DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment TMS1 and SERINC3

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	NP_006802.1	Gene:	SERINC3 / 10955	HGNCID:	11699	Length:	473	Species:	Homo sapiens

Alignment Length:	454	Identity:	192/454 - (42%)
Similarity:	260/454 - (57%)	Gaps:	49/454 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAALGICSAAQCAMC-CGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDT 64
            |||.||:.|.|....| |.| |:.:.||.||:..|::.:|.:||||||:.||:..|.....::..
Human     1 MGAVLGVFSLASWVPCLCSG-ASCLLCSCCPNSKNSTVTRLIYAFILLLSTVVSYIMQRKEMETY 64

  Fly    65 LKKMP-FCINSTSSYSSGALSAVSGG--------SLQVDCEYALGYMAVYRVCFGMACFFALMSL 120
            |||:| ||               .||        :...||:..:||.||||:.|.||.||.:.||
Human    65 LKKIPGFC---------------EGGFKIHEADINADKDCDVLVGYKAVYRISFAMAIFFFVFSL 114

  Fly   121 IMLGVKSSRDPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVII 185
            :|..||:|:|.|:.:.|.||..|.....|..:|:.:||.|.|......||:||...|||:|||::
Human   115 LMFKVKTSKDLRAAVHNGFWFFKIAALIGIMVGSFYIPGGYFSSVWFVVGMIGAALFILIQLVLL 179

  Fly   186 VDFAHSLAENWIESAE--NSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISIN 248
            ||||||..|:|:...|  |.|.:|.||...|...||||:..:.|||.|:|...||..||||||||
Human   180 VDFAHSWNESWVNRMEEGNPRLWYAALLSFTSAFYILSIICVGLLYTYYTKPDGCTENKFFISIN 244

  Fly   249 LIFCLAISVISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGF--- 310
            ||.|:..|:|||.|.:||..|.||||||||:||||:||||||::|.|::.|||.:...:...
Human   245 LILCVVASIISIHPKIQEHQPRSGLLQSSLITLYTMYLTWSAMSNEPDRSCNPNLMSFITRITAP 309

  Fly   311 ----GNATTTAAPPTHTTR--VTFDTTNIIGLVVWLLCILYNCI--SSAVEVSKISHDNSEKREA 367
                ||:|.....||..::  ...|:.|.|||.|::||:||:.|  |:..:|.|::...|:. ..
Human   310 TLAPGNSTAVVPTPTPPSKSGSLLDSDNFIGLFVFVLCLLYSSIRTSTNSQVDKLTLSGSDS-VI 373

  Fly   368 LSDTEAG-----TDGSGKPSTDTETEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSF 426
            |.||...     .||..:.:.|.|.|||.||:|:|||:...||||:|||||:||:    |...|
Human   374 LGDTTTSGASDEEDGQPRRAVDNEKEGVQYSYSLFHLMLCLASLYIMMTLTSWYS----PDAKF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	182/428 (43%)
SERINC3	NP_006802.1	Serinc	16..471	CDD:308773	185/439 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158731
Domainoid	1	1.000	341	1.000	Domainoid score	I1084
eggNOG	1	0.900	-	-		E1_KOG2592
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	354	1.000	Inparanoid score	I2247
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm41859
orthoMCL	1	0.900	-	-		OOG6_101085
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1919
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800