DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAF2 and Prr36

DIOPT Version :9

Sequence 1:	NP_001261943.1	Gene:	RAF2 / 39821	FlyBaseID:	FBgn0036624	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	XP_017168469.1	Gene:	Prr36 / 73072	MGIID:	3605626	Length:	1120	Species:	Mus musculus

Alignment Length:	818	Identity:	191/818 - (23%)
Similarity:	281/818 - (34%)	Gaps:	264/818 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SESEKPGNGAPESAAATEKNEKPDDD-AVP---PSTRSETIRRIRQLQLQRGRLPNLYFKRRSIR 106
            ::|..|.:||| |.|.|.::..|..: .:|   ||.|.      |.|..:..|.|.......|..
Mouse   220 ADSLGPTSGAP-SPAITRRSRAPATEVGLPQPAPSARQ------RPLTTEAARKPGSSASEPSAT 277

  Fly   107 WLRPNKMDYNSYFDGLKDLLPKRKLKHLVRFHDRQRRTYDSRSISRSRSHSRSLSRSCSRSRSRS 171
            .|.|                                 .:..||:: ..|..:.:|||...|.:..
Mouse   278 ELSP---------------------------------AFRRRSVA-GGSLQKPVSRSLIPSATPQ 308

  Fly   172 YSRSRSGSGSPELICLDDTENEDSPEKPEQ--EPARVTPIKENKPTL-----------PAPPQLN 223
            .|.||||. ||.:.............|.:|  .|.:.|..::|||::           |.||
Mouse   309 LSPSRSGV-SPRVTPRAPAHTSQLKSKGQQALHPTQTTVPRKNKPSVQSLIPASSLVTPTPP--- 369

  Fly   224 YELPERKKANPLGNNENGASILDEFLVKKDPQEPVFDYGKLSACRELEQALKDRSRDAPNEAESL 288
                             |||.:      :.|.:|                  .::...|:...:.
Mouse   370 -----------------GASSV------QGPDDP------------------SQTTLPPSPPTTP 393

  Fly   289 VVDATLKRRRSVTPPASEEKRNNEVEDDNIIGFSTVQQQKPMEAAPPLNLR-MPTTPSTNPLQRQ 352
            .:.|:|   :.:.|.||.:          .:..|...|..|  :.|||:|: :|:||:|.||
Mouse   394 PLPASL---QLLQPQASSQ----------AVPHSQSGQGSP--SPPPLSLQNLPSTPATPPL--- 440

  Fly   353 QAFKLSTPYTLAPPTAAKQADTYSLNTPPPTATQMQISYPNEKLSNNMKAN--ATFSIQQTALSQ 415
                      |||||:....:  :.::|||.|.   ||.....|..||..|  ::.::.|..||
Mouse   441 ----------LAPPTSLDTEE--ASDSPPPRAV---ISSSPPPLIQNMPPNQASSATLPQETLS- 489

  Fly   416 VAASYAAAPQVAALAQRAPSQVAPLQQAPVQQMHFPRS-VPPQQLP------------PPQQRAP 467
             |..::.||  .:||. :|.|:.|  ..|:...:.|.| |...|||            ||..||.
Mouse   490 -AMPFSPAP--LSLAS-SPPQLLP--SPPISPQNLPTSLVTSSQLPLSTPFRANFSESPPLPRAT 548

  Fly   468 PQQLATAPFAPPRHLAQHRPSPQQLAPSQQLAPPHQLAPPHQLAPPQQRAPPQQLAPPHQLA--- 529
            .....|.....|..||...|    ::.|..::||   .|...:..|..|.|..|..|..|.:
Mouse   549 LANRTTPSLQDPLFLAISPP----VSSSTSISPP---LPTSSVVTPPLRLPLSQTLPTSQASLLT 606

  Fly   530 -PPHQLAPPQQRAPP--------QQL---APPQQLAPPQQLAPPQQ---LAPPQQLAPP-----Q 574
             ||...:.||...||        .||   :|..|.:|.....||.|   |..|...|||     .
Mouse   607 LPPSLASSPQPATPPPLALSPLSTQLSTGSPSLQASPSFLPTPPMQPRALPSPSLQAPPVTYPLP 671

  Fly   575 QRAPPQQRAPPQQLAPP----------QQRAPTQHMAPPQHMAPPQQLAPT-QQLAPPPQQLAPR 628
            ..:||.....|..|:||          ...:|:..:|.|...|||...:|| ..||.||.|..|.
Mouse   672 LSSPPASPPLPALLSPPASPPLESPLSPSASPSSPLATPPPEAPPSLGSPTLSPLATPPPQTPPL 736

  Fly   629 ------------------PQ--QLAPPPQQLAPPPQQLAPPPQQPDSSRPASVQPLTPQRHASPH 673
                              ||  .||.||.|.:|.|..:..|...|..:.|:...|.:|...|:|.
Mouse   737 AFPPLPASTSSLDTATCFPQGPLLALPPLQTSPSPLTIPCPQTPPSLALPSLQSPSSPLATATPP 801

  Fly   674 ---QLAQSQQVHQSPSQL-----------------HPVPVAAPNFAVPQQ--------------- 703
               .|.....:...||.|                 .|.|.|:|....|::
Mouse   802 LQIPLVVLPTLQTPPSPLTTFPPGVPPGLTSPVVQPPSPPASPPLQAPRRPPTPGPDVPITGPRL 866

  Fly   704 ---------PQPRRSETVSTQTQGLGSPAASSSTTRQK 732
                     |.|.||.:.:.....|...::|:::|.::
Mouse   867 TLALAPAPPPPPSRSPSSTLSGPDLAGHSSSATSTPEE 904

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAF2	NP_001261943.1	zf-MYND	1078..1115	CDD:280009
Prr36	XP_017168469.1	PHA03247	<34..642	CDD:223021	130/554 (23%)
		PHA03247	<456..864	CDD:223021	111/424 (26%)
		DUF4596	1076..1120	CDD:373786
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2CSWZ
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900