DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TMS1 and SERINC5

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_011541606.1	Gene:	SERINC5 / 256987	HGNCID:	18825	Length:	543	Species:	Homo sapiens

Alignment Length:	436	Identity:	154/436 - (35%)
Similarity:	226/436 - (51%)	Gaps:	55/436 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CSAAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTLKK-MPFC 71
            |.|.|.|.|||....|:||..||....:.|:|||||...::..||..|.:|..:...:|: :||.
Human     5 CCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFF 69

  Fly    72 INSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSHIQ 136
            .:......:|.           .||..:||.|||||||||||||.:..|:.|.:.:|:..|:||.
Human    70 EDMCKGIKAGD-----------TCEKLVGYSAVYRVCFGMACFFFIFCLLTLKINNSKSCRAHIH 123

  Fly   137 NNFWPLKFLICFGAAIGAIFIPD-GSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESA 200
            |.||..|.|:......||.|||| .:|..|..:||.:||..||.:||:::|:|||...:||....
Human   124 NGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKWNKNWTAGT 188

  Fly   201 ENSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAVQ 265
            .:::.:|.:||.|||:.|.::..|:.|:.:::|....|..||..:.:|...||.||:::|.|.||
Human   189 ASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQ 253

  Fly   266 ERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTHTTRVTF-- 328
            .|.||||||||.:::.|..|||:||:::.|.:.       :::..|...|...|       .|
Human   254 NRQPHSGLLQSGVISCYVTYLTFSALSSKPAEV-------VLDEHGKNVTICVP-------DFGQ 304

  Fly   329 ------DTTNIIGLVVWLLCILYNCISSAVEVSKISHDNSEKREAL----------------SDT 371
                  :...|:|..:.:.||||:|::|   .::.|.|..:.|.|.                .||
Human   305 DLYRDENLVTILGTSLLIGCILYSCLTS---TTRSSSDALQGRYAAPELEIARCCFCFSPGGEDT 366

  Fly   372 EAGTDGSGKPST-DTETEGVTYSWSMFHLVFVCASLYVMMTLTNWY 416
            |....|...|.. ..|.:|..|.:|.||.||..||||||||:|||:
Human   367 EEQQPGKEGPRVIYDEKKGTVYIYSYFHFVFFLASLYVMMTVTNWF 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	150/428 (35%)
SERINC5	XP_011541606.1	Serinc	13..413	CDD:281358	150/428 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158729
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.860