DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Agpat4 and YDR018C

DIOPT Version :9

Sequence 1:	NP_001261942.1	Gene:	Agpat4 / 39819	FlyBaseID:	FBgn0036622	Length:	380	Species:	Drosophila melanogaster
Sequence 2:	NP_010301.1	Gene:	YDR018C / 851581	SGDID:	S000002425	Length:	396	Species:	Saccharomyces cerevisiae

Alignment Length:	383	Identity:	90/383 - (23%)
Similarity:	162/383 - (42%)	Gaps:	75/383 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LRGLGRLLIAVTFFTCGFFVNIGQLLLILLVRPFDKKLSRSLAYYLHYSFYCILVCVAEWYAGSK 68
            ::||.|||||..|.:....:.:.|:.|.:|: |:.|...::.......:|..:|..:....|.|.
Yeast    21 IKGLQRLLIACLFISGSLSIVVFQICLQVLL-PWSKIRFQNGINQSKKAFIVLLCMILNMVAPSS 84

  Fly    69 LRVYIDPQDEQK--------FFGKEHGLLLMNHTYEIDWLTAWMITDKLGNLGGTKAY--AKKML 123
            |.|..:.....|        |..|:..:::.||....||:..|.:: .:.|||| ..|  .||.|
Yeast    85 LNVTFETSRPLKNSSNAKPCFRFKDRAIIIANHQMYADWIYLWWLS-FVSNLGG-NVYIILKKAL 147

  Fly   124 RYVPVLGWVWWMAEFIFLDRNFEKDKVVIKTQL------------------------KEVFSYPD 164
            :|:|:||:.....:||||.||::||:..:...|                        :.:.:|.
Yeast   148 QYIPLLGFGMRNFKFIFLSRNWQKDEKALTNSLVSMDLNARCKGPLTNYKSCYSKTNESIAAYN- 211

  Fly   165 PVWLLLNAEGTRFTPAKHELSVKFAEERGLP--LLKHHLIPRTKGFTTSLPTMRGICPAIYDINL 227
               |::..|||..:....|.|..|.:...|.  .|:|.|:|.:||...::..:.....||||:.:
Yeast   212 ---LIMFPEGTNLSLKTREKSEAFCQRAHLDHVQLRHLLLPHSKGLKFAVEKLAPSLDAIYDVTI 273

  Fly   228 AFKKNAEPKPTMLSQLNGE-------------PVEPYMYIRRVPLDVVP-DDEKEAAAWMQDFFA 278
            .:      .|.:.::..|.             |.:...|||...::.:| .|::....|:...:.
Yeast   274 GY------SPALRTEYVGTKFTLKKIFLMGVYPEKVDFYIREFRVNEIPLQDDEVFFNWLLGVWK 332

  Fly   279 EKDKIIDSFHETGSFFKNSGVKEVPEKIYKPRLST----------LLNFLGWATFAVL 326
            |||::::.::.||.|  .|..|...:.|.....:|          :|::.|:..|.:|
Yeast   333 EKDQLLEDYYNTGQF--KSNAKNDNQSIVVTTQTTGFQHETLTPRILSYYGFFAFLIL 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Agpat4	NP_001261942.1	PLN02380	12..366	CDD:178006	85/375 (23%)
		LPLAT_LCLAT1-like	58..255	CDD:153252	56/245 (23%)
		Acyltransf_C	243..320	CDD:292694	19/100 (19%)
YDR018C	NP_010301.1	LPLAT_LCLAT1-like	102..308	CDD:153252	51/217 (24%)
YDR018C	NP_010301.1	Acyltransf_C	300..>347	CDD:406475	12/46 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157345790
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0204
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	93	1.000	Inparanoid score	I1515
Isobase	1	0.950	-	0	Normalized mean entropy	S3011
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9217
orthoMCL	1	0.900	-	-		OOG6_102498
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3473
SonicParanoid	1	1.000	-	-		X1337
TreeFam	0	0.000	Not matched by this tool.
	10	9.670