Protein Alignment TMS1 and SERINC4

DIOPT Version :9

• Sequence 1: NP_001261947.1
• Gene: TMS1 / 39827
• FlyBaseID: FBgn0028399
• Length: 467
• Species: Drosophila melanogaster
• Sequence 2: NP_001244960.1
• Gene: SERINC4 / 619189
• HGNCID: 32237
• Length: 518
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 144/468 - (30%)
• Similarity: 226/468 - (48%)
• Gaps: 82/468 - (17%)

  Fly     2 GAALGIC-----------SAAQCAMCCGGTA--ASMCCSACPSCTNASSSRFMYAFILLVGTVLG 53
            |.:||:.           .:..|.:||.|.|  ||.|.|..||.|.::.||..|..:.:..:.:.
Human    11 GTSLGLAQQHSGGSSVLVKSPFCQVCCCGPAPCASCCHSRWPSLTASTCSRLFYILLHVGASAIC 75

  Fly    54 AIALSPGLQDTL------KKMPFCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMA 112
            .:.||..:.:.:      .:||          ||..:.:.|.|   ||....|..||||||.|.|
Human    76 CLLLSRTVVERVWGKTHRIQMP----------SGLCAHLFGLS---DCPVLSGSGAVYRVCAGTA 127

  Fly   113 CFFALMSLIMLGVKSSRDPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAF 177
            .|..|.:::::.:.|...||:.:.|:||.||.|...|....|..|||....||..::|:.||.||
Human   128 TFHLLQAVLLVHLHSPTSPRAQLHNSFWLLKLLFLLGLCAIAFCIPDEHLFPAWHYIGICGGFAF 192

  Fly   178 ILVQLVIIVDFAHSLAENWIESAENSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINK 242
            ||:|||:|..||||..:||...|.....::.|:...||..|.::..|..||:.|:|...||.:||
Human   193 ILLQLVLITAFAHSWNKNWQTGAAQDCSWFLAVLLATLGFYSMAGVGAVLLFHYYTHPAGCLLNK 257

  Fly   243 FFISINLIFCLAISVISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKE--------- 298
            ..:|::|.||..||.:||.|.::.:.|.|||||:|:::.|.:|||:||:::.|.:.
Human   258 MLLSLHLCFCGLISFLSIAPCIRLKQPRSGLLQASVISCYIMYLTFSALSSRPPERVILQGQNHT 322

  Fly   299 -CNPGMFGMMEGFGNATTTAAPPTHTTRVTFDTTNIIGLVVWLLCILYNC--------ISSAVEV 354
             |.||:..|           .|.|....:...:.:|:     ..|:|:.|        :...:.:
Human   323 LCLPGLSKM-----------EPQTPDISLAMLSASIM-----YACVLFACNEASYLAEVFGPLWI 371

  Fly   355 SKISHDNSEK-------REALSDTEAGTDGSGKPSTDTET--------EGVTYSWSMFHLVFVCA 404
            .|:.....:|       .|.:...:....|:.:|: |.||        :.::|::|.||.||..|
Human   372 VKVYSYEFQKPSLCFCCPETVEADKGQRGGAARPA-DQETPPAPPVQVQHLSYNYSAFHFVFFLA 435

  Fly   405 SLYVMMTLTNWYN 417
            |||||:|||||::
Human   436 SLYVMVTLTNWFS 448

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	140/441 (32%)
SERINC4	NP_001244960.1	Serinc	37..477	CDD:281358	139/442 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158730
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860