DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment roq and rc3h2

DIOPT Version :9

Sequence 1:	NP_001261940.1	Gene:	roq / 39818	FlyBaseID:	FBgn0036621	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	XP_017213498.1	Gene:	rc3h2 / 559834	ZFINID:	ZDB-GENE-060503-694	Length:	1028	Species:	Danio rerio

Alignment Length:	992	Identity:	398/992 - (40%)
Similarity:	516/992 - (52%)	Gaps:	236/992 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIQAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYNRQCPFDQTVIVSDIDNLP 65
            ||:||..||:||:||||.|||.|....|:||||.||:||.||..|:.:.||||||.|.:|||.||
Zfish     1 MPVQAAQWTEFLSCPICYNEFDACSHKPISLGCSHTVCKTCLHKLHRKACPFDQTAISTDIDVLP 65

  Fly    66 INHALLQLVKDSELLELAPPPPS--VQKLEPEHLKCYQLGQRCIEELALHLKSFLN----LNGNG 124
            :|.||||||.       .|.|..  |.....|..:.|::.:.|:|||||:||....    ::.:.
Zfish    66 VNCALLQLVG-------VPVPEGEVVSVGNAEDTRHYEVCRMCVEELALYLKPVSGGKGVMSASS 123

  Fly   125 NLLTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWAAVRTRG 189
            :.|:|||.|||||||||||:||||||||:||.||||||||||||||||||||||:|||||||.||
Zfish   124 SALSRPMQRKLVTLVNCQLVEEEGRVRAVRACRSLGERTVTELILQHQNPQQLSANLWAAVRARG 188

  Fly   190 CQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLYRASCFK 254
            ||||||||||:.|||||||||:||||||||||:||||:||.:|||||||||||||||||||||||
Zfish   189 CQFLGPAMQEDALKLVLLALEDGSALSRKVLVLFVVQKLEARFPQASKTSIGHVVQLLYRASCFK 253

  Fly   255 VSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKSHMQSII 319
            |:||:.||||||||||||||:|||||||||||.||.||||||:|||||||||||:.|||||||||
Zfish   254 VTKRDEDSSLMQLKEEFRTYEALRREHDAQIVHIAMEAGLRISPEQWSSLLYGDLTHKSHMQSII 318

  Fly   320 DKLQTPSSFAQSVQELVIALQRTSDPAKLSSLHHHLKYLANID--PCAEVAPWSVLAEALDAVRH 382
            ||||:|.|||:|||||.|.||||.|||.|:||...|:.||.||  |.|....|..|...|.||:.
Zfish   319 DKLQSPESFAKSVQELTIILQRTGDPANLNSLRAPLELLAGIDHNPDAAAPSWPELESVLLAVKV 383

  Fly   383 SVVGLVNFLQHHGVRKAQDGISGGGSGGTTNSNPKYKISLCRDLNVRRVCPRGSSCTFAHSQEEV 447
            .|.|||.|:|:.. :|:.:       ......|.|||.|:||||..:..||||:||||||:|||:
Zfish   384 VVHGLVEFIQNFS-KKSNE-------SPQAQPNSKYKTSMCRDLRQQGGCPRGASCTFAHTQEEL 440

  Fly   448 ERYRARNR------GKHMKTPLAL-----QGPPAVGVGAIK---KPLGEQEGP----PLG---NM 491
            |::|.|||      ...:..|..:     :....||.|.||   |...|...|    |.|   ..
Zfish   441 EKHRMRNRKASGAVRPFLSVPAVMAKSCTKAGSEVGPGGIKNHEKDASEDVSPTQLIPRGGDQQE 505

  Fly   492 PPML--PMSPMHYMGSPRGYLDPSLGLSPGGGLPPSH-HSP-ITRLIVPSRYDSRFSGFGGGTPR 552
            ..||  .::.:|...     |:.:||         || .|| |:.::...|:         |..:
Zfish   506 DKMLLSGVNGLHVTS-----LEQNLG---------SHSQSPSISSVMSTDRH---------GHVQ 547

  Fly   553 IPSPREYQANPVAPTQRNANP----------PNFSVNSNLHKGYMLPASGGDVF----------- 596
            :.:..||.:....|.:....|          |.|..:||:.:. |||.|.|.|:
Zfish   548 MRAHPEYCSQDQRPYELTPYPQSTIPPKSCSPRFHRSSNVPES-MLPPSVGPVYPDQHPSVPALD 611

  Fly   597 -----HLANPWEQAYLAQQQHPPQHPQQQ--QPP-----SSKPNPSRPLSILPATADTSFFEKKP 649
                 |...|  .||.:...:.|.:..::  :||     ..:.| |.||.:..:|.      .:|
Zfish   612 RLGPSHFGPP--SAYSSHGMYTPVYDSRRVWRPPLYPRDGGRSN-SLPLEVFRSTV------YQP 667

  Fly   650 P-----NSVS----------IDLDRVPEVNVDAVPLFRRSNNNHNNNNSNSHNNNN--------N 691
            |     ||:.          ..:.|.....||.:...::.:..|:::|.|..:.::        .
Zfish   668 PLRERYNSLDSPYCSTTEQRATMHRDAYTRVDELYRHKQEHWVHHHSNVNRASQSSPVFTVDMCP 732

  Fly   692 NH-----GSSLLFWNNTGKDS-ANFV--RSDSILDDDASTFDVPTGS---------------SML 733
            .|     |..:....:.|::| |::.  ...:|...::....:||.|               .:|
Zfish   733 EHPEGVGGGRMTCKCHGGEESLAHYSPWSCSTISPFESEPHHLPTHSCSKHLEEESGGKRWLHVL 797

  Fly   734 SIY--------------GPICPK------SSTTG---------------------NWNNF----- 752
            ..|              |||..|      :|.||                     |:.::
Zfish   798 EPYRRLKEEDPIIPFGEGPIISKWGAISRASRTGFHTTDPVQATASQGCTGTTSINFRDYGCHIG 862

  Fly   753 --DLGYGGFKSD--------------------RNDSFNANKQQQPMWGRKPQLMSEDSFEGGIDS 795
              ||.:|...||                    |..||::..:|      ...||.:|..|...|.
Zfish   863 HSDLRWGPRSSDSSTHSSFLESDHLAVSGLHARRTSFSSGTKQ------GLDLMGKDETENETDR 921

  Fly   796 GMMLQLEKNLVDIVDPD 812
            .  ::||.:.:||.|.:
Zfish   922 D--IELELSALDIEDTE 936

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
roq	NP_001261940.1	zf-RING_5	13..55	CDD:291308	24/41 (59%)
roq	NP_001261940.1	zf-CCCH	418..444	CDD:279036	17/25 (68%)
rc3h2	XP_017213498.1	zf-RING_5	14..55	CDD:291308	24/40 (60%)
rc3h2	XP_017213498.1	zf-CCCH	411..435	CDD:279036	15/23 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592149
Domainoid	1	1.000	357	1.000	Domainoid score	I936
eggNOG	1	0.900	-	-		E1_KOG3161
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	597	1.000	Inparanoid score	I930
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004107
OrthoInspector	1	1.000	-	-		otm25783
orthoMCL	1	0.900	-	-		OOG6_105901
Panther	1	1.100	-	-	LDO	PTHR13139
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750