DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and Serinc5

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_766176.1	Gene:	Serinc5 / 218442	MGIID:	2444223	Length:	461	Species:	Mus musculus

Alignment Length:	440	Identity:	154/440 - (35%)
Similarity:	229/440 - (52%)	Gaps:	60/440 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 CSAAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTLK-KMPFC 71
            |.|.|.|.|||....|:||..||....:.::||||.|..::...|..:.::|.:...:| .:||
Mouse     5 CCAGQLACCCGSAGCSLCCGCCPKFRQSRTTRFMYLFYFILVIALCCVMMTPSVMKQVKDHIPF- 68

  Fly    72 INSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSRDPRSHIQ 136
                  :........:||..   ||..:||.|||||||||||||||..|:.|.|.:|:..|::|.
Mouse    69 ------FEEFCKKTQAGGDA---CENLVGYSAVYRVCFGMACFFALFCLLTLKVNNSKSCRAYIH 124

  Fly   137 NNFWPLKFLICFGAAIGAIFIPD-GSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAENWIESA 200
            |.||..|.|:......||.|||| .:|.....:||..|...||.:||::||.|||...:||....
Mouse   125 NGFWFFKLLLLGAMCSGAFFIPDQETFLKVWRYVGAGGSFLFICIQLLLIVQFAHKWNKNWTAGT 189

  Fly   201 ENSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISVISILPAVQ 265
            ..::.:|.:|:.|||:.|.:::.|:.|:.:::|....|..||..:.::...|:.||:::|.|.||
Mouse   190 VRNKLWYASLSLVTLIMYSVAVGGLALMAVFYTQWDDCMDNKILLGVHGGLCVLISLVAISPCVQ 254

  Fly   266 ERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPP------THTT 324
            .|.||||||||.|::.|..|||:||:.:.|||:       :::..|...|..||.      ....
Mouse   255 NRQPHSGLLQSGLISCYVTYLTFSALTSKPEKK-------VLDEHGKNVTICAPDFGQDLHRDEN 312

  Fly   325 RVTFDTTNIIGLVVWLLCILYNCISSAVEVSKISHDNSEKREALSDTEA-------GTDGSGKPS 382
            .||:     :|.::.::||.|:|::|   .::.|.|..:.|....:.|.       |.||.
Mouse   313 MVTW-----LGTLLLIVCISYSCLTS---TTRSSSDALQSRYGAPELEVARCCFCFGPDGE---- 365

  Fly   383 TDTETE---------------GVTYSWSMFHLVFVCASLYVMMTLTNWYN 417
             |||.:               |..||:|.||.||..||||||||||:|::
Mouse   366 -DTEEQQNVKKGPRVIYDEKKGTVYSYSYFHFVFFLASLYVMMTLTSWFH 414

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	150/430 (35%)
Serinc5	NP_766176.1	Serinc	13..458	CDD:281358	150/432 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849127
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.860