DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS and TYS1

DIOPT Version :9

Sequence 1:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_011701.3	Gene:	TYS1 / 853097	SGDID:	S000003417	Length:	394	Species:	Saccharomyces cerevisiae

Alignment Length:	363	Identity:	205/363 - (56%)
Similarity:	264/363 - (72%)	Gaps:	11/363 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITPAEKKALITRNLQETLGDDKLTKIL--AERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGC 66
            :.|.|...|||:||||.|....:..:|  .:|.||:|||||.||:||..|||||:|:||||||||
Yeast     7 VDPNEAFGLITKNLQEVLNPQIIKDVLEVQKRHLKLYWGTAPTGRPHCGYFVPMTKLADFLKAGC 71

  Fly    67 EVTILFADLHAYLDNMKAPWSLLELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLD 131
            |||:|.|||||:|||||||..::..|.||||..|||:|.||.||:||||||.||.|||:.:||:|
Yeast    72 EVTVLLADLHAFLDNMKAPLEVVNYRAKYYELTIKAILRSINVPIEKLKFVVGSSYQLTPDYTMD 136

  Fly   132 VYKLSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFSEK 196
            :::||::|:|:|||:|||:|||||..||||||:||.:|||||::|.||.|||||||||||..:|:
Yeast   137 IFRLSNIVSQNDAKRAGADVVKQVANPLLSGLIYPLMQALDEQFLDVDCQFGGVDQRKIFVLAEE 201

  Fly   197 YLPQLGYEKRIHFMNPMVPGLA-GGKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGNIADNGLL 260
            .||.|||:||.|.||||||||| |||||:|:.:||||||:.|..||||:..|||.|||:.:||||
Yeast   202 NLPSLGYKKRAHLMNPMVPGLAQGGKMSASDPNSKIDLLEEPKQVKKKINSAFCSPGNVEENGLL 266

  Fly   261 SFVKHVLFSL--FKEGEG---FEVNREAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYIN 320
            |||::|:..:  .|.|..   |.::|..:.||.:|:..:|:::..:.|:||.|.|||..|...||
Yeast   267 SFVQYVIAPIQELKFGTNHFEFFIDRPEKFGGPITYKSFEEMKLAFKEEKLSPPDLKIGVADAIN 331

  Fly   321 RLLDPIRKAF-ENPELQKLSAAAYP--PPAKVKAGAAP 355
            .||:|||:.| .|.|.|:.|...||  .|.|.|....|
Yeast   332 ELLEPIRQEFANNKEFQEASEKGYPVATPQKSKKAKKP 369

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	195/334 (58%)
		tyrS	12..332	CDD:272976	193/328 (59%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198
TYS1	NP_011701.3	tyrS	9..344	CDD:272976	195/334 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	366	1.000	Domainoid score	I123
eggNOG	1	0.900	-	-		E1_COG0162
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2730
Inparanoid	1	1.050	396	1.000	Inparanoid score	I318
Isobase	1	0.950	-	0	Normalized mean entropy	S611
OMA	1	1.010	-	-		QHG54288
OrthoFinder	1	1.000	-	-		FOG0000771
OrthoInspector	1	1.000	-	-		oto99686
orthoMCL	1	0.900	-	-		OOG6_101224
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1461
SonicParanoid	1	1.000	-	-		X2335
TreeFam	1	0.960	-	-
	14	13.710