DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG33158 and Efl1

DIOPT Version :9

Sequence 1:	NP_788515.1	Gene:	CG33158 / 39834	FlyBaseID:	FBgn0053158	Length:	1033	Species:	Drosophila melanogaster
Sequence 2:	NP_001153144.1	Gene:	Efl1 / 101592	MGIID:	2141969	Length:	1127	Species:	Mus musculus

Alignment Length:	1152	Identity:	519/1152 - (45%)
Similarity:	722/1152 - (62%)	Gaps:	147/1152 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VVEGSD-LVLLQRRRQQVRNICILAHVDHGKTTLADSLVASNGIISQRMAGKLRYLDNRSDEQER 66
            |:.|.| ::.||:....:||||:|||||||||||||.|::||||||.|:||||||:|:|.|||.|
Mouse     2 VLSGVDKMIRLQKNTANIRNICVLAHVDHGKTTLADCLISSNGIISSRLAGKLRYMDSREDEQVR 66

  Fly    67 GITMKSSSISLYYQEAEEMAGNPDYLINLIDSPGHVDFSSEVSTAVRLCDGAIVVVDVVEGVGPQ 131
            |||||||:|||:|.|     |:.:|||||||||||||||||||||||:|||.|:|||.||||.||
Mouse    67 GITMKSSAISLHYAE-----GHEEYLINLIDSPGHVDFSSEVSTAVRICDGCIIVVDAVEGVCPQ 126

  Fly   132 TRACLRQIYEEQLKPVLVLNKLDRLILEKQMDPLDAYFHLCQVLEQVNAVLGSIFASDILAKEDI 196
            |:|.|||.:.|.::||||:||:||||:|.:..|.:||.||..:|||:||:.|::|.|.:|  |:.
Mouse   127 TQAVLRQAWLENIRPVLVINKIDRLIVELKFTPQEAYSHLKNILEQINALTGTLFTSKVL--EER 189

  Fly   197 TKKD----------------NYESALEEVDDSELYFSPSSGNVIFCSAYDGWAFSVRDFAAMYAK 245
            .:::                ::.:.||:||||:|||||..|||:|.||.|||.|.:..||.:|::
Mouse   190 AERETESQAKPHSEQGEQVYDWSAGLEDVDDSQLYFSPEQGNVVFTSAIDGWGFGIEHFARIYSQ 254

  Fly   246 RLEMSRKDLENVLWGDFYYNSKKKEALPGAQEKAKKPMFVQFVLENIWSLYDIIAIRKDKDKLPG 310
            ::.:.::.|...||||:|.|.|.|:.:...|.|.|||:|||.:|||||||||.: ::|||:|:..
Mouse   255 KIGIKKEVLLKTLWGDYYINMKAKKIMKVDQAKGKKPLFVQLILENIWSLYDAV-LKKDKEKIDK 318

  Fly   311 IAEKLGLKLATRDLRLTDPKLQIKAVLGQWLPIDKSVLHMVIQHVPPPHKISDERAQRLLYPANV 375
            |...||||:..|:.|.:|||:||.|:..|||||..:||.||...:|.|..::.||.::||...:.
Mouse   319 IVTSLGLKIGAREARHSDPKVQINAICSQWLPISHAVLAMVCHKLPSPLDMTSERVEKLLCTGSQ 383

  Fly   376 DLSSLPPETLELKESFTSCDA-NSSNVIAFVSKMTPVHITHLPQNRPKRLTDQEVQQRRDEVRRR 439
            ...||||||..||.:|..|.: :::.||.|||||..|.:..||||:|:.||.:|:.|||:..|:|
Mouse   384 TFESLPPETQALKAAFMKCGSEDTAPVIIFVSKMFAVDVKALPQNKPRPLTQEEMAQRRERARQR 448

  Fly   440 IEERKQQSEQAELEKISQGVEQ----LSTQVVGPEKEESKPEEAD-------------QNEFVFI 487
            ..|:...::    .:.|||..|    |.|   .|.::|.:.:|.|             .::..||
Mouse   449 HAEKLAAAQ----GQTSQGPTQDGGALET---SPHEDEPRGDEPDVASVSRQPVSQEESSQEAFI 506

  Fly   488 AFARVFSGTLKRGMELFNLSPKHDPRQPTHRKE----------GEAPYASRVTIGDLYMFMGGEL 542
            ||||||||..:||.::|.|.||:.|.....|..          ...|:.:..|:.:||:.||.||
Mouse   507 AFARVFSGIARRGKKIFVLGPKYSPVDFLQRVPLGFSAPLEDLPPVPHMACCTLENLYLLMGREL 571

  Fly   543 QLLDEVPAGNIVGIGGLESHIVKTATLSSSLDCTSFSELSVMATPILRVAIEPVQPQDMPKLVKG 607
            :.|:|||.||::|||||:..::|:|||.|...|..|..|:..||||:|||:||..|.:||:||||
Mouse   572 EDLEEVPPGNVLGIGGLQDFVLKSATLCSLPSCPPFIPLNFEATPIVRVAVEPKHPSEMPQLVKG 636

  Fly   608 LKLLNQADACVQVSVAPTGEHVITTLGEVHVEKCVHDLEQSYAKIKVNVSKPIVSFRETIVPAAT 672
            :|||||||.||||.:..|||||:.|.||||:::|:.||.:.:|||.::||:||:.|||||.....
Mouse   637 MKLLNQADPCVQVLIQETGEHVLVTAGEVHLQRCLDDLRERFAKIHISVSEPIIPFRETITKPPK 701

  Fly   673 VDMVNEAI---VKTA-------EDKDVSKKIAVQQ-------TLNKLGTLKVIAVPLPAEAVELL 720
            ||||||.|   .|.|       |...:.:.|.|..       |.|||.||.|.|:|||.|...:|
Mouse   702 VDMVNEEIGRQQKVAVIHQTKEEQSKIPEGIHVDSDGLITIPTPNKLATLSVRAIPLPEEVTRIL 766

  Fly   721 ETHSEFFKELAAIP------RN-QLLSEKWTALLASIKVKLIAALKDLQLFGLSTLSPEELVNRI 778
            |.:|:..:.:..:.      || |.:.:|....:...|.||     :..|.|...   ...|::|
Mouse   767 EENSDLIRSMELLTSSLNEGRNTQAIHQKTQEKIWEFKGKL-----EKHLTGRKW---RNTVDQI 823

  Fly   779 WALGPRNCGTNILLNLSDYEQPDFWSSHAKSDTDIRSKTDPRKDFNSSLVNGFQITSVAGPLCEE 843
            |:.|||.||.|||::.|:..|...||..|..::...|:.   :||.:|:|:|||:.:::||:|||
Mouse   824 WSFGPRKCGPNILVSRSEDFQNSVWSGPAGRESKEASRF---RDFGNSIVSGFQLATLSGPMCEE 885

  Fly   844 PMQGVCFAVLEWSI-----------QSEGE-----------------DLNSR------------- 867
            |:.||||.:.:|.:           |.:|:                 |.|..
Mouse   886 PLMGVCFVLEKWELNKCAEQGASDKQHQGQCDLAGEGQGGGKTCHVGDENQEQQDVCSEPFEETS 950

  Fly   868 -----------GPFSGQVLTAAKEVCRQAFQNQPQRLVTPMYSCNIVVNAEMLGKMYAVIGRRHG 921
                       ||||||::...||.||.|.|.:||||:..||:|:|:..:::||::|||:.:|.|
Mouse   951 QKGDSPVIDCYGPFSGQLIATMKEACRYALQVKPQRLMAAMYTCDIMATSDVLGRVYAVLSKREG 1015

  Fly   922 KILSGDLTQGSGNFAVTCLLPVIESFNFAQEMRKQTSGLACPQLMFSHWEVIDIDPFWLPTTEEE 986
            ::|..::.:|:..|.:..:|||.|||.||.|:||:|||||.|||:|||||||..||||:||||||
Mouse  1016 RVLQEEMKEGTDMFIIKAVLPVAESFGFADEIRKRTSGLASPQLVFSHWEVIPSDPFWVPTTEEE 1080

  Fly   987 LMHFGEKADSANRAKVYMDSVRRRKGLFVDEQVVEHAEKQRTLSKNK 1033
            .:||||||||.|:|:.||::||:||||:|:|::||||||||||||||
Mouse  1081 YLHFGEKADSENQARKYMNAVRKRKGLYVEEKIVEHAEKQRTLSKNK 1127

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33158	NP_788515.1	PTZ00416	15..1016	CDD:240409	498/1120 (44%)
		EF2	20..249	CDD:206672	142/244 (58%)
		EF2_II	485..572	CDD:293913	41/96 (43%)
		EF2_snRNP_III	587..658	CDD:293918	42/70 (60%)
		aeEF2_snRNP_like_IV	658..899	CDD:238839	99/316 (31%)
		eEF2_snRNP_like_C	896..974	CDD:239763	39/77 (51%)
Efl1	NP_001153144.1	PTZ00416	1..1110	CDD:240409	503/1133 (44%)
		EF2	20..253	CDD:206672	141/239 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	429..496		20/73 (27%)
		EF2_II	505..600	CDD:293913	41/94 (44%)
		EF2_snRNP_III	616..687	CDD:293918	42/70 (60%)
		aeEF2_snRNP_like_IV	687..993	CDD:238839	99/316 (31%)
		eEF2_snRNP_like_C	990..1068	CDD:239763	39/77 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837947
Domainoid	1	1.000	287	1.000	Domainoid score	I1589
eggNOG	1	0.900	-	-		E1_COG0480
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11599
Inparanoid	1	1.050	926	1.000	Inparanoid score	I352
Isobase	1	0.950	-	0	Normalized mean entropy	S2283
OMA	1	1.010	-	-		QHG53952
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004608
OrthoInspector	1	1.000	-	-		oto93874
orthoMCL	1	0.900	-	-		OOG6_102502
Panther	1	1.100	-	-	LDO	PTHR42908
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2256
SonicParanoid	1	1.000	-	-		X3227
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740