DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and SERINC2

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_001185967.1	Gene:	SERINC2 / 347735	HGNCID:	23231	Length:	464	Species:	Homo sapiens

Alignment Length:	465	Identity:	180/465 - (38%)
Similarity:	270/465 - (58%)	Gaps:	65/465 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTLKKMPFCINSTSSY 78
            |.|..|:|..:.||.||:..|::.||.::.|.|.:|.::..|.||||::..|.|:|:....
Human    23 ASCLCGSAPCILCSCCPASRNSTVSRLIFTFFLFLGVLVSIIMLSPGVESQLYKLPWVCEE---- 83

  Fly    79 SSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSHIQNNFWPLK 143
            .:|..:.:.|   .:||...|||.||||:||..|.||...:|:||.|.||||||:.|||.||..|
Human    84 GAGIPTVLQG---HIDCGSLLGYRAVYRMCFATAAFFFFFTLLMLCVSSSRDPRAAIQNGFWFFK 145

  Fly   144 FLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESAE--NSRGY 206
            |||..|..:||.:||||||.....:.|::|...|||:|||:::|||||..:.|:..||  :||.:
Human   146 FLILVGLTVGAFYIPDGSFTNIWFYFGVVGSFLFILIQLVLLIDFAHSWNQRWLGKAEECDSRAW 210

  Fly   207 YYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAVQERLPHS 271
            |..|...|||.|:||:..:.|:::|:|..:||...|.|||:||.||:.:|:.::||.||:..|:|
Human   211 YAGLFFFTLLFYLLSIAAVALMFMYYTEPSGCHEGKVFISLNLTFCVCVSIAAVLPKVQDAQPNS 275

  Fly   272 GLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTHTTRVTFDTTNIIGL 336
            ||||:|::||||:::||||:::.||::|||.:...:   ||.|..|.|..:.|: .:|..:|:||
Human   276 GLLQASVITLYTMFVTWSALSSIPEQKCNPHLPTQL---GNETVVAGPEGYETQ-WWDAPSIVGL 336

  Fly   337 VVWLLCILYNCISSAVEVSKISHDNSEKRE--ALSDTE---------------AGTDGSGKPSTD 384
            :::|||.|:           ||..:|:.|:  :|..||               |..:|.   :.|
Human   337 IIFLLCTLF-----------ISLRSSDHRQVNSLMQTEECPPMLDATQQQQQVAACEGR---AFD 387

  Fly   385 TETEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSFGNRAVQRQRGFHVGQDRLQLAGC 449
            .|.:|||||:|.||...|.|||:|||||||||.                     .|:.|..::..
Human   388 NEQDGVTYSYSFFHFCLVLASLHVMMTLTNWYK---------------------PGETRKMISTW 431

  Fly   450 LHLWLEPCSA 459
            ..:|::.|::
Human   432 TAVWVKICAS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	174/419 (42%)
SERINC2	NP_001185967.1	Serinc	26..462	CDD:281358	178/462 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158727
Domainoid	1	1.000	341	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm41859
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870