DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TMS1 and serinc4

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_698642.3	Gene:	serinc4 / 570112	ZFINID:	ZDB-GENE-121031-1	Length:	498	Species:	Danio rerio

Alignment Length:	484	Identity:	158/484 - (32%)
Similarity:	245/484 - (50%)	Gaps:	79/484 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 AAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTLKK-MPFCIN 73
            |.|...|||....|:|||.||...:::|:|.||....::...:..:.||..:.:.::: :|| .|
Zfish    21 AYQICCCCGPAPCSLCCSFCPPVKSSTSTRIMYTLFHILACTVSCLMLSKTVSEAVRENVPF-FN 84

  Fly    74 STSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSHIQNN 138
            .....:.|      ||    ||:..:||.||||||||.|||:.:|::.::.||||:|.|:.|.|.
Zfish    85 VVCDEAHG------GG----DCQMLVGYSAVYRVCFGTACFYLMMAIFLIDVKSSQDFRALIHNG 139

  Fly   139 FWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESAENS 203
            ||.|||:...|....|.|||..||..|..:||::||.:|||:||::|..|||:..:||:..|..:
Zfish   140 FWFLKFITMLGMIAAAFFIPTESFLHAWHYVGVVGGFSFILIQLILITAFAHTWNKNWLTGAAEN 204

  Fly   204 RGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAVQERL 268
            :.:|.|:...||..|.::....|.:|.|:|...||.:||..:..||..|..:|.|:|.|.||::.
Zfish   205 KRWYVAVMCATLFFYTIATMAFTFMYKYYTHPAGCHLNKALLWTNLALCTIMSFIAITPCVQQKK 269

  Fly   269 PHSGLLQSSLVTLYTVYLTWSAVANNPEKE----------CNPGMF-GMMEGFGNATTTAAPPTH 322
            |.||:||:|::..|.:|||:||:::.|.::          |.|.:. ..::..|||..
Zfish   270 PRSGILQASIICCYVMYLTFSALSSRPPEKVEYQGVNITICYPKVSRDEIQNEGNAVA------- 327

  Fly   323 TTRVTFDTTNIIGLVVWLLCILYNCISSA----------------VEVSKIS-----HDNSEKRE 366
                      |:|..:...|:|:.|..::                .|..|.|     .:..::.|
Zfish   328 ----------IMGAAIMYCCVLFACNEASYLAEVFGPFWMIKVYRYEFQKASCCFCCPEAEDEEE 382

  Fly   367 ALSDTEAGTDGSGKPSTDTETEGVTYSWSMFHLVFVCASLYVMMTLTNWYN-NFLFPQTSFGNRA 430
            .:.|...|.    :.....||:.|.||:..||.||..||||||||||||:: .....:|:|.:.:
Zfish   383 FVIDENKGC----QKVVHNETQRVAYSYFFFHFVFFLASLYVMMTLTNWFSYETAVLETTFTHGS 443

  Fly   431 VQRQRGFHVGQDRLQLAGC-----LHLWL 454
            ...   |.|     :|:.|     |:|||
Zfish   444 YST---FWV-----KLSSCWACVVLYLWL 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	146/433 (34%)
serinc4	XP_698642.3	Serinc	27..458	CDD:281358	152/470 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594692
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.860