DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and TMS1

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_010390.3	Gene:	TMS1 / 851682	SGDID:	S000002512	Length:	473	Species:	Saccharomyces cerevisiae

Alignment Length:	457	Identity:	129/457 - (28%)
Similarity:	216/457 - (47%)	Gaps:	83/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAALGI---CSAAQCAMCCGGTAASMCCSACPSCTNAS------SSRFMYAFILLVGTVLGAIA 56
            |||.:.:   .:.:..|.|.||     |||...:.|.:|      .:|.:||..||:.:::..::
Yeast     1 MGAVISLPVSMAGSFVASCFGG-----CCSNLVTKTASSLGSSSLGTRLLYAVWLLLNSLISWVS 60

  Fly    57 LSPGLQDTLKKMPFCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLI 121
            .|.              :.|....|.....:|     :|    |:..|:|:.|.:.|...:::|:
Yeast    61 YSA--------------NKSILWPGKTCTGTG-----EC----GFFTVHRLNFALGCLHLILALV 102

  Fly   122 MLGVKSSRDPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIV 186
            :.||||:.|.|:.:||::|.|||::.....:.:..||:..:.....||.:..|..||||.|:::|
Yeast   103 LTGVKSTNDVRAALQNSWWSLKFILYLCLIVLSFVIPNDFYIFFSKWVSVPSGAIFILVGLILLV 167

  Fly   187 DFAHSLAE---NWIESAENSRGYY--YALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFIS 246
            ||||..||   :.:||.:....::  :.:.|.|.: |..|:....::|:.|.... |.:|:..::
Yeast   168 DFAHEWAETCISHVESEDEDSSFWQRFLVLGTTSM-YTASIIMTVVMYVMFCHQQ-CNMNQTAVT 230

  Fly   247 INLIFCLAISVISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNP-EKECNP-------GM 303
            :|||..:...|:|:.|.:||..|.|||.|||:|::|..|||.||:::.| :|.|||       ..
Yeast   231 VNLILTVITLVLSVNPKIQEANPKSGLAQSSMVSVYCTYLTMSAMSSEPDDKMCNPLVRSSGTRK 295

  Fly   304 FGMMEGFGNATTTAAPPTHTTRV----TFDTTNIIGLVVWL--------------LCILYNCISS 350
            |.::  .|:..|..|....|||.    .|..||..| .::|              ..:.|..|..
Yeast   296 FSII--LGSLFTFIAIAYTTTRAAANSAFQGTNTNG-AIYLGNDIEYEGLGGQTRNQLRYEAIKQ 357

  Fly   351 AVEVSKISHDNSEKREALSDTE-AGTD---GSGKPSTDTETEGVTYSWSMFHLVFVCASLYVMMT 411
            |||      :.|....||.||. .||.   |:.....|.|..|..|::::||::|..|:.::.:.
Yeast   358 AVE------EGSLPESALYDTAWLGTSSPTGAMDNQNDDERTGTKYNYTLFHVIFFLATQWIAIL 416

  Fly   412 LT 413
            ||
Yeast   417 LT 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	125/439 (28%)
TMS1	NP_010390.3	Serinc	12..467	CDD:397431	126/443 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346053
Domainoid	1	1.000	151	1.000	Domainoid score	I932
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41334
Inparanoid	1	1.050	153	1.000	Inparanoid score	I1105
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		oto100042
orthoMCL	1	0.900	-	-		OOG6_101085
Panther	1	1.100	-	-	LDO	PTHR10383
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1919
SonicParanoid	1	1.000	-	-		X262
TreeFam	1	0.960	-	-
	15	14.790