DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment TyrRS and MARS2

DIOPT Version :9

Sequence 1:NP_648895.1 Gene:TyrRS / 39829 FlyBaseID:FBgn0027080 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_612404.1 Gene:MARS2 / 92935 HGNCID:25133 Length:593 Species:Homo sapiens


Alignment Length:380 Identity:73/380 - (19%)
Similarity:128/380 - (33%) Gaps:110/380 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 ITPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEV 68
            |||.....::.:.|.|.|.|..:::    |...::||....|......:|.:..:.::|      
Human   233 ITPEPFHHVVLQWLDEELPDLSVSR----RSSHLHWGIPVPGDDSQTIYVWLDALVNYL------ 287

  Fly    69 TILFADLHAYLD-NMKAPW---------SLLELRTKYYEQVIKAMLSSIGV-PLEKLKF-----V 117
            |::     .|.: ..|:.|         .:|:....|:    .|.|...|: |.:::..     |
Human   288 TVI-----GYPNAEFKSWWPATSHIIGKDILKFHAIYW----PAFLLGAGMSPPQRICVHSHWTV 343

  Fly   118 KGSDYQLSK-------------EYTLDVYK---LSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYP 166
            .|.  ::||             .||:|.::   |...|...|......:|||.:...|...|   
Human   344 CGQ--KMSKSLGNVVDPRTCLNRYTVDGFRYFLLRQGVPNWDCDYYDEKVVKLLNSELADAL--- 403

  Fly   167 GLQALDEEYLKVDAQFGGVDQRKIFTFSEKYLPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKI 231
                            ||:..|   ..:::..|...|........|..|||.|..:.:..||  .
Human   404 ----------------GGLLNR---CTAKRINPSETYPAFCTTCFPSEPGLVGPSVRAQAED--Y 447

  Fly   232 DLLDSPANVKKKLKKAFCEPGNIADNGLLSFVKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYED 296
            .|:.:.|.:.|::...:       ||..:......:.|..::..|| |.|.|...     |.:|.
Human   448 ALVSAVATLPKQVADHY-------DNFRIYKALEAVSSCVRQTNGF-VQRHAPWK-----LNWES 499

  Fly   297 LEKYYAEDKLHPGD-------LKATVE--KYINRLLDPIRKAFENPELQKLSAAA 342
                       |.|       |...:|  :....||.|:..:..:..|.:|..:|
Human   500 -----------PVDAPWLGTVLHVALECLRVFGTLLQPVTPSLADKLLSRLGVSA 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRSNP_648895.1 nt_trans 8..334 CDD:294020 67/366 (18%)
tyrS 12..332 CDD:272976 67/360 (19%)
tRNA_bind_EMAP-II_like 364..466 CDD:239198
MARS2NP_612404.1 PRK11893 46..581 CDD:237012 73/380 (19%)
'HIGH' region 52..62
'KMSKS' region 347..351 1/3 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0143
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.