DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRS-m and EPRS1

DIOPT Version :9

Sequence 1:	NP_648894.2	Gene:	GluRS-m / 39828	FlyBaseID:	FBgn0036629	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_004437.2	Gene:	EPRS1 / 2058	HGNCID:	3418	Length:	1512	Species:	Homo sapiens

Alignment Length:	556	Identity:	116/556 - (20%)
Similarity:	204/556 - (36%)	Gaps:	166/556 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 QVRVRFAPSPTGYLHLGGLRTALYNFLYARHLGGKFLLRIEDTDQTRLVPGASERLVEDLLWAGI 84
            :|.|||.|..:||||:|..:.||.|..|..:..||.::|.:||:..:......:.::||:....|
Human   197 KVTVRFPPEASGYLHIGHAKAALLNQHYQVNFKGKLIMRFDDTNPEKEKEDFEKVILEDVAMLHI 261

  Fly    85 EIDEGPGFGGQLGPYVQSQRTEIYSKAIEELLHNGTAYRCFCTERRLDLLRKEALRTRQVPRYDN 149
            :.|:..         ..|...|...|..|:|:..|.||        :|....|.::..:..|.|:
Human   262 KPDQFT---------YTSDHFETIMKYAEKLIQEGKAY--------VDDTPAEQMKAEREQRIDS 309

  Fly   150 KCR------HLTTSEVDSLLAKGTPY----CIRFKLTDHEEPLDDLIYGKVHHNVSDNEG---DP 201
            |.|      :|...|.   :.||:.:    |:|.|:                 ::|.|.|   ||
Human   310 KHRKNPIEKNLQMWEE---MKKGSQFGQSCCLRAKI-----------------DMSSNNGCMRDP 354

  Fly   202 VVM------------KSDQFPTYHFANVVDDHLMGITHVLRGVEWQISTTKHLLLYKAFGWQPPK 254
            .:.            |.:.:|||.||..:.|.:.|:||.||..|:.....:...:.:|.|.:.|.
Human   355 TLYRCKIQPHPRTGNKYNVYPTYDFACPIVDSIEGVTHALRTTEYHDRDEQFYWIIEALGIRKPY 419

  Fly   255 FGHLPLLVNADGTKLSKR-------QGDIG---------IQHFRERGYFPQALVNYVVSAGG--- 300
            ......| |.:.|.||||       :|.:.         ::....||...:.|..::.:.|.
Human   420 IWEYSRL-NLNNTVLSKRKLTWFVNEGLVDGWDDPRFPTVRGVLRRGMTVEGLKQFIAAQGSSRS 483

  Fly   301 ----------GFEHR----------TNAKQQLLSMQALHEQFHIERVNSHPSRLNPELLDDLNRL 345
                      .|..:          ...|::::.:.....|..::.|..||.  |||:  .|..:
Human   484 VVNMEWDKIWAFNKKVIDPVAPRYVALLKKEVIPVNVPEAQEEMKEVAKHPK--NPEV--GLKPV 544

  Fly   346 EIVQR--LSGNESRTKLVNEVQQLVKEAYPQHSNLDLAEEHILDVLNWSSKRLTLLQDLTSSKLS 408
            ....:  :.|.::.|                     .:|..::..:||.:..:|.:.
Human   545 WYSPKVFIEGADAET---------------------FSEGEMVTFINWGNLNITKIH-------- 580

  Fly   409 FLWVKPSDFQIKDLTAEQLAHLLQLINAIQDFHKDELNVKLKSFAQKEN-IKFPLMMKTLRAALS 472
                |.:|.:|..|.|:     |.|.|  :|:.|   ..|:...|:..: :..|::..|....::
Human   581 ----KNADGKIISLDAK-----LNLEN--KDYKK---TTKVTWLAETTHALPIPVICVTYEHLIT 631

  Fly   473 GLKEGPGVAEMMEILGKSVTLERLKEALPKESLHLE 508
                       ..:|||.   |..|:.:.|.|.|.|
Human   632 -----------KPVLGKD---EDFKQYVNKNSKHEE 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRS-m	NP_648894.2	gltX	19..500	CDD:234953	112/546 (21%)
		GluRS_core	21..349	CDD:173905	87/391 (22%)
		Ribosomal_L7_L12	<442..503	CDD:305167	10/61 (16%)
EPRS1	NP_004437.2	PLN02907	13..711	CDD:215492	116/556 (21%)
		GST_C_GluProRS_N	74..157	CDD:198342
		Glutamate--tRNA ligase	164..759		116/556 (21%)
		tRNA-synt_1c	197..502	CDD:279135	78/342 (23%)
		'HIGH' region	204..214		5/9 (56%)
		'KMSKS' region	432..436		2/3 (67%)
		tRNA-synt_1c_C	504..681	CDD:281883	38/211 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	709..744
		WHEP-TRS	753..805	CDD:278865
		3 X 57 AA approximate repeats	760..956
		WHEP-TRS	826..878	CDD:278865
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	869..900
		WEPRS_RNA	904..952	CDD:238473
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	956..1012
		Charged	959..991
		Proline--tRNA ligase	1007..1512
		PRK08661	1019..1512	CDD:236327
		ProRS_core_arch_euk	1023..1286	CDD:238401
		L-proline binding. /evidence=ECO:0000269\|PubMed:24100331, ECO:0007744\|PDB:4K87	1121..1123
		ProRS_anticodon_zinc	1292..1512	CDD:238439
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810