DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRS-m and GLN4

DIOPT Version :9

Sequence 1:	NP_648894.2	Gene:	GluRS-m / 39828	FlyBaseID:	FBgn0036629	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_014811.3	Gene:	GLN4 / 854339	SGDID:	S000005694	Length:	809	Species:	Saccharomyces cerevisiae

Alignment Length:	391	Identity:	97/391 - (24%)
Similarity:	154/391 - (39%)	Gaps:	90/391 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 NPRM---LMQQCLRHAHSQVRVRFAPSPTGYLHLGGLRTALYNFLYARHLGGKFLLRIEDTDQTR 66
            ||:.   ||::.|.....:||.||.|.|.||||:|..:..:.||.||::..|...||.:||:..:
Yeast   233 NPQAYPELMKEHLEVTGGKVRTRFPPEPNGYLHIGHSKAIMVNFGYAKYHNGTCYLRFDDTNPEK 297

  Fly    67 LVPGASERLVEDLLWAGIEIDEGPGFGGQLGP----YVQSQRTEIYSKAIEELLHNGTAYRCFCT 127
            ..|...|.:...:.|.|.:            |    |......|:|..| |.|:.||.||.|.||
Yeast   298 EAPEYFESIKRMVSWLGFK------------PWKITYSSDYFDELYRLA-EVLIKNGKAYVCHCT 349

  Fly   128 ERRLDLLRKEALRTRQVP---RYDNKCRHLTTSEVDSLLA---------KGTPYCIRFK--LTDH 178
            ..  ::.|...::....|   ||  .|:|...|...:|..         |.....:|.|  |...
Yeast   350 AE--EIKRGRGIKEDGTPGGERY--ACKHRDQSIEQNLQEFRDMRDGKYKPGEAILRMKQDLNSP 410

  Fly   179 EEPLDDLIYGKVHHNVSDNEGDPVVMKSDQFPTYHFANVVDDHLMGITHVLRGVEWQISTTKHLL 243
            ...:.|||..:|.:......|    .|...:|||.|.:.:.|.:..|||       .:.||:..|
Yeast   411 SPQMWDLIAYRVLNAPHPRTG----TKWRIYPTYDFTHCLVDSMENITH-------SLCTTEFYL 464

  Fly   244 LYKAFGW--------QPP--KFGHLPLLVNADGTKLSKRQ-------------GD---IGIQHFR 282
            ..:::.|        :|.  ::|.|    |..||.||||:             .|   ..::..|
Yeast   465 SRESYEWLCDQVHVFRPAQREYGRL----NITGTVLSKRKIAQLVDEKFVRGWDDPRLFTLEAIR 525

  Fly   283 ERGYFPQALVNYVVSAGGGFEHRTNAKQQLLSMQALHEQFHIERVNSHPSRLNPELLDDLNRLEI 347
            .||..|.|:::::.:.|        ......::|.:..:   ..|..:.....|.|:..|:.:|:
Yeast   526 RRGVPPGAILSFINTLG--------VTTSTTNIQVVRFE---SAVRKYLEDTTPRLMFVLDPVEV 579

  Fly   348 V 348
            |
Yeast   580 V 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRS-m	NP_648894.2	gltX	19..500	CDD:234953	92/374 (25%)
		GluRS_core	21..349	CDD:173905	92/372 (25%)
		Ribosomal_L7_L12	<442..503	CDD:305167
GLN4	NP_014811.3	tRNA_synt_1c_R1	5..163	CDD:398315
		tRNA_synt_1c_R2	166..244	CDD:398314	4/10 (40%)
		glnS	252..807	CDD:273079	92/372 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810