DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and Serinc2

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_006503126.1	Gene:	Serinc2 / 230779	MGIID:	1919132	Length:	459	Species:	Mus musculus

Alignment Length:	463	Identity:	177/463 - (38%)
Similarity:	263/463 - (56%)	Gaps:	66/463 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTLKKMPF-CINSTSS 77
            |.|..|:|..:.|..|||..|::.||.::...|.:|.::..|.||||::..|.|:|: |.:.|..
Mouse    23 ASCLCGSAPCILCGCCPSTRNSTVSRLLFTSFLFLGVLVSIIMLSPGVESQLYKLPWVCEDRTQQ 87

  Fly    78 YSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSHIQNNFWPL 142
                  ..|..|.|  ||...||:.||||:||..|.||....|:|:.|:||||||:.|||.||..
Mouse    88 ------PLVLQGPL--DCGSLLGFRAVYRMCFATAAFFFFFMLLMICVRSSRDPRAAIQNGFWFF 144

  Fly   143 KFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESAE--NSRG 205
            ||||..|..:||.:||||||.....:.|::|...|||:||::.||||||..:.|:..||  :|..
Mouse   145 KFLILVGITVGAFYIPDGSFPKIWFYFGVVGSFLFILIQLILFVDFAHSWNQRWLCKAEECDSPA 209

  Fly   206 YYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAVQERLPH 270
            :|..|...|.|.|:||:..:.|:::|:|.|..|...|.|||:||.||:.:|:|::||.||:..|:
Mouse   210 WYAGLFFFTFLFYLLSIAAVALMFVYYTESGACHEGKVFISLNLTFCVCVSIIAVLPKVQDAQPN 274

  Fly   271 SGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTHTTRVTFDTTNIIG 335
            |||||:|::||||:::||||::|.|:::|||.:     ...|.|.......::| |.:|..:|:|
Mouse   275 SGLLQASVITLYTMFVTWSALSNVPDQKCNPHL-----PTKNGTGQVDLEDYST-VWWDAPSIVG 333

  Fly   336 LVVWLLCILYNCISSAVEVSKISHDNSEKRE--ALSDTE------------AGTDGSGKPSTDTE 386
            ||:::||..:           ||..:|:.|:  :|..||            |.:||.   :.|.|
Mouse   334 LVIFILCTFF-----------ISLRSSDHRQVNSLMQTEECPAEMVQQQQVAVSDGR---AYDNE 384

  Fly   387 TEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSFGNRAVQRQRGFHVGQDRLQLAGCLH 451
            .:|||||:|.||...|.|||:|||||||||:                     .|:.|..::....
Mouse   385 QDGVTYSYSFFHFCLVLASLHVMMTLTNWYS---------------------PGETRKMISTWTS 428

  Fly   452 LWLEPCSA 459
            :|::.|::
Mouse   429 VWVKICAS 436

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	171/417 (41%)
Serinc2	XP_006503126.1	Serinc	25..457	CDD:367456	176/461 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849129
Domainoid	1	1.000	337	1.000	Domainoid score	I1110
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	351	1.000	Inparanoid score	I2254
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm43909
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.870