Protein Alignment GluRS-m and Ears2

DIOPT Version :10

• Sequence 1: NP_648894.2
• Gene: GluRS-m / 39828
• FlyBaseID: FBgn0036629
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_080416.1
• Gene: Ears2 / 67417
• MGIID: 1914667
• Length: 523
• Species: Mus musculus
• Alignment Length: 498
• Identity: 238/498 - (47%)
• Similarity: 324/498 - (65%)
• Gaps: 31/498 - (6%)

  Fly    21 VRVRFAPSPTGYLHLGGLRTALYNFLYARHLGGKFLLRIEDTDQTRLVPGASERLVEDLLWAGIE 85
            |||||||||||:||||||||||||:::|:...|.|:||:|||||:||||||:|.:.:.|.||||.
Mouse    37 VRVRFAPSPTGFLHLGGLRTALYNYIFAKKHQGSFILRLEDTDQSRLVPGAAESIEDMLEWAGIP 101

  Fly    86 IDEGPGFGGQLGPYVQSQRTEIYSKAIEELLHNGTAYRCFCTERRLDLLRKEALRTRQVPRYDNK 150
            .||.|..||..|||.||||..:|::|.|.||.:|.||.|||..:||:||:|||||:||.|||||:
Mouse   102 PDESPRRGGPAGPYCQSQRLALYAQATEALLRSGAAYPCFCLPQRLELLKKEALRSRQTPRYDNR 166

  Fly   151 CRHLTTSEVDSLLAKGTPYCIRFKLTDHEEPLDDLIYGKVHHNVSDNEGDPVVMKSDQFPTYHFA 215
            ||:|:.::|...||......|||:|.:......||:||...|.|:..|||||::|||.|||||.|
Mouse   167 CRNLSQAQVAQKLAVDPKPAIRFRLEEAVPAFQDLVYGWTQHEVASVEGDPVILKSDGFPTYHLA 231

  Fly   216 NVVDDHLMGITHVLRGVEWQISTTKHLLLYKAFGWQPPKFGHLPLLVNADGTKLSKRQGDIGIQH 280
            .|||||.|.|:|||||.||.:||:||||||:|.|||||:|.|||||:|.||:|||||||||.::|
Mouse   232 CVVDDHHMSISHVLRGSEWLVSTSKHLLLYQALGWQPPRFAHLPLLLNRDGSKLSKRQGDIFLEH 296

  Fly   281 FRERGYFPQALVNYVVSAGGGFEHRTNAKQQL-LSMQALHEQFHIERVNSHPSRLNPELLDDLNR 344
            |...|:.|:||::.:.:.|.||     |:.|: .::..|..||.:.|:..|.:.|:.|.|.:.||
Mouse   297 FAATGFLPEALLDIITNCGSGF-----AENQMGRTLPELITQFDLTRITCHSALLDLEKLPEFNR 356

  Fly   345 LEIVQRLSGNESRTKLVNEVQQLVKEAYPQHSNLDLAEEHILD------VLNWSSKRLTLLQDLT 403
            |.:.:.:|....|.:||.::|.|||||:    ..:|..:.:||      :|......::.||||.
Mouse   357 LHLRRLVSSETQRPQLVEKLQGLVKEAF----GSELQNKDVLDPAYMERILLLRQGHISRLQDLV 417

  Fly   404 SSKLSFLWVKPSDFQIK--------DLTAEQLAHLLQL--INAIQDFHKDELNVKLKSFAQ-KEN 457
            |...|:||.:|:..:.:        |:.|::|..||:.  ::..||.    ||.:||..:: .|.
Mouse   418 SPVYSYLWTRPAVHRSELGASSENVDVIAKRLLGLLERPGLSLTQDV----LNRELKKLSEGLEG 478

  Fly   458 IKFPLMMKTLRAALSGLKEGPGVAEMMEILGKSVTLERLKEAL 500
            .|...:||.||.||||..:||.|||||..||.....||:::.|
Mouse   479 AKHSSVMKLLRMALSGQLQGPPVAEMMVSLGPKEVRERIQKVL 521

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
GluRS-m	NP_648894.2	GlnS	19..500	CDD:439779	237/496 (48%)
Ears2	NP_080416.1	GlnS	33..521	CDD:439779	237/496 (48%)
		'HIGH' region	45..53		6/7 (86%)
		'KMSKS' region	284..288		3/3 (100%)