DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment roq and rc3h1a

DIOPT Version :9

Sequence 1:	NP_001261940.1	Gene:	roq / 39818	FlyBaseID:	FBgn0036621	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001076328.2	Gene:	rc3h1a / 568568	ZFINID:	ZDB-GENE-050208-702	Length:	1078	Species:	Danio rerio

Alignment Length:	760	Identity:	364/760 - (47%)
Similarity:	450/760 - (59%)	Gaps:	109/760 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIQAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYNRQCPFDQTVIVSDIDNLP 65
            ||:|||.||:||.||||...|..:.|.|:|||||||:||:||..|:.:.||||||.|.:||:.||
Zfish     1 MPVQAPQWTEFLLCPICTQTFEENHRKPISLGCGHTVCKMCLNKLHRKACPFDQTTISTDIEQLP 65

  Fly    66 INHALLQLVKDSELLELAPPPPSVQKLEPEHLKCYQLGQRCIEELALHLKSFLNLNGNG------ 124
            :|.||||||..    ::...||.......|.:|.|:..:.|:|:|||:||...|..|.|
Zfish    66 VNTALLQLVSG----QVPKAPPVTLLTAAEDVKHYEESRTCVEDLALYLKPLSNTRGAGLNGAAQ 126

  Fly   125 NLLTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWAAVRTRG 189
            ::|:|||.|||||||:|||:|||||:||:|||||||||||||||||||||||||||||||||.||
Zfish   127 SVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARG 191

  Fly   190 CQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLYRASCFK 254
            |||||||||||.|||||||||:||||||||||:||||||||:|||||||||||||||||||||||
Zfish   192 CQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFK 256

  Fly   255 VSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKSHMQSII 319
            |:||:.||||||||||||||:|||||||:||||||.|.||||||:|||||||||..|||||||||
Zfish   257 VTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEGGLRIAPDQWSSLLYGDQSHKSHMQSII 321

  Fly   320 DKLQTPSSFAQSVQELVIALQRTSDPAKLSSLHHHLKYLANIDPCAEV-AP-WSVLAEALDAVRH 382
            ||||||:|||||||||.||||||.|||.|:.|..||:.||:|||..:. || |..||:.|:|||.
Zfish   322 DKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELLADIDPSPDAPAPTWEQLAKGLEAVRT 386

  Fly   383 SVVGLVNFLQHHGVRKAQDGISGGGSGGTTNSNPKYKISLCRDLNVRRVCPRGSSCTFAHSQEEV 447
            .|.|||:|:|:|..:        ||.......:.|||..:|||:..:..||||:||||||||:|:
Zfish   387 VVHGLVDFIQNHSKK--------GGDQQQPPQHSKYKTYMCRDMKQKGGCPRGASCTFAHSQDEL 443

  Fly   448 ERYRARNRGKHMKTPLALQGPPAVGVGAIKKPLGEQEGPPLGNMP--------PMLPMSPMHYMG 504
            |:||..|:...|:..|:   .....:..:...|...:|||:..:|        .:|...|    |
Zfish   444 EKYRKMNKRVGMRRQLS---QSLTQLNELDLGLLSDDGPPMEGLPRKSSSITNGILAAGP----G 501

  Fly   505 SPRGYL-----DPSL-----------GLSPGGGLPPSHHSPITRLIVPSRYDSRFSGFG------ 547
            |...:|     |||.           |.....|.||.....|.:..:.....||.:|.|
Zfish   502 SALAHLVSRGSDPSYEPTHKPTKMDSGSLSAPGSPPDSLESIPKSSMLMNAQSRIAGDGAVGQKH 566

  Fly   548 -GGTPRIPSP-REYQANPVAPTQRNANPPNFSVNSNL-----------HKGYMLPASGGDVFHLA 599
             ...||:|.. ..:|.:...|..|...||:.|..|:.           |:....||....:....
Zfish   567 LSAVPRVPQMYSSHQPDLYFPETRAPPPPSASYESSQYATAGNPYPHHHRYPRHPAPDPGMSPYP 631

  Fly   600 NPWEQAYLAQQQH-------------------PPQHPQQQQPPSS--KPNPSRPLSILPATADTS 643
            :.:...|:::.|:                   |..|||...|...  :.:|..|..:.|....||
Zfish   632 DSYPNPYVSKHQYANPSAHYGYPSRHDNRCHSPYAHPQTFAPREELVRRSPDIPPPLQPQNTSTS 696

  Fly   644 FFEKKPPNSVSIDLDRVPEVNVDAVPLFRRSNNNHNNNNSNSHNN 688
            :               :||   .|...:.....||.:...|.|.|
Zfish   697 Y---------------LPE---SAQERYTNDTYNHPSQIRNYHRN 723

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
roq	NP_001261940.1	zf-RING_5	13..55	CDD:291308	23/41 (56%)
roq	NP_001261940.1	zf-CCCH	418..444	CDD:279036	15/25 (60%)
rc3h1a	NP_001076328.2	RING	14..52	CDD:214546	20/37 (54%)
rc3h1a	NP_001076328.2	zf-CCCH	414..440	CDD:279036	15/25 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592148
Domainoid	1	1.000	103	1.000	Domainoid score	I6720
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I930
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004107
OrthoInspector	1	1.000	-	-		otm25783
orthoMCL	1	0.900	-	-		OOG6_105901
Panther	1	1.100	-	-	O	PTHR13139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3350
SonicParanoid	1	1.000	-	-		X2848
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.880