DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment TMS1 and serinc2l

DIOPT Version :9

Sequence 1:	NP_001261947.1	Gene:	TMS1 / 39827	FlyBaseID:	FBgn0028399	Length:	467	Species:	Drosophila melanogaster
Sequence 2:	XP_009290780.1	Gene:	serinc2l / 100329297	ZFINID:	ZDB-GENE-100921-58	Length:	455	Species:	Danio rerio

Alignment Length:	466	Identity:	197/466 - (42%)
Similarity:	284/466 - (60%)	Gaps:	41/466 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAALGICSAAQCAMCCGGTAASMCCSACPSCTNASSSRFMYAFILLVGTVLGAIALSPGLQDTL 65
            |||.:.:||.|.||.|..|:|..:.|..|||..|::.:|.:::|.||:||::..|.:.||::..|
Zfish     1 MGACMALCSLASCASCLCGSAPCLLCGCCPSTNNSTITRLIFSFFLLLGTLVSVIMILPGMETQL 65

  Fly    66 KKMP-FCINSTSSYSSGALSAVSGGSLQVDCEYALGYMAVYRVCFGMACFFALMSLIMLGVKSSR 129
            :|:| ||...|:         :.|....|:|:..:||.:|||:||.|||||.|...||:.||||:
Zfish    66 RKIPGFCQGGTT---------IPGIENHVNCDVIVGYKSVYRMCFAMACFFFLFFAIMIRVKSSK 121

  Fly   130 DPRSHIQNNFWPLKFLICFGAAIGAIFIPDGSFGPAMMWVGLIGGLAFILVQLVIIVDFAHSLAE 194
            |||..:||.||..||||..|..:||.|||||:|.....:.|::|..||||:||::::|||||..|
Zfish   122 DPRGAVQNGFWFFKFLILVGITVGAFFIPDGTFHDVWFYFGIVGSFAFILIQLILLIDFAHSWNE 186

  Fly   195 NWIESAE--NSRGYYYALAGVTLLCYILSLTGITLLYIYFTTSTGCGINKFFISINLIFCLAISV 257
            .|:.:||  ||:.::..|...|:|.|.|:...|.|.|:|:|....|..:|||||.|||.|:.:||
Zfish   187 VWVRNAEEGNSKCWFSGLLFFTILYYALAFAAIVLFYLYYTKPDNCTEHKFFISFNLILCVIVSV 251

  Fly   258 ISILPAVQERLPHSGLLQSSLVTLYTVYLTWSAVANNPEKECNPGMFGMMEGFGNATTTAAPPTH 322
            :||||.||:..|.|||||||::||||:|:||||:.|||.:||||.:.|::   .|.:||.|.||.
Zfish   252 VSILPKVQDASPQSGLLQSSIITLYTMYVTWSAMTNNPNRECNPSLLGLV---SNISTTEAVPTS 313

  Fly   323 T--TRVTFDTTNIIGLVVWLLCILYNCI--SSAVEVSKISHDNSEKREALSDTEAGTDGSGKPST 383
            :  |...:|...|:|||::|.|..|..|  ||..:|:::. ...|.:..:...|.|.||. :...
Zfish   314 SPGTVQWWDAQGIVGLVIFLFCTFYASIRSSSNAQVNRLM-QTEEGKGGVGGEEVGEDGL-RRVV 376

  Fly   384 DTETEGVTYSWSMFHLVFVCASLYVMMTLTNWYNNFLFPQTSFGNRAVQRQRGFHVGQDRLQLAG 448
            |.|.:||||::|.||...:.||||:||||||||.    |.|:  .:|:|              :.
Zfish   377 DNEEDGVTYNYSFFHFHLLLASLYIMMTLTNWYK----PDTT--TQAMQ--------------ST 421

  Fly   449 CLHLWLEPCSA 459
            ...:|::.||:
Zfish   422 MPAVWVKICSS 432

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
TMS1	NP_001261947.1	Serinc	16..417	CDD:281358	181/407 (44%)
serinc2l	XP_009290780.1	Serinc	17..453	CDD:281358	188/450 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594691
Domainoid	1	1.000	358	1.000	Domainoid score	I924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	377	1.000	Inparanoid score	I2044
OMA	1	1.010	-	-		QHG53917
OrthoDB	1	1.010	-	-		D1276632at2759
OrthoFinder	1	1.000	-	-		FOG0000665
OrthoInspector	1	1.000	-	-		otm25272
orthoMCL	1	0.900	-	-		OOG6_101085
Panther	1	1.100	-	-	O	PTHR10383
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X262
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910