Protein Alignment TyrRS and MARS1

DIOPT Version :10

• Sequence 1: NP_648895.1
• Gene: TyrRS / 39829
• FlyBaseID: FBgn0027080
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_004981.2
• Gene: MARS1 / 4141
• HGNCID: 6898
• Length: 900
• Species: Homo sapiens
• Alignment Length: 464
• Identity: 99/464 - (21%)
• Similarity: 162/464 - (34%)
• Gaps: 136/464 - (29%)

  Fly    13 ITRN-LQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIAD-FLKAGCEVTILFADL 75
            |||: |::.|....:|     ||||  |||.          ||:....| ......:.||.:..:
Human   481 ITRSWLRDGLKPRCIT-----RDLK--WGTP----------VPLEGFEDKVFYVWFDATIGYLSI 528

  Fly    76 HA-YLDNMKAPWSLLELRTKYYEQV-IKAMLSSIGVPLEKLKF---VKGSDYQLSKEYTLDVYKL 135
            .| |.|..:..|       |..||| :...::...||...|.|   ..|::    ..|||..:.:
Human   529 TANYTDQWERWW-------KNPEQVDLYQFMAKDNVPFHSLVFPCSALGAE----DNYTLVSHLI 582

  Fly   136 SSVVTQHD----AKKAGAEVVKQVEYPLLSG---------LLYPGLQALDEEYLKVDAQFGGVDQ 187
            ::....::    :|..|..|...:...  :|         |||...:..|..:...|.
Human   583 ATEYLNYEDGKFSKSRGVGVFGDMAQD--TGIPADIWRFYLLYIRPEGQDSAFSWTDL------- 638

  Fly   188 RKIFTFSEKYLPQLGYEKRIHFMN---PMVPGLAGG---KMSSSEEDSKIDLLDSPANVKKKLK- 245
              :...:.:.|..||     :|:|   ..|....||   :|..:.:|.::     .|:|..:|:
Human   639 --LLKNNSELLNNLG-----NFINRAGMFVSKFFGGYVPEMVLTPDDQRL-----LAHVTLELQH 691

  Fly   246 -KAFCEPGNIAD--NGLLSFVKH-----VLFSLFKEGEGFEVNREAEHGGDVTFLKYE------- 295
             ....|...|.|  ..:|:..:|     .:...:|..:|.|.:|  :..|.||.|...
Human   692 YHQLLEKVRIRDALRSILTISRHGNQYIQVNEPWKRIKGSEADR--QRAGTVTGLAVNIAALLSV 754

  Fly   296 DLEKY--------YAEDKLHPGDLKATVEKYINRL--------LDPIRKAFENPELQKL------ 338
            .|:.|        .|:.:|.|......:..::..|        :.|:.:..||.:::.|
Human   755 MLQPYMPTVSATIQAQLQLPPPACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGG 819

  Fly   339 -SAAAYPPPAKVK--AGAAP---AAGADEDAPHRLDIRVGKVVEVARHPDAD---------TLYV 388
             .|...|.||.|:  ..|.|   .|..||..      :.|.:|...:...||         .|..
Human   820 GQAKTSPKPAVVETVTTAKPQQIQALMDEVT------KQGNIVRELKAQKADKNEVAAEVAKLLD 878

  Fly   389 LKIDLAEAQ 397
            ||..||.|:
Human   879 LKKQLAVAE 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:469580	78/378 (21%)
		PLN02610	<366..525	CDD:215329	10/41 (24%)
MARS1	NP_004981.2	GST_N_5	1..74	CDD:436537
		GST_C_MetRS_N	77..179	CDD:198340
		PLN02610	251..893	CDD:215329	99/464 (21%)
		'HIGH' region	273..283
		'KMSKS' region	593..597		0/3 (0%)