Protein Alignment TMS1 and SERINC1

DIOPT Version :9

• Sequence 1: NP_001261947.1
• Gene: TMS1 / 39827
• FlyBaseID: FBgn0028399
• Length: 467
• Species: Drosophila melanogaster
• Sequence 2: NP_065806.1
• Gene: SERINC1 / 57515
• HGNCID: 13464
• Length: 453
• Species: Homo sapiens
• Alignment Length: 427
• Identity: 185/427 - (43%)
• Similarity: 260/427 - (60%)
• Gaps: 30/427 - (7%)

  Fly     1 MGAALGICSAAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTL 65
            ||:.||:||.|....|..|:|..:.|..|||..|::.:|.:||..||||..:..:.|.||:::.|
Human     1 MGSVLGLCSMASWIPCLCGSAPCLLCRCCPSGNNSTVTRLIYALFLLVGVCVACVMLIPGMEEQL 65

  Fly    66 KKMP-FCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSR 129
            .|:| ||.|...               .|.|...:||.||||:|||:|.|:.|:||:|:.||||.
Human    66 NKIPGFCENEKG---------------VVPCNILVGYKAVYRLCFGLAMFYLLLSLLMIKVKSSS 115

  Fly   130 DPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAE 194
            |||:.:.|.||..||.......|||.|||:|:|.....:||:.|...|||:|||:::|||||..|
Human   116 DPRAAVHNGFWFFKFAAAIAIIIGAFFIPEGTFTTVWFYVGMAGAFCFILIQLVLLIDFAHSWNE 180

  Fly   195 NWIESAE--NSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISV 257
            :|:|..|  |||.:|.||...|.|.|:|||..|.|.::|:|....|..||.|||:|::.|:..||
Human   181 SWVEKMEEGNSRCWYAALLSATALNYLLSLVAIVLFFVYYTHPASCSENKAFISVNMLLCVGASV 245

  Fly   258 ISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTH 322
            :||||.:||..|.|||||||::|:||:||||||:.|.||..|||.:..::   |..||:..|...
Human   246 MSILPKIQESQPRSGLLQSSVITVYTMYLTWSAMTNEPETNCNPSLLSII---GYNTTSTVPKEG 307

  Fly   323 TTRVTFDTTNIIGLVVWLLCILYNCI--SSAVEVSKISHDNSEKREALSDTEAGTDGSGKP---- 381
            .:...:....||||:::|||:.|:.|  |:..:|:|::. .|::...:.|..|.:|||.:.
Human   308 QSVQWWHAQGIIGLILFLLCVFYSSIRTSNNSQVNKLTL-TSDESTLIEDGGARSDGSLEDGDDV 371

  Fly   382 --STDTETEGVTYSWSMFHLVFVCASLYVMMTLTNWY 416
              :.|.|.:|||||:|.||.:...||||:||||||||
Human   372 HRAVDNERDGVTYSYSFFHFMLFLASLYIMMTLTNWY 408

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	178/412 (43%)
SERINC1	NP_065806.1	Serinc	17..451	CDD:397431	177/411 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158728
Domainoid	1	1.000	341	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41334
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm41859
orthoMCL	1	0.900	-	-		OOG6_101085
Panther	1	1.100	-	-	LDO	PTHR10383
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1919
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800