DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TMS1 and serinc1

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_956021.1	Gene:	serinc1 / 325690	ZFINID:	ZDB-GENE-030131-4415	Length:	459	Species:	Danio rerio

Alignment Length:	438	Identity:	201/438 - (45%)
Similarity:	278/438 - (63%)	Gaps:	31/438 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAALGICSAAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTL 65
            |||.||:||.|....|..|:|..:.|..|||..|::.:|.:|||.:|:|..:..|.|.||::..|
Zfish     1 MGAVLGLCSMASWIPCLCGSAPCLLCGCCPSGNNSTVTRLIYAFFMLLGVGIACIMLMPGMEGQL 65

  Fly    66 KKMP-FCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSR 129
            ||:| ||       ..|..|::.|....|:|:..:||.||||||||||.||.|.||||:.||||:
Zfish    66 KKIPGFC-------EGGMGSSIPGVEGHVNCDVLVGYKAVYRVCFGMAMFFLLFSLIMVKVKSSQ 123

  Fly   130 DPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAE 194
            |||:.:.|.||..||.......:||.|||:|.|.....::|:.|...|||:|||:::|||||..|
Zfish   124 DPRAAVHNGFWFFKFAAATAITVGAFFIPEGPFTTVWFYIGMAGAFCFILIQLVLLIDFAHSWNE 188

  Fly   195 NWIESAE--NSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISV 257
            :|:|..|  |||.:|.||...|.:.|.|||..:.|.|:|:|.|.||..||.|||||::.|:..||
Zfish   189 SWVEKMEEGNSRCWYAALLSATAINYALSLMSLVLFYVYYTHSDGCTENKVFISINMLLCVGASV 253

  Fly   258 ISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTH 322
            :||||.:||..|.|||||||:|||||:||||||:.|.|::.|||.:.|:: |. |:|:    |..
Zfish   254 MSILPKIQESQPRSGLLQSSIVTLYTMYLTWSAMTNEPDRRCNPSLLGII-GL-NSTS----PAG 312

  Fly   323 TTRVT--FDTTNIIGLVVWLLCILYNCI--SSAVEVSK--ISHDNS---EKREALSDTEAGTDGS 378
            ..||.  :|...|:||:::|:|:||:.|  ||..:|:|  ::.|.|   |...|..:.|.| ||:
Zfish   313 QDRVVQWWDAQGIVGLILFLMCVLYSSIRNSSNTQVNKLTLTSDESALIEDGPAPENFEVG-DGT 376

  Fly   379 GKPSTDTETEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSF 426
            .: :.|.|.:|||||:|.||.:...||||:||||||||:    |.:::
Zfish   377 NR-AIDNEKDGVTYSYSFFHFMLFLASLYIMMTLTNWYS----PDSNY 419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	191/412 (46%)
serinc1	NP_956021.1	Serinc	17..457	CDD:281358	192/422 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594690
Domainoid	1	1.000	358	1.000	Domainoid score	I924
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41334
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2044
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm25272
orthoMCL	1	0.900	-	-		OOG6_101085
Panther	1	1.100	-	-	LDO	PTHR10383
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1919
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	17	16.800