DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Agpat3 and Lpcat2b

DIOPT Version :9

Sequence 1:	NP_001246793.1	Gene:	Agpat3 / 39820	FlyBaseID:	FBgn0036623	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_081875.1	Gene:	Lpcat2b / 70902	MGIID:	1918152	Length:	516	Species:	Mus musculus

Alignment Length:	394	Identity:	68/394 - (17%)
Similarity:	128/394 - (32%)	Gaps:	152/394 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KNSFVIKMGSLEKLKQLRLIHLCIALTFFTSGLCIN---FIQLLMHVF-----IKPIDKRLFRKL 61
            :|..:.::.|..|..|:.:         |..|||.|   .:...:..|     ::|:..|....|
Mouse   195 RNEILRRVKSKMKWPQILI---------FPEGLCTNRSCLVTFKLGAFSPGVPVQPVLLRYPNSL 250

  Fly    62 -----------MYYACYSLYSQLI------FVSDWYAGSKMTVYMDKEDFEK------------- 96
                       .:..|....|||.      |         |.||:..|:.:|
Mouse   251 DTVTWTWNGFSGFQVCMLTLSQLFTRVEVEF---------MPVYIPSEEEKKDPILFANTVRIKM 306

  Fly    97 ----------HAGKEHVLLI------------------MNHKYEIDWLN---------GWMICEK 124
                      |:.::..|:|                  ::.|.::||.|         .:.:..|
Mouse   307 ANALKLPVTDHSLEDCKLMISAGALQLPMEAGLVEFTKISQKLKLDWDNIHKHLDQYASFAVSSK 371

  Fly   125 LGVLGNCKAYAKKAIRYVPIIGWGWWLAEFVFLNRNFDQDKTIITEQLKVVFSYPDPTWLLLNAE 189
            .|.:| .:|::    ||:                      |..|:|.|:.:||..|     .|.:
Mouse   372 GGKIG-IEAFS----RYL----------------------KLPISEPLRQLFSLFD-----RNQD 404

  Fly   190 GTRFTPAKHEASVKFAQ-ERGMTVLKHHLIPRTKGFTASLAPIRGLCPVIYDINLAYRPTDKTPA 253
            ||          :.|.: ..|:|||.:         .::...|..:...::|::.....|::...
Mouse   405 GT----------IDFREYVIGLTVLCN---------PSNTEKILQMSFKLFDLDEDGYVTERELT 450

  Fly   254 TMLSLLHGKSVEPHLLMRRIPLEQVPEDEKEAAAWLQNLFVEKD----KIIDSFLETGSFFKTSG 314
            |||....|   .|.|.:..:..:...:|..:.:......|..|.    |:..|:::..:.:..|.
Mouse   451 TMLQAAFG---VPDLDVSTLFQQMAGKDSDQVSYRTFRRFALKHPAYAKLFHSYIDLQAAYIYSL 512

  Fly   315 IKEV 318
            .:||
Mouse   513 PREV 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Agpat3	NP_001246793.1	PLN02380	23..387	CDD:178006	64/376 (17%)
		LPLAT_LCLAT1-like	75..271	CDD:153252	43/246 (17%)
		Acyltransf_C	258..336	CDD:292694	11/65 (17%)
Lpcat2b	NP_081875.1	PlsC	65..307	CDD:223282	23/129 (18%)
		LPLAT_LPCAT1-like	111..323	CDD:153253	24/145 (17%)
		HXXXXD motif	142..147
		EFh	392..454	CDD:238008	17/85 (20%)
		EF-hand_7	392..453	CDD:290234	16/84 (19%)
		EFh	429..487	CDD:298682	9/60 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900