DRSC/TRiP Functional Genomics Resources

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Protein Alignment TyrRS and AIMP1

DIOPT Version :10

Sequence 1:NP_648895.1 Gene:TyrRS / 39829 FlyBaseID:FBgn0027080 Length:525 Species:Drosophila melanogaster
Sequence 2:NP_004748.2 Gene:AIMP1 / 9255 HGNCID:10648 Length:312 Species:Homo sapiens


Alignment Length:375 Identity:112/375 - (29%)
Similarity:180/375 - (48%) Gaps:77/375 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 LLSGLLYPGLQALDE--EYLKVDAQFGGVDQRKIFTFSEKYLPQ--LGYEKRIHFMNPMVPGLAG 219
            :|..|...|.:| |:  ||||          :::....||.:.|  |..||::...|        
Human     7 VLKRLEQKGAEA-DQIIEYLK----------QQVSLLKEKAILQATLREEKKLRVEN-------- 52

  Fly   220 GKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGN-IADNGLLS--FVKHVLFSLFKEGEGFEVNR 281
            .|:....|:.|.:|:.  |.::..:|:.....|. :..|.::|  .::....:....|     .:
Human    53 AKLKKEIEELKQELIQ--AEIQNGVKQIPFPSGTPLHANSMVSENVIQSTAVTTVSSG-----TK 110

  Fly   282 EAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYINRLLDPIRKAFENPELQKLSAAAYPPP 346
            |...||                    .||.|...||        |.|..|..|.::.|.      
Human   111 EQIKGG--------------------TGDEKKAKEK--------IEKKGEKKEKKQQSI------ 141

  Fly   347 AKVKAGAAPAAGADEDAPHRLDIRVGKVVEVARHPDADTLYVLKIDLAEAQPRTIISGLVKFVTE 411
                ||:|.:...|..   |||:|:|.::...:|||||:|||.::|:.|..|||::||||..|..
Human   142 ----AGSADSKPIDVS---RLDLRIGCIITARKHPDADSLYVEEVDVGEIAPRTVVSGLVNHVPL 199

  Fly   412 EELNQRLVAVLCNLKPSKMRGILSEGMVLCTSNADHTVVEPIVLPATATAGSRLSFEGFSGTPDE 476
            |::..|:|.:||||||:||||:||:.||:|.|:.:.  :|.:..|..:..|.|::|:.|.|.||:
Human   200 EQMQNRMVILLCNLKPAKMRGVLSQAMVMCASSPEK--IEILAPPNGSVPGDRITFDAFPGEPDK 262

  Fly   477 QLNPKKKVWEKLSADFKTNSDGLAVWKD-NFLLTPEGEKLSSKLANCSIK 525
            :||||||:||::..|..||.:.:|.:|. .|.:..:|...:..::|..||
Human   263 ELNPKKKIWEQIQPDLHTNDECVATYKGVPFEVKGKGVCRAQTMSNSGIK 312

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TyrRSNP_648895.1 nt_trans 8..334 CDD:469580 37/181 (20%)
PLN02610 <366..525 CDD:215329 67/159 (42%)
AIMP1NP_004748.2 PRK05431 3..>79 CDD:235461 22/92 (24%)
Required for fibroblast proliferation 6..46 13/49 (27%)
Interaction with HSP90B1. /evidence=ECO:0000250 54..194 47/187 (25%)
Required for endothelial cell death 101..114 2/17 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 107..147 17/82 (21%)
Required for endothelial cell migration 114..192 34/118 (29%)
PLN02610 <140..312 CDD:215329 72/186 (39%)

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