DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and Serinc4

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_006234915.1	Gene:	Serinc4 / 311358	RGDID:	1566077	Length:	492	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	142/499 - (28%)
Similarity:	221/499 - (44%)	Gaps:	99/499 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSP-----------GLQDTLKKMP 69
            |||..:.:   |.|.|.|.::.||..|..:.:..:.:..:.||.           |:|     ||
  Rat    36 CCGPVSWT---SGCHSLTESTCSRLFYILLHMGASAICCLLLSKTVVERVWGKAHGIQ-----MP 92

  Fly    70 FCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSH 134
                      |...:.:.|.|   ||....|..||||||.|.|.|..|.:::::.:.|...||:.
  Rat    93 ----------SVLCAHLFGNS---DCPVLSGSGAVYRVCAGTATFHLLQAVLLVRLHSPTSPRAQ 144

  Fly   135 IQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIES 199
            :.|:||.||.|...|....|..|||....||..::|:.||..|||:|||:|..||.|..:||...
  Rat   145 LHNSFWSLKLLFLLGLCTAAFCIPDEHLFPAWHYIGICGGFTFILLQLVLITAFAQSWNKNWQTG 209

  Fly   200 AENSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAV 264
            |.....::..:...||..|.::..|..||:.::|...||.:||..:|::|.||..:|::||.|.:
  Rat   210 AAQDCSWFLGVLLATLGFYSMAGVGAVLLFHHYTHPDGCLLNKMLLSLHLCFCGLLSLLSIAPCI 274

  Fly   265 QERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKE----------CNPGMFGMMEGFGNATTTAAP 319
            :.|.|:|||||:|:::.|.:|||:||:::.|.:.          |.||...|.....:|:..
  Rat   275 RLRQPNSGLLQASIISCYIMYLTFSALSSRPPETIIFQGQNHTLCLPGQNKMEPQIPDASVA--- 336

  Fly   320 PTHTTRVTFDTTNIIGLVVWLLCILYNCISSA-----------VEVSKISHDNSEKREALSDTEA 373
                         :....:...|:|:.|..::           ::|.|..............|..
  Rat   337 -------------VFSASIMYACVLFACNEASYLAQLFGPLWIIKVYKYEFQKPSVCFCCPQTVE 388

  Fly   374 GTDGSGK----------PSTDTETEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSFGN 428
            ..||.|.          |:...:::.::||:|.||..|..||||||:|||||          |..
  Rat   389 PEDGQGSRARPADQETPPAAQVQSQHLSYSYSGFHFAFFLASLYVMVTLTNW----------FSY 443

  Fly   429 RAVQRQRGFHVGQDR---LQLAGC-------LHLWLEPCSAHCS 462
            ...:.::.|..|...   :::|.|       |.|.|.|..||.|
  Rat   444 EEAELEKTFTKGSWATFWVKVASCWACVLLYLGLLLAPLLAHHS 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	130/442 (29%)
Serinc4	XP_006234915.1	Serinc	36..471	CDD:281358	135/481 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860