DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TyrRS and Yars1

DIOPT Version :9

Sequence 1:	NP_648895.1	Gene:	TyrRS / 39829	FlyBaseID:	FBgn0027080	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001020867.2	Gene:	Yars1 / 313047	RGDID:	1307616	Length:	564	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	354/513 - (69%)
Similarity:	416/513 - (81%)	Gaps:	8/513 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TPAEKKALITRNLQETLGDDKLTKILAERDLKIYWGTATTGKPHVAYFVPMSKIADFLKAGCEVT 69
            :|.||..||||||||.||::||.:||.||:||:||||||||||||||||||||||||||||||||
  Rat    42 SPEEKLHLITRNLQEVLGEEKLKEILKERELKVYWGTATTGKPHVAYFVPMSKIADFLKAGCEVT 106

  Fly    70 ILFADLHAYLDNMKAPWSLLELRTKYYEQVIKAMLSSIGVPLEKLKFVKGSDYQLSKEYTLDVYK 134
            |||||||||||||||||.||||||.|||.||||||.|||||||||||.||:|||||||||||||:
  Rat   107 ILFADLHAYLDNMKAPWELLELRTSYYENVIKAMLESIGVPLEKLKFTKGTDYQLSKEYTLDVYR 171

  Fly   135 LSSVVTQHDAKKAGAEVVKQVEYPLLSGLLYPGLQALDEEYLKVDAQFGGVDQRKIFTFSEKYLP 199
            |||:||||||||||||||||||:|||||||||||||||||||||||||||:||||||||:|||||
  Rat   172 LSSLVTQHDAKKAGAEVVKQVEHPLLSGLLYPGLQALDEEYLKVDAQFGGIDQRKIFTFAEKYLP 236

  Fly   200 QLGYEKRIHFMNPMVPGLAGGKMSSSEEDSKIDLLDSPANVKKKLKKAFCEPGNIADNGLLSFVK 264
            .|||.||:|.||||||||.|.|||||||:|||||||...:||||||||||||||:.:||:|||||
  Rat   237 TLGYSKRVHLMNPMVPGLTGSKMSSSEEESKIDLLDRKEDVKKKLKKAFCEPGNVENNGVLSFVK 301

  Fly   265 HVLFSLFKEGEGFEVNREAEHGGDVTFLKYEDLEKYYAEDKLHPGDLKATVEKYINRLLDPIRKA 329
            ||||.|..|   |.:.|:.:.||:.|:..|::|||.:|.:.:||||||.:||..:|:||||||:.
  Rat   302 HVLFPLKSE---FVILRDEKWGGNKTYTIYQELEKDFAAEVVHPGDLKNSVEVALNKLLDPIREK 363

  Fly   330 FENPELQKLSAAAYPPPAKVK---AGAAPAAGADEDAPHRLDIRVGKVVEVARHPDADTLYVLKI 391
            |..|.|:||::||||.|:|.|   .|.|.::..:|..|.||||||||::.|.:|||||:|||.||
  Rat   364 FNTPALKKLASAAYPDPSKQKPTAKGPAKSSEPEEIIPSRLDIRVGKILSVEKHPDADSLYVEKI 428

  Fly   392 DLAEAQPRTIISGLVKFVTEEELNQRLVAVLCNLKPSKMRGILSEGMVLCTS-NADHTVVEPIVL 455
            |:.||:|||::||||:||.:|||..|||.|||||||.||||:.|:||:||.| ......|||:..
  Rat   429 DVGEAEPRTVVSGLVQFVPKEELQDRLVVVLCNLKPQKMRGVDSQGMLLCASVEGVSRQVEPLDP 493

  Fly   456 PATATAGSRLSFEGF-SGTPDEQLNPKKKVWEKLSADFKTNSDGLAVWKDNFLLTPEG 512
            ||.:..|.|:..:|: .|.|||:|.|||||:|||.||||.:.|.:|.||....:|..|
  Rat   494 PAGSAPGERVFVQGYEKGQPDEELKPKKKVFEKLQADFKISDDCVAQWKQTNFMTKLG 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TyrRS	NP_648895.1	nt_trans	8..334	CDD:294020	253/325 (78%)
		tyrS	12..332	CDD:272976	251/319 (79%)
		tRNA_bind_EMAP-II_like	364..466	CDD:239198	62/102 (61%)
Yars1	NP_001020867.2	nt_trans	44..364	CDD:294020	252/322 (78%)
		tyrS	45..364	CDD:272976	252/321 (79%)
		tRNA_bind_EMAP-II_like	401..504	CDD:239198	62/102 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166354184
Domainoid	1	1.000	472	1.000	Domainoid score	I424
eggNOG	1	0.900	-	-		E1_COG0143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2730
Inparanoid	1	1.050	698	1.000	Inparanoid score	I648
OMA	1	1.010	-	-		QHG54288
OrthoDB	1	1.010	-	-		D557463at33208
OrthoFinder	1	1.000	-	-		FOG0000771
OrthoInspector	1	1.000	-	-		oto97257
orthoMCL	1	0.900	-	-		OOG6_101224
Panther	1	1.100	-	-	LDO	PTHR11586
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2335
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770