DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment roq and RC3H2

DIOPT Version :9

Sequence 1:	NP_001261940.1	Gene:	roq / 39818	FlyBaseID:	FBgn0036621	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001094058.1	Gene:	RC3H2 / 54542	HGNCID:	21461	Length:	1191	Species:	Homo sapiens

Alignment Length:	950	Identity:	391/950 - (41%)
Similarity:	490/950 - (51%)	Gaps:	238/950 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIQAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYNRQCPFDQTVIVSDIDNLP 65
            ||:||..||:||:||||.|||..:...|:||||.||:||.||..|:.:.||||||.|.:|||.||
Human     1 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTDIDVLP 65

  Fly    66 INHALLQLVKDSELLELAPPPPSVQKLEPEHL---KCYQLGQRCIEELALHLKSFLNLNG----N 123
            :|.||||||        ....|..|.::..:|   |.|::.::|:|:|||:||......|    |
Human    66 VNFALLQLV--------GAQVPDHQSIKLSNLGENKHYEVAKKCVEDLALYLKPLSGGKGVASLN 122

  Fly   124 GNLLTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWAAVRTR 188
            .:.|:|||.|||||||||||:||||||||:|||||||||||||||||||||||||:|||||||.|
Human   123 QSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLSANLWAAVRAR 187

  Fly   189 GCQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLYRASCF 253
            ||||||||||||.|||||||||:||||||||||:||||||||:||||||||||||||||||||||
Human   188 GCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCF 252

  Fly   254 KVSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKSHMQSI 318
            ||:||:.||||||||||||:|:|||||||||||.||.||||||:|||||||||||:.||||||||
Human   253 KVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWSSLLYGDLAHKSHMQSI 317

  Fly   319 IDKLQTPSSFAQSVQELVIALQRTSDPAKLSSLHHHLKYLANIDPCAE-VAP-WSVLAEALDAVR 381
            |||||:|.|||:|||||.|.||||.|||.|:.|..||:.||||||..: |:| |..|..|:.||:
Human   318 IDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELLANIDPNPDAVSPTWEQLENAMVAVK 382

  Fly   382 HSVVGLVNFLQHHGVRKAQDGISGGGSGGTTNSNPKYKISLCRDLNVRRVCPRGSSCTFAHSQEE 446
            ..|.|||:|:|::. ||       |........|.|||.|:||||..:..||||::|||||||||
Human   383 TVVHGLVDFIQNYS-RK-------GHETPQPQPNSKYKTSMCRDLRQQGGCPRGTNCTFAHSQEE 439

  Fly   447 VERYRARNR--------------------------------------GKHM-------------- 459
            :|:||.||:                                      ||.:
Human   440 LEKYRLRNKKINATVRTFPLLNKVGVNNTVTTTAGNVISVIGSTETTGKIVPSTNGISNAENSVS 504

  Fly   460 --------KTPLALQGPPAVG-VGA-------------IKKPLGEQEGPPLGNM----------- 491
                    .|..||:....|| |||             .:..:|.....|:.|:
Human   505 QLISRSTDSTLRALETVKKVGKVGANGQNAAGPSADSVTENKIGSPPKTPVSNVAATSAGPSNVG 569

  Fly   492 ----------PPML---PMSPMH-----YMGSPR-------------GYLDP----SLGLSP--- 518
                      .|.|   |:.|.|     |...||             ||..|    ..|::|
Human   570 TELNSVPQKSSPFLTRVPVYPPHSENIQYFQDPRTQIPFEVPQYPQTGYYPPPPTVPAGVAPCVP 634

  Fly   519 ----GGGLPPSHHSPITRLIVPSRYDSRFSGFGGGTPR---------IPSPREYQANPVAP---- 566
                ...:|.|...|.:   :|  |...:|.|   :||         .|.|:.|...|..|
Human   635 RFVRSNNVPESSLPPAS---MP--YADHYSTF---SPRDRMNSSPYQPPPPQPYGPVPPVPSGMY 691

  Fly   567 -----TQRNANPPNFSVNSNLHKGYMLPASGGDVFHLA----------NPWEQAYLAQQQHPPQH 616
                 ::|...||.:..:..:....:.|.   ||.|.:          |..:..|....| ||..
Human   692 APVYDSRRIWRPPMYQRDDIIRSNSLPPM---DVMHSSVYQTSLRERYNSLDGYYSVACQ-PPSE 752

  Fly   617 PQQQQPPSSKPNPSRPLSILPATADTSFFEKKPPNSVSIDLDRVPEVNVDAVPLFRRS------- 674
            |:     ::.|.|..|...|..:.:.. ..:||.........:.|.|: ..:|:..:|
Human   753 PR-----TTVPLPREPCGHLKTSCEEQ-IRRKPDQWAQYHTQKAPLVS-STLPVATQSPTPPSPL 810

  Fly   675 ---NNNHNNNNSNSHNNNNNNHGSSLLFWN-NTGKDSANFVRS---DSILDDDASTFDVPTGSSM 732
               :...:.:.|.|......:|.|....|: .|.....|.:.|   |.|.:.:|...|:.:|...
Human   811 FSVDFRADFSESVSGTKFEEDHLSHYSPWSCGTIGSCINAIDSEPKDVIANSNAVLMDLDSGDVK 875

  Fly   733 LSIY-------------------GPICPK------SSTTG 747
            ..::                   |||..|      ||.||
Human   876 RRVHLFETQRRTKEEDPIIPFSDGPIISKWGAISRSSRTG 915

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
roq	NP_001261940.1	zf-RING_5	13..55	CDD:291308	23/41 (56%)
roq	NP_001261940.1	zf-CCCH	418..444	CDD:279036	16/25 (64%)
RC3H2	NP_001094058.1	zf-RING_5	14..55	CDD:291308	23/40 (58%)
		HEPN-N. /evidence=ECO:0000269\|PubMed:26489670	91..170		50/78 (64%)
		ROQ. /evidence=ECO:0000269\|PubMed:26249698	171..325		136/153 (89%)
		HEPN-C. /evidence=ECO:0000269\|PubMed:26489670	326..396		39/69 (57%)
		zf-CCCH	411..437	CDD:279036	16/25 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	528..576		5/47 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..680		10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156526
Domainoid	1	1.000	304	1.000	Domainoid score	I1381
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	604	1.000	Inparanoid score	I946
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004107
OrthoInspector	1	1.000	-	-		otm40880
orthoMCL	1	0.900	-	-		OOG6_105901
Panther	1	1.100	-	-	LDO	PTHR13139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3350
SonicParanoid	1	1.000	-	-		X2848
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.920