DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GluRS-m and GUS1

DIOPT Version :9

Sequence 1:	NP_648894.2	Gene:	GluRS-m / 39828	FlyBaseID:	FBgn0036629	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_011269.2	Gene:	GUS1 / 852606	SGDID:	S000003214	Length:	708	Species:	Saccharomyces cerevisiae

Alignment Length:	519	Identity:	112/519 - (21%)
Similarity:	198/519 - (38%)	Gaps:	147/519 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QVRVRFAPSPTGYLHLGGLRTALYNFLYARHLGGKFLLRIEDTDQTRLVPGASERLVEDLLWAGI 84
            :|..||.|.|:||||:|..:.||.|..:|:...||.::|.:||:.::......:.::|||...||
Yeast   201 EVVTRFPPEPSGYLHIGHAKAALLNQYFAQAYKGKLIIRFDDTNPSKEKEEFQDSILEDLDLLGI 265

  Fly    85 EIDEGPGFGGQLGPYVQSQRTEIYSKAIEELLHNGTAYRCFCTERRLDLLRKEALRTRQVPRYDN 149
            :        |....|......|:|...: :::.:|.||   |.:...:.:|:|.:......|.|.
Yeast   266 K--------GDRITYSSDYFQEMYDYCV-QMIKDGKAY---CDDTPTEKMREERMDGVASARRDR 318

  Fly   150 KCR---HLTTSEVDSLLAKGTPYCIRFKLTDHEEPLDDLIYGKVHHNVSDNEGDPVVMKSDQ--- 208
            ...   .:.|.|:.:...:|...|:|.|: |::.             ::....|||:.:.:.
Yeast   319 SVEENLRIFTEEMKNGTEEGLKNCVRAKI-DYKA-------------LNKTLRDPVIYRCNLTPH 369

  Fly   209 ---------FPTYHFANVVDDHLMGITHVLRGVEWQISTTKH------LLLYKAFGWQPPKFGHL 258
                     :|||.|...:.|.:.|:||.||.:|::....::      |.|.|...|...:
Yeast   370 HRTGSTWKIYPTYDFCVPIVDAIEGVTHALRTIEYRDRNAQYDWMLQALRLRKVHIWDFAR---- 430

  Fly   259 PLLVNADGTKLSKRQGD-------IG---------IQHFRERGYFPQALVNYVVSAGGGFEHRTN 307
               :|...|.||||:..       :|         ::..|.||...:.|.|:|:|.|.. .:..|
Yeast   431 ---INFVRTLLSKRKLQWMVDKDLVGNWDDPRFPTVRGVRRRGMTVEGLRNFVLSQGPS-RNVIN 491

  Fly   308 AKQQLLSMQALHEQFHIERVNSHPSRLNPELLDDLNRLEIVQRLSGNESRTKLVNEVQQLVKEAY 372
            .:..|:  .|.:::........|.:.:||          :...|.|:|:       .|:...|..
Yeast   492 LEWNLI--WAFNKKVIDPIAPRHTAIVNP----------VKIHLEGSEA-------PQEPKIEMK 537

  Fly   373 PQH-SNLDLAEEHIL------------DVLN---------WSS-------------KRLTLLQDL 402
            |:| .|..:.|:.::            ||:|         |.:             .:|.|..|.
Yeast   538 PKHKKNPAVGEKKVIYYKDIVVDKDDADVINVDEEVTLMDWGNVIITKKNDDGSMVAKLNLEGDF 602

  Fly   403 TSSKLSFLWVKPSDFQIKDLTAEQLA---HLL------------QLINAIQDFHKD---ELNVK 448
            ..:|....|:..:    ||:....|.   ||:            ..:....:||.|   :||||
Yeast   603 KKTKHKLTWLADT----KDVVPVDLVDFDHLITKDRLEEDESFEDFLTPQTEFHTDAIADLNVK 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRS-m	NP_648894.2	gltX	19..500	CDD:234953	112/519 (22%)
		GluRS_core	21..349	CDD:173905	82/364 (23%)
		Ribosomal_L7_L12	<442..503	CDD:305167	5/10 (50%)
GUS1	NP_011269.2	GST_C_family	72..>128	CDD:413470
GUS1	NP_011269.2	gltX_arch	102..696	CDD:273091	112/519 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810