DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAF2 and PRR36

DIOPT Version :9

Sequence 1:	NP_001261943.1	Gene:	RAF2 / 39821	FlyBaseID:	FBgn0036624	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_001177396.1	Gene:	PRR36 / 80164	HGNCID:	26172	Length:	1346	Species:	Homo sapiens

Alignment Length:	944	Identity:	233/944 - (24%)
Similarity:	294/944 - (31%)	Gaps:	347/944 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 SKQRPQKTKSKGSESEKPGNGAPESA----AATEKNEKPDDDAVP----PSTR------------ 78
            |..|...|:|.|:.|..|.:..|.|.    |...||..|...:.|    .:||
Human    73 SAPRAGPTRSAGTSSRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRIS 137

  Fly    79 -SETIRRIRQLQ------LQRGRLPNLYFKRRSIRWLRPN----KMDYNSYFDGLKDLLPKRKLK 132
             .||:.|.:..:      |..|       .||......|.    .|...|...|.:..||:....
Human   138 AEETVARGKATEAPKRSALSAG-------ARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 195

  Fly   133 HLVRFHDRQRRTYDSRSISRSRSHSRSLSRSCSRSR-------SRSYSRSRSGSGSPELICLDDT 190
            ...|......|    :|:|.:..||.:.....:|.|       .|..|||.|.|.:
Human   196 ARPRPPTEGPR----KSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT--------- 247

  Fly   191 ENEDSPEKPEQEPARVTPIKENKPTLPA--------------PPQLNYELPERKKANPLGNNENG 241
                    |...|||..|.....|..||              |||:.   |.||.|.|.
Human   248 --------PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT---PPRKDAAPA------ 295

  Fly   242 ASILDEFLVKKDPQEPVFDYGKLSA---CRELEQALKDRSRDAPNEAESLVVDATLKRRRSVTPP 303
                               .|.||:   ........|.|....|:.| :..:.|||.....||||
Human   296 -------------------LGPLSSSPLATPSPSGTKARPVPPPDNA-ATPLPATLPPSPPVTPP 340

  Fly   304 ASEEKRNNEVEDDNIIGFSTVQQQKPMEAAPPLNLRMPTTPSTNPLQRQQAFKLSTPYTLAPPTA 368
            ..                :.:|.|     |||   .:|.||.::.|..|    |:||..||||:.
Human   341 PP----------------AALQSQ-----APP---TLPATPHSSSLTCQ----LATPLPLAPPSP 377

  Fly   369 AKQADTYSLNTPPPT------ATQMQISYPNEKLSNNMKANATFSIQQTALS--QVAASYAAAPQ 425
            :......:|.:||.|      .||:.:|:|...:|:...|....|:..:..|  |......|.|.
Human   378 SAPPSLQTLPSPPATPPSQVPPTQLIMSFPEAGVSSLATAAFVASVSPSVSSPLQSMPPTQANPA 442

  Fly   426 VAALAQRAPSQVAPLQQAPVQQMH----------------FPRSV------------PPQQLP-- 460
            :.:|    |:.::||...|:..|.                ||.:.            |||..|
Human   443 LPSL----PTLLSPLATPPLSAMSPLQGPVSPATSLGNSAFPLAALPQPGLSALTTPPPQASPSP 503

  Fly   461 -PPQQRAPPQQLATAPFAPPRHLA----QHRPS---------PQQLAPSQQLAPPHQLAPPHQLA 511
             ||..:|.|..|||.|......||    |..||         |..::||...:||.| ||||..|
Human   504 SPPSLQATPHTLATLPLQDSPLLATLPLQASPSPLTTVSLQDPPLVSPSLLASPPLQ-APPHPQA 567

  Fly   512 PPQQRAPPQQLAPPHQLAP----PHQLAPPQQRAPPQQLA------------------------- 547
            ||....||.|..|..|..|    ||.|..|..:|||..||
Human   568 PPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMS 632

  Fly   548 ---------------------PPQQ------LAPPQQ---------------------------- 557
                                 ||.|      .:||.|
Human   633 PRQTQASLISPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLASH 697

  Fly   558 -------------------LAPPQQLAPPQQLAPPQQRAPPQQRAPPQQLA------PPQQRAP- 596
                               ||||....||..|..|.....|....||.|.|      ||.:..|
Human   698 SPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPPLENLPS 762

  Fly   597 --------------TQHMAPPQHMAP-PQQLAPTQQLAPPPQQ----LAPRPQ---QLAPPPQQ- 638
                          |.|:..|...|| |.|..|:....|||:.    ..|.||   .||.||.|
Human   763 LAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQG 827

  Fly   639 --------LAPPPQQ----LAPPPQQPDSSRPASVQPLTPQRHASPHQLAQSQQVH--QSPSQLH 689
                    ||.||.|    ||.||.|...|.||| .||:|....|| |...:..||  |:|....
Human   828 LPSPPLSPLATPPPQAPPALALPPLQAPPSPPAS-PPLSPLATPSP-QAPNALAVHLLQAPFSPP 890

  Fly   690 PVPVAAPNFAVPQQPQPRRSETVSTQT-QGLGSP 722
            |.|.....|:.|..|....|.|..:|. ..|.:|
Human   891 PSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAP 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAF2	NP_001261943.1	zf-MYND	1078..1115	CDD:280009
PRR36	NP_001177396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..403		96/414 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	426..512		19/89 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	537..606		26/69 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	633..679		6/45 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	711..1155		69/216 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1168..1240
		DUF4596	1303..1346	CDD:292007
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CSWZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900