DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS and MSM1

DIOPT Version :9

Sequence 1:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_011687.1	Gene:	MSM1 / 853081	SGDID:	S000003403	Length:	575	Species:	Saccharomyces cerevisiae

Alignment Length:	344	Identity:	63/344 - (18%)
Similarity:	121/344 - (35%)	Gaps:	92/344 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITPAEKKALITRNLQE--TLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGC 66
            |.||.|:..|.:.|:.  ||.|..:::..|    ::.||..|...|....:|....:.::|.:..
Yeast   199 IFPASKRDQILKELETGGTLPDLSISRPSA----RLKWGIPTPNDPSQKVYVWFDALCNYLSSIG 259

  Fly    67 EVTILFADL-----HAYLDNMKAPWSLL-----ELR-----------TKYYEQVIKAMLSSIGVP 110
            .:..:.::.     ..|.|.......||     |::           .|::.....:.|.:.|:|
Yeast   260 GIPSILSNATEVVSRHYSDKSNVKGQLLIPYPKEVQRNTIHVIGKDIAKFHTVYWPSFLLAAGLP 324

  Fly   111 LEKLKFVKG----SDYQLSKEYTLDVYKLSSVVTQHD-AKKAGAEVVKQVEYPLLSGLLYPGLQA 170
            |.:...|.|    :..::||       .|.:||...| |:..||::|:..              .
Yeast   325 LPRQIVVHGHWLCNGMKMSK-------SLGNVVDPIDMARYYGADIVRWF--------------L 368

  Fly   171 LDEEYLKVDAQFGGVDQRKIFTFSEKYLPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKI---- 231
            |:...|:.|..|   .:.|::...|..:.:.|         .::....|.|.:......|.
Yeast   369 LENSKLEEDGDF---QEAKLYETRELLVSKWG---------NLINRCCGSKFNIERAVMKFSDKA 421

  Fly   232 ---------------DLLDSPANVKKKLKKAFCEPGNIADNGLLSFVKHVLFSLFKEGEGFEVN- 280
                           :.:::.|.:..|.::.|.|  .||.......::|| :|:..:......|
Yeast   422 NFQFQEIFQNEPIVSERIENLAKLLNKSQEVFDE--KIAIFQYPQLLRHV-WSIINDANTLVQNS 483

  Fly   281 ----REAEHGGDVTFLKYE 295
                ||.:...::.||..|
Yeast   484 KPWERELDQQDNIIFLAME 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	60/340 (18%)
		tyrS	12..332	CDD:272976	59/336 (18%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198
MSM1	NP_011687.1	metG	15..550	CDD:273058	63/344 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900