DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG44836 and NSUN7

DIOPT Version :9

Sequence 1:	NP_730167.2	Gene:	CG44836 / 39825	FlyBaseID:	FBgn0266099	Length:	833	Species:	Drosophila melanogaster
Sequence 2:	NP_078953.4	Gene:	NSUN7 / 79730	HGNCID:	25857	Length:	718	Species:	Homo sapiens

Alignment Length:	779	Identity:	171/779 - (21%)
Similarity:	312/779 - (40%)	Gaps:	187/779 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 DPLRITKI----VSPGVSPCGRRSRTLKYCHSTAVK-------IKLKAGARWTLPTIANAAKLLR 132
            ||..|:::    :|.|.|..|...:| .|..|..|.       |:::..|:..|....|  :.||
Human    15 DPEIISQLTSLPLSGGKSSAGVPEKT-GYPDSVYVMAANIFQGIRIEKSAQKVLIKYGN--EPLR 76

  Fly   133 KPPILVDFQNEHEMRLAFSLIYDVFRYKVVMSNALADVSFFEEHTELKNDEQRIWLMLFELYDRQ 197
            .   |.:.:::...||::.|.:...:|:.::...|.|...|...|...:....|.:||::..||:
Human    77 S---LSESEDQSFQRLSYELAFSALKYQDILETILIDSCIFPSTTIPDHLSSLIIVMLYDFQDRK 138

  Fly   198 FKGR--NSEEKDLQARLYKESEVTELADLLWQHRIRLAASISRMRIQVGALRLSQLLPIHLQNEK 260
            |:.|  :..|:.:       |||.|:.:||...:|:|||:::|.||:..||.:..:||..::.::
Human   139 FQTRVLSDNEEPI-------SEVQEVENLLNSFKIKLAAALARCRIKHDALSIYHILPETVRKQE 196

  Fly   261 VAIAAANPVVTGWINPFLVRNKEEADKILTGMGF----TVHGPDDEEPLLVQHCKWDNICPLVIS 321
              :.|:...:..|||...: :.||....|...|:    :|...||:...:.||| :|      :.
Human   197 --LRASTLPLYAWINTCKI-SPEEVYNNLKRRGYNKVKSVLHIDDKVFAVDQHC-YD------VL 251

  Fly   322 CIPKD-RSEFTKSVLMSKHYFIMQDKNFTFGPAIMSKLMDYFELDGDILQTHIGSPRSTAYLAAL 385
            ..|.. :::.....|...:..|.|||:.:.....:..|::   :|.|:|..:.||..:.::::.|
Human   252 IFPSHLKNDLINIDLFKDYKLIFQDKSRSLAVHSVKALLN---MDDDVLMVNTGSWYTVSHMSIL 313

  Fly   386 FYSINRVNNFYVYGAGANLK--EYRRYMESIGVNNIRLFGDAFTSFPMESNRFRTVVGIFATPPN 448
              :.|..:..:|.|..:..|  :.:.....||..||.:..:.|.:...:.:|.:.|..|...|..
Human   314 --TNNNTSKVFVCGVQSQAKDPDLKTLFTKIGCKNIEILHEKFINIESKDHRLQKVKVILLLPRC 376

  Fly   449 SFSAISDPIDLICSRGGDLSMLEVLTESEVSDEGRQRVAMILEEQLLTLTMSMSRPQVQFVLYQT 513
            |...:|:|::.|.:...|...|:..::..:|.:   ::.::.::|...||.:|...:.|.|:|.|
Human   377 SGLGVSNPVEFILNEHEDTEFLKDHSQGGISVD---KLHVLAQQQYEQLTHAMKFTKAQAVVYCT 438

  Fly   514 HSIVGTENEDMVQHVLELINKLALEKHRNAYKEQKRLEAIAEAEAANIPAAAMSKDSPRKKDKPS 578
            .|:...|||.:|:..||.                                    :|...|
Human   439 CSVFPEENEAVVKKALEF------------------------------------QDLGNK----- 462

  Fly   579 AQPEPPAPGPPGCTATPLPRVESIDLIVTPDIDEFVQDTVPDICINQDNCIKQQVTGSYLALVRR 643
              .:|....||   ..||..::.|.|    ..|:|.:....:|           ..|.:|:::.|
Human   463 --GQPYRLSPP---VLPLCSLKEIQL----STDKFFRMEPSEI-----------TNGCFLSILTR 507

  Fly   644 K----TLTHLNEKYLIRRAEQRGL-----FGKPEKDVKERSRPKTVKLQEQQSEPAPQDMGYDPR 699
            :    ....:|:  ::.||..:||     .||..|..|::.:.||     ..::.|..|.|..
Human   508 ERDPSETVSVND--VLARAAAKGLLDGIELGKSSKREKKKKKSKT-----SLTKGATTDNGIQ-- 563

  Fly   700 GSAHTSSAQQILQRLQRSTSASA-IRSHLTK------------VSSTYRRPIAF-------NFVR 744
                    .:|.:.|.|.|.||| :...:||            .||..|:|...       .||:
Human   564 --------MKIAEFLNRETKASANLSETVTKPPLPQKNTAQVGASSQTRKPNKLAPHPAVPAFVK 620

  Fly   745 RECK-------------------------RFYVLPVYM-HSTKQSI--RLWWQYAY-KCVTPSA 779
            ..|.                         :..:.||:| .|:.|.|  |:..|:.| :.|.|.|
Human   621 NTCPSRPRERQTHFLRPRPEDRMVALKPIKIVLPPVFMPFSSPQGIRSRMPTQHLYCRWVAPKA 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG44836	NP_730167.2	None
NSUN7	NP_078953.4	Methyltr_RsmF_N	131..509	CDD:330305	101/463 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..557		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..616		7/37 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	694..718
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148751
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0009874
OrthoInspector	1	1.000	-	-		oto89538
orthoMCL	1	0.900	-	-		OOG6_108177
Panther	1	1.100	-	-	LDO	PTHR14663
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.840