DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TyrRS and yars2

DIOPT Version :9

Sequence 1:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001137392.1	Gene:	yars2 / 556702	ZFINID:	ZDB-GENE-030131-6268	Length:	474	Species:	Danio rerio

Alignment Length:	350	Identity:	59/350 - (16%)
Similarity:	117/350 - (33%)	Gaps:	66/350 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ITPAEKKALITRNLQETLGDDKLTKILAERDLKIYWG-TATTGKPHVAYFVPMSKIADFLKAGCE 67
            ::....:.|:..:..|.....::..:|......||.| ..|....|....:.:..:..|..||..
Zfish    39 LSSLHNRGLLKDSFPEVAAQAEIPDLLRSGPQSIYCGFDPTADSLHAGNLLAIIGLLHFRSAGHH 103

  Fly    68 VTILFADLHAYLDNMKAPWSLLE-LRTKYYEQVIKAMLSSI--------------GVPLEKLKFV 117
            :..|.....|.:.:.....:..| |.....::..:.:|.|:              ...|.:|..:
Zfish   104 IIALLGGATAQIGDPSGRQTERERLSPAAVQENARGILESLHRIFTHHELYFCPDSSRLGRLTVL 168

  Fly   118 KG----SDYQLSKEYTLDV---YKLSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEY 175
            ..    .||.| .|:..:|   :::.:::::|..:..    :|..|....:...|...||.|...
Zfish   169 NNRSWYKDYDL-LEFFSEVGRSFRMGTMLSRHSVQTR----LKSAEGMSFTEFSYQLFQAFDFYQ 228

  Fly   176 LK----VDAQFGGVDQRKIFTFSEKYLPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKIDLLDS 236
            |.    ...|.||.||........:::.:...|:......|:|....|.|:..:..::.  .|:.
Zfish   229 LHQLHGCRIQLGGTDQLGNIMSGHEFIHRKTGEEVYGLTVPLVTTSMGDKLGKTAGNAV--WLNR 291

  Fly   237 PANVKKKLKKAFCEPGNIADNGLLSFVKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYY 301
            ......:..:.|.   .:.||.:..::|     ||                  |||...::|...
Zfish   292 DKTSPFEFYQYFL---RLPDNSVERYLK-----LF------------------TFLSLSEVENLM 330

  Fly   302 AEDKLHPGD------LKATVEKYIN 320
            .:.:..||.      |.|.|.|.::
Zfish   331 EQQRKDPGKRIAHKRLAAEVTKLVH 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	59/345 (17%)
		tyrS	12..332	CDD:272976	59/341 (17%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198
yars2	NP_001137392.1	PRK05912	43..471	CDD:235645	59/345 (17%)
yars2	NP_001137392.1	TyrRS_core	70..353	CDD:173902	55/315 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0162
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900