Protein Alignment TyrRS and yars1

DIOPT Version :10

• Sequence 1: NP_648895.1
• Gene: TyrRS / 39829
• FlyBaseID: FBgn0027080
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_001004987.1
• Gene: yars1 / 448444
• XenbaseID: XB-GENE-491608
• Length: 528
• Species: Xenopus tropicalis
• Alignment Length: 527
• Identity: 348/527 - (66%)
• Similarity: 415/527 - (78%)
• Gaps: 8/527 - (1%)

  Fly     3 GITPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCE 67
            |:||..|..||||||||.||:||:.:||.||.|:|||||||||||||||||||||||||||||||
 Frog     4 GLTPEGKAQLITRNLQEVLGEDKMKEILKERPLRIYWGTATTGKPHVAYFVPMSKIADFLKAGCE 68

  Fly    68 VTILFADLHAYLDNMKAPWSLLELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLDV 132
            |||||||||||||||||||.||||||:||||||:|||.|||||||:|:|::|:::||||||||||
 Frog    69 VTILFADLHAYLDNMKAPWDLLELRTRYYEQVIQAMLQSIGVPLERLRFIRGTEFQLSKEYTLDV 133

  Fly   133 YKLSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFSEKY 197
            |:||||||||||||||||||||||:||||||||||||||||||||||||||||||||||||:|||
 Frog   134 YRLSSVVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFAEKY 198

  Fly   198 LPQLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGNIADNGLLSF 262
            ||.|||.||||.||||||||.|.|||||||:||||||||||:|||||||||||||||.:||:|||
 Frog   199 LPALGYAKRIHLMNPMVPGLTGAKMSSSEEESKIDLLDSPADVKKKLKKAFCEPGNIENNGVLSF 263

  Fly   263 VKHVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYINRLLDPIR 327
            |:||||.|..|   |.|.|:.:.||:.|:..:|.|||.:.|..:|||||||:|||.:|:||||||
 Frog   264 VRHVLFPLKSE---FVVLRDEKFGGNKTYTDFETLEKDFTEQLVHPGDLKASVEKALNKLLDPIR 325

  Fly   328 KAFENPELQKLSAAAYPPPAKVKA---GAAPAAGADEDAPHRLDIRVGKVVEVARHPDADTLYVL 389
            :.|.:||::|||..|||..:|.|.   |:...:|.:|..|..||:||||::.|.:|||||:|||.
 Frog   326 EKFNSPEMKKLSNDAYPGASKQKTVPKGSTKNSGPEEIDPSLLDLRVGKILSVRQHPDADSLYVE 390

  Fly   390 KIDLAEAQPRTIISGLVKFVTEEELNQRLVAVLCNLKPSKMRGILSEGMVLCTS-NADHTVVEPI 453
            .:|:.|..||.::||||::|..::|..|.|.:||||||.|||||.|:||:||.| ..:...|||:
 Frog   391 SVDVGEENPRCVVSGLVQYVPSDQLLGRSVVLLCNLKPQKMRGIESQGMLLCASTEGEQKQVEPL 455

  Fly   454 VLPATATAGSRLSFEGF-SGTPDEQLNPKKKVWEKLSADFKTNSDGLAVWKDNFLLTPEGEKLSS 517
            ..|..:..|.|:..||: :|.|:.:|.|||||:|||..||:.:.|..|.||....||..|.....
 Frog   456 DPPTGSAPGERIYIEGYENGEPEGELKPKKKVFEKLQVDFRISDDLCAQWKGKNFLTKLGSVTCK 520

  Fly   518 KLANCSI 524
            .|...||
 Frog   521 TLRGGSI 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:469580	256/325 (79%)
		PLN02610	<366..525	CDD:215329	75/161 (47%)
yars1	NP_001004987.1	nt_trans	8..337	CDD:469580	259/331 (78%)
		'HIGH' region. /evidence=ECO:0000250|UniProtKB:P54577	44..52		7/7 (100%)
		'KMSKS' region. /evidence=ECO:0000250|UniProtKB:P54577	222..226		3/3 (100%)
		Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:P54577	242..247		4/4 (100%)
		PLN02610	<271..528	CDD:215329	120/260 (46%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..364		11/28 (39%)