... |......:...|..|.|.|.|...||||:::.||.||..:.           |.::|  |:
Mouse   193 GEG-ESGPMGNIMIDPVLGTVGFGSGLHGWAFTLKQFAEMYVAKFAAKGEGQLSAAERAKKVEDM 256

  Fly   255 ENVLWGDFYY---NSKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPGIAEKLG 316
            ...||||.|:   |.|..::......|.....|.|.:|:.|:.::|.| :...|::...:.|||.
Mouse   257 MKKLWGDRYFDPANGKFSKSANSPDGKKLPRTFCQLILDPIFKVFDAI-MNFRKEETAKLIEKLD 320

  Fly   317 LKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANVDLSSLP 381
            :||.:.| :..:.|..:|||:.:|||...::|.|:..|:|.|......|.: |||..       |
Mouse   321 IKLDSED-KDKEGKPLLKAVMRRWLPAGDALLQMITIHLPSPVTAQKYRCE-LLYEG-------P 376

  Fly   382 PETLELKESFTSCDANSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRRIEERKQQ 446
            |:. |......|||.... ::.::|||.|.
Mouse   377 PDD-EAAMGIKSCDPKGP-LMMYISKMVPT----------------------------------- 404

  Fly   447 SEQAELEKISQGVEQLSTQVVGPEKEESKPEEADQNEFVFIAFARVFSGTLKRGMELFNLSPKHD 511
                                            :|:..  |.||.|||||.:..|:::..:.|.:.
Mouse   405 --------------------------------SDKGR--FYAFGRVFSGVVSTGLKVRIMGPNYT 435

  Fly   512 PRQPTHRKEGEAPYASRVTIGDLY--------MFMGGELQLLDEVPAGNIVGIGGLESHIVKTAT 568
            |    .:||            |||        :.||..::.:::||.|||||:.|::..:|||.|
Mouse   436 P----GKKE------------DLYLKPIQRTILMMGRYVEPIEDVPCGNIVGLVGVDQFLVKTGT 484

  Fly   569 LSSSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKGLKLLNQADACVQVSVAPTGEHVITTL 633
            :::.....:...:....:|::|||:|...|.|:||||:|||.|.::|..||..:..:|||:|...
Mouse   485 ITTFEHAHNMRVMKFSVSPVVRVAVEAKNPADLPKLVEGLKRLAKSDPMVQCIIEESGEHIIAGA 549

  Fly   634 GEVHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAATVDMVNEAIVKTAEDKDVSKKIAVQQT 698
            ||:|:|.|:.|||:.:|.|.:..|.|:||:|||:                :|:.:|   :.:.::
Mouse   550 GELHLEICLKDLEEDHACIPIKKSDPVVSYRETV----------------SEESNV---LCLSKS 595

  Fly   699 LNKLGTLKVIAVPLP---AEAVELLETHSEFFKELAAIPRNQLLSEKWTALLASIKVKLIAALKD 760
            .||...|.:.|.|.|   ||.::..|..:.  :||.|  |.:.|:||:...:|..:
Mouse   596 PNKHNRLYMKARPFPDGLAEDIDKGEVSAR--QELKA--RARYLAEKYEWDVAEAR--------- 647

  Fly   761 LQLFGLSTLSPEELVNRIWALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKDFNS 825
                            :||..||...|.|||                   |||........:...
Mouse   648 ----------------KIWCFGPDGTGPNIL-------------------TDITKGVQYLNEIKD 677

  Fly   826 SLVNGFQITSVAGPLCEEPMQGVCFAVLEWSIQSEGEDLNSRGPFSGQVLTAAKEVCRQAFQNQP 890
            |:|.|||..:..|.||||.|:||.|.|.:.::.:   |...||  .||::..|:.....:.....
Mouse   678 SVVAGFQWATKEGALCEENMRGVRFDVHDVTLHA---DAIHRG--GGQIIPTARRCLYASVLTAQ 737

  Fly   891 QRLVTPMYSCNIVVNAEMLGKMYAVIGRRHGKILSGDLTQGSGNFAVTCLLPVIESFNFAQEMRK 955
            .||:.|:|...|....:::|.:|.|:.|:.|.:.......|:..|.|...|||.|||.|..::|.
Mouse   738 PRLMEPIYLVEIQCPEQVVGGIYGVLNRKRGHVFEESQVAGTPMFVVKAYLPVNESFGFTADLRS 802

  Fly   956 QTSGLACPQLMFSHWEVIDIDPFWLPTTEEELMHFGEKADSANRAKVYMDSVRRRKGL 1013
            .|.|.|.||.:|.||:::..|||                |:::|....:...|:||||
Mouse   803 NTGGQAFPQCVFDHWQILPGDPF----------------DNSSRPSQVVAETRKRKGL 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	313/1033 (30%)
		EF2	20..249	CDD:206672	103/246 (42%)
		EF2_II	485..572	CDD:293913	30/94 (32%)
		EF2_snRNP_III	587..658	CDD:293918	32/70 (46%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	60/243 (25%)
		eEF2_snRNP_like_C	896..974	CDD:239763	27/77 (35%)
Eef2	NP_031933.1	PTZ00416	1..858	CDD:240409	313/1033 (30%)
		EF2	20..233	CDD:206672	102/230 (44%)
		EF2_snRNP_like_II	394..488	CDD:293901	35/178 (20%)
		EF2_snRNP_III	503..574	CDD:293918	32/70 (46%)
		aeEF2_snRNP_like_IV	574..746	CDD:238839	60/243 (25%)
		eEF2_snRNP_like_C	742..821	CDD:239763	27/78 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D140796at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820