Protein Alignment TyrRS and YARS1

DIOPT Version :10

• Sequence 1: NP_648895.1
• Gene: TyrRS / 39829
• FlyBaseID: FBgn0027080
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_003671.1
• Gene: YARS1 / 8565
• HGNCID: 12840
• Length: 528
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 356/527 - (67%)
• Similarity: 420/527 - (79%)
• Gaps: 18/527 - (3%)

  Fly     5 TPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVT 69
            :|.||..||||||||.||::||.:||.||:|||||||||||||||||||||||||||||||||||
Human     6 SPEEKLHLITRNLQEVLGEEKLKEILKERELKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVT 70

  Fly    70 ILFADLHAYLDNMKAPWSLLELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLDVYK 134
            |||||||||||||||||.|||||..|||.||||||.|||||||||||:||:|||||||||||||:
Human    71 ILFADLHAYLDNMKAPWELLELRVSYYENVIKAMLESIGVPLEKLKFIKGTDYQLSKEYTLDVYR 135

  Fly   135 LSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFSEKYLP 199
            |||||||||:||||||||||||:|||||||||||||||||||||||||||:||||||||:|||||
Human   136 LSSVVTQHDSKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLP 200

  Fly   200 QLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGNIADNGLLSFVK 264
            .|||.||:|.||||||||.|.|||||||:|||||||...:||||||||||||||:.:||:|||:|
Human   201 ALGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFIK 265

  Fly   265 HVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYINRLLDPIRKA 329
            ||||.|..|   |.:.|:.:.||:.|:..|.||||.:|.:.:||||||.:||..:|:||||||:.
Human   266 HVLFPLKSE---FVILRDEKWGGNKTYTAYVDLEKDFAAEVVHPGDLKNSVEVALNKLLDPIREK 327

  Fly   330 FENPELQKLSAAAYPPPAKVK---AGAAPAAGADEDAPHRLDIRVGKVVEVARHPDADTLYVLKI 391
            |..|.|:||::||||.|:|.|   .|.|..:..:|..|.||||||||::.|.:|||||:|||.||
Human   328 FNTPALKKLASAAYPDPSKQKPMAKGPAKNSEPEEVIPSRLDIRVGKIITVEKHPDADSLYVEKI 392

  Fly   392 DLAEAQPRTIISGLVKFVTEEELNQRLVAVLCNLKPSKMRGILSEGMVLCTS-NADHTVVEPIVL 455
            |:.||:|||::||||:||.:|||..|||.|||||||.||||:.|:||:||.| ...:..|||:..
Human   393 DVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVESQGMLLCASIEGINRQVEPLDP 457

  Fly   456 PATATAGSRLSFEGF-SGTPDEQLNPKKKVWEKLSADFKTNSDGLAVWKD-NFLLTPEGEKLSSK 518
            ||.:..|..:..:|: .|.|||:|.|||||:|||.||||.:.:.:|.||. ||:         :|
Human   458 PAGSAPGEHVFVKGYEKGQPDEELKPKKKVFEKLQADFKISEECIAQWKQTNFM---------TK 513

  Fly   519 LANCSIK 525
            |.:.|.|
Human   514 LGSISCK 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:469580	253/325 (78%)
		PLN02610	<366..525	CDD:215329	86/161 (53%)
YARS1	NP_003671.1	nt_trans	8..328	CDD:469580	252/322 (78%)
		'HIGH' region. /evidence=ECO:0000269|PubMed:14671330	44..52		7/7 (100%)
		'KMSKS' region. /evidence=ECO:0000269|PubMed:14671330	222..226		3/3 (100%)
		Nuclear localization signal. /evidence=ECO:0000269|PubMed:22291016	242..247		4/4 (100%)
		PLN02610	<327..528	CDD:215329	103/203 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	339..363		9/23 (39%)