DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RAF2 and pis-1

DIOPT Version :9

Sequence 1:	NP_001261943.1	Gene:	RAF2 / 39821	FlyBaseID:	FBgn0036624	Length:	1117	Species:	Drosophila melanogaster
Sequence 2:	NP_501748.1	Gene:	pis-1 / 177818	WormBaseID:	WBGene00004031	Length:	1076	Species:	Caenorhabditis elegans

Alignment Length:	965	Identity:	203/965 - (21%)
Similarity:	319/965 - (33%)	Gaps:	316/965 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   232 ANPLGNNENGASILDEFLVKKDPQEPVFDYGKLSACRELEQALKDRSRDAPNEAESLVVDATLKR 296
            |:||...|:         ::..|..|..             .|.|.||
Worm     2 ADPLSKEED---------IQHRPDSPPL-------------GLLDPSR----------------- 27

  Fly   297 RRSVTPPASEEKRNNEVEDDNIIGFSTVQQQKPMEAAPPLN-LRMPT--------------TPST 346
               :..|.:.::.:...:..|..||  |..::|.:..||.. .|.||              ||.:
Worm    28 ---IQNPLANDQLHQVPQQQNPSGF--VMPEQPRQQPPPQTWQRTPTMSPANIFQGDSGSGTPGS 87

  Fly   347 -------------NPLQRQQ---------AFKLSTPYTLAPPTAAKQADTYSLNTP-----PPTA 384
                         ||.|.||         |....||.|  |.:|.....  :..||     |||:
Worm    88 QRSSTGTPNHQMGNPPQHQQQQFFHGESPAHSQGTPMT--PQSAGMPGS--NCGTPQSAGGPPTS 148

  Fly   385 TQMQISYPNEKLSNNMKANATFSIQQTALSQVAASYAAAPQVAALAQRA----PSQV--APLQQA 443
                :.|..::        |....||.|.:..||:.|...|...|.|:.    |.|:  :|.:|.
Worm   149 ----VPYDYQQ--------AQMQQQQHAQAMAAAAAAQQQQQQHLQQQQYAQNPQQMHDSPYRQH 201

  Fly   444 PVQQMHFPRSVPPQQLPP--PQQRAPPQQLATAPFAPPRHLAQHRPSPQQLAPSQQLAPPHQLAP 506
            .:.||| .....|.|.||  |||:|...|                   ||:...|..|.....|.
Worm   202 QMMQMH-QHPGHPSQYPPGYPQQQAAQWQ-------------------QQMYARQAAAQAQAQAQ 246

  Fly   507 PHQLAPPQQRAPPQQLAPPHQLAPPHQLAPPQQRAPPQQLAPPQQLAPPQQLAPPQQLAPPQQLA 571
            ....|..||||..|::..|:   ||... ||....|.....|.|..|.|:  ..|....|  ...
Worm   247 AQAQAQAQQRAAAQRVPVPY---PPGAY-PPGMPGPMTPGYPAQAPAAPR--TTPGSAGP--GTG 303

  Fly   572 PPQQRAPPQQRAPPQQLAPPQQRA-----PTQHMAP-------------PQHMAPPQQLAPTQQL 618
            ||   ..||:...||...|..|:|     |||.|.|             |...:|..|:....|.
Worm   304 PP---GTPQRPQYPQGTNPQPQQAQFTYPPTQQMTPTGQPPGYPGMPGTPTFSSPAHQMFRQGQP 365

  Fly   619 APPP---QQLAPRPQQLAPPPQQLAPPPQQLAPPPQQPDSSRP--ASVQPLTPQRHASPHQLAQS 678
            ..||   |.::|:..|..|.|    ..|.:.|||.....:|.|  |...|....|  ||..::.:
Worm   366 TAPPGMRQYISPQAGQQQPTP----GTPHRFAPPGPSGTTSSPHFAPGAPGADLR--SPSLMSPN 424

  Fly   679 QQVHQS----PSQLH---------PVPVAAPNFAVPQQPQPRRSETVSTQTQGLGSPAASSSTTR 730
            ||..|.    |..||         |:       |:|.||.|        ||||...|..|:|:..
Worm   425 QQSQQHTPVLPRSLHNEMTSHGMRPI-------ALPSQPLP--------QTQGTPQPILSASSLP 474

  Fly   731 QKSFVDLNNSDANFHYRVKE-----LFDELNSTMIDKINSVP------PD--------------- 769
            .:|     .....|.||.::     ..:::|. |...:|..|      |:
Worm   475 PQS-----AGATQFVYRPQQPNQMNTMNQMNQ-MHHDVNPFPIQMNVDPELYLTGIHFHCFDSEK 533

  Fly   770 --EDSL-KKERERIV----ADLAALDKLMAQKEDEYNRLLYLSCIKKELHERMERKERLIRIKDL 827
              ||.| :|..|.::    .|:........::..:...:|..||....:...:|.::|::.|:.:
Worm   534 LFEDKLDRKNLEFMIKYHGGDIEFEASKFHERIHQITHVLVDSCRNTNVMTSLEHRKRIVSIQWI 598

  Fly   828 LPILINKCGTKELSEVKAMLEEEIDSPMASKH-----------SLSAIEKLLNYAELNQNIIQLL 881
            :.:               |..|.::.|....|           .|..:..|..:....:..|..:
Worm   599 IDV---------------MERERVELPWRIAHLPPPFNENFRPYLGKLFSLSGFDSSERAAISFM 648

  Fly   882 RGSLGLNKRAPSVSPANFEDDQMLFRRDS----------LPVSHLSMRDQHYESRNAVNDHLLDS 936
            ...:|. |..|.::..|   |.::.::.:          :||.:.......|     |.|   ::
Worm   649 AEMMGA-KITPFLARQN---DLLIAKQPADKVTRAQEWKVPVVNFQWIADAY-----VCD---EA 701

  Fly   937 NPDRDPPAKRPKLIHSQDSNQDMASSSTHLSANLSETLRKIRAWKNYSHFSNVSME--------- 992
            :|.:.|..:.|:.........::.:|..|:.....|....:..||:.:..::.:.|
Worm   702 SPQKRPNVENPRYQLENPVMTNVNTSPNHIEGASQEFGAMMSCWKSQTIIADQAYEKARQNRKTL 766

  Fly   993 DNN---------SD-----NESQIEPLFNSSPMASRRQLANRQSYQEQHSANIND 1033
            .||         ||     .|.:|:        :||.:|...:::.|:|...:.|
Worm   767 QNNTFFFPSKRLSDQAVAPTEDEIK--------SSRARLDEIKTHWEEHQEKMKD 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RAF2	NP_001261943.1	zf-MYND	1078..1115	CDD:280009
pis-1	NP_501748.1	BRCT	517..602	CDD:278934	13/99 (13%)
		BRCT	615..694	CDD:278934	11/82 (13%)
		BRCT	834..899	CDD:237994
		BRCT	935..1015	CDD:214602
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28763
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010