DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GluRS-m and EARS2

DIOPT Version :9

Sequence 1:	NP_648894.2	Gene:	GluRS-m / 39828	FlyBaseID:	FBgn0036629	Length:	511	Species:	Drosophila melanogaster
Sequence 2:	NP_001295140.1	Gene:	EARS2 / 124454	HGNCID:	29419	Length:	534	Species:	Homo sapiens

Alignment Length:	502	Identity:	235/502 - (46%)
Similarity:	321/502 - (63%)	Gaps:	33/502 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 VRVRFAPSPTGYLHLGGLRTALYNFLYARHLGGKFLLRIEDTDQTRLVPGASERLVEDLLWAGIE 85
            |||||||||||:||||||||||||:::|:...|.|:||:|||||||:||||:|.:.:.|.||||.
Human    37 VRVRFAPSPTGFLHLGGLRTALYNYIFAKKYQGSFILRLEDTDQTRVVPGAAENIEDMLEWAGIP 101

  Fly    86 IDEGPGFGGQLGPYVQSQRTEIYSKAIEELLHNGTAYRCFCTERRLDLLRKEALRTRQVPRYDNK 150
            .||.|..||..|||.||||.|:|::|.|.||..|.||.|||:.:||:||:|||||..|.|||||:
Human   102 PDESPRRGGPAGPYQQSQRLELYAQATEALLKTGAAYPCFCSPQRLELLKKEALRNHQTPRYDNR 166

  Fly   151 CRHLTTSEVDSLLAKGTPYCIRFKLTDHEEPLDDLIYGKVHHNVSDNEGDPVVMKSDQFPTYHFA 215
            ||:::..:|...|||.....|||:|........||:||...|.|:..|||||:||||.|||||.|
Human   167 CRNMSQEQVAQKLAKDPKPAIRFRLEQVVPAFQDLVYGWNRHEVASVEGDPVIMKSDGFPTYHLA 231

  Fly   216 NVVDDHLMGITHVLRGVEWQISTTKHLLLYKAFGWQPPKFGHLPLLVNADGTKLSKRQGDIGIQH 280
            .|||||.|||:|||||.||.:||.||||||:|.|||||.|.|||||:|.||:||||||||:.::|
Human   232 CVVDDHHMGISHVLRGSEWLVSTAKHLLLYQALGWQPPHFAHLPLLLNRDGSKLSKRQGDVFLEH 296

  Fly   281 FRERGYFPQALVNYVVSAGGGFEHRTNAKQQL-LSMQALHEQFHIERVNSHPSRLNPELLDDLNR 344
            |...|:.|.:|::.:.:.|.||     |:.|: .::..|..||::.:|..|.:.|:.|.|.:.||
Human   297 FAADGFLPDSLLDIITNCGSGF-----AENQMGRTLPELITQFNLTQVTCHSALLDLEKLPEFNR 356

  Fly   345 LEIVQRLSGNES-RTKLVNEVQQLVKEAYP-QHSNLD-LAEEHILDVLNWSSKRLTLLQDLTSSK 406
            |.: |||..||| |.:||.::|.||:||:. |..|.| |...::..:|......:..||||.|..
Human   357 LHL-QRLVSNESQRRQLVGKLQVLVEEAFGCQLQNRDVLNPVYVERILLLRQGHICRLQDLVSPV 420

  Fly   407 LSFLWVKPSDFQIK--------DLTAEQLAHLLQLINAIQDFHKDELNVKLKSFAQ-KENIKFPL 462
            .|:||.:|:..:.:        |:.|:::..||:  .:.....:|.||.:||..:: .|..|:..
Human   421 YSYLWTRPAVGRAQLDAISEKVDVIAKRVLGLLE--RSSMSLTQDMLNGELKKLSEGLEGTKYSN 483

  Fly   463 MMKTLRAALSG--LKEGPGVAEMME----------ILGKSVTLERLK 497
            :||.||.||||  :::|.|:...:|          :.|..:.:|..|
Human   484 VMKLLRMALSGQQVRQGHGLDCSLEPLIDPLNLHFLAGTELNIEYTK 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GluRS-m	NP_648894.2	gltX	19..500	CDD:234953	235/502 (47%)
		GluRS_core	21..349	CDD:173905	182/328 (55%)
		Ribosomal_L7_L12	<442..503	CDD:305167	21/69 (30%)
EARS2	NP_001295140.1	GluRS_core	36..361	CDD:173905	182/329 (55%)
		gltX	37..508	CDD:234953	231/478 (48%)
		Glutamate binding. /evidence=ECO:0000250	40..42		1/1 (100%)
		'HIGH' region	45..53		6/7 (86%)
		Glutamate binding. /evidence=ECO:0000250	228..232		2/3 (67%)
		'KMSKS' region	284..288		3/3 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152767
Domainoid	1	1.000	366	1.000	Domainoid score	I930
eggNOG	1	0.900	-	-		E1_COG0008
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6907
Inparanoid	1	1.050	434	1.000	Inparanoid score	I1706
Isobase	1	0.950	-	0	Normalized mean entropy	S1321
OMA	1	1.010	-	-		QHG52070
OrthoDB	1	1.010	-	-		D309193at33208
OrthoFinder	1	1.000	-	-		FOG0003395
OrthoInspector	1	1.000	-	-		oto90144
orthoMCL	1	0.900	-	-		OOG6_101161
Panther	1	1.100	-	-	LDO	PTHR43311
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1434
SonicParanoid	1	1.000	-	-		X2748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750