DRSC/TRiP Functional Genomics Resources

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Protein Alignment roq and Rc3h1

DIOPT Version :9

Sequence 1:NP_001261940.1 Gene:roq / 39818 FlyBaseID:FBgn0036621 Length:819 Species:Drosophila melanogaster
Sequence 2:NP_001020123.1 Gene:Rc3h1 / 381305 MGIID:2685397 Length:1130 Species:Mus musculus


Alignment Length:670 Identity:356/670 - (53%)
Similarity:425/670 - (63%) Gaps:72/670 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MPIQAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYNRQCPFDQTVIVSDIDNLP 65
            ||:|||.|||||:||||...|..:.|.|:|||||||:||:||..|:.:.||||||.|.:||:.||
Mouse     1 MPVQAPQWTDFLSCPICTQTFDETIRKPISLGCGHTVCKMCLNKLHRKACPFDQTTINTDIELLP 65

  Fly    66 INHALLQLVKDSELLELAPPPPSVQKLEPEHLKCYQLGQRCIEELALHLKSFLNLNGNG------ 124
            :|.||||||.    .::....|.......|..|.|:..::|:|||||:||...:..|.|      
Mouse    66 VNSALLQLVG----AQIPEQQPITLCSGVEDTKHYEEAKKCVEELALYLKPLSSARGVGLNSTTQ 126

  Fly   125 NLLTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWAAVRTRG 189
            ::|:|||.|||||||:|||:|||||:||:|||||||||||||||||||||||||||||||||.||
Mouse   127 SVLSRPMQRKLVTLVHCQLVEEEGRIRAMRAARSLGERTVTELILQHQNPQQLSSNLWAAVRARG 191

  Fly   190 CQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLYRASCFK 254
            |||||||||||.|||||||||:||||||||||:||||||||:|||||||||||||||||||||||
Mouse   192 CQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFK 256

  Fly   255 VSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKSHMQSII 319
            |:||:.||||||||||||||:|||||||:||||||.||||||||:|||||||||..|||||||||
Mouse   257 VTKRDEDSSLMQLKEEFRTYEALRREHDSQIVQIAMEAGLRIAPDQWSSLLYGDQSHKSHMQSII 321

  Fly   320 DKLQTPSSFAQSVQELVIALQRTSDPAKLSSLHHHLKYLANIDPCAEVAP--WSVLAEALDAVRH 382
            ||||||:|||||||||.||||||.|||.|:.|..||:.||||||..:..|  |..|...|.|||.
Mouse   322 DKLQTPASFAQSVQELTIALQRTGDPANLNRLRPHLELLANIDPSPDAPPPTWEQLENGLVAVRT 386

  Fly   383 SVVGLVNFLQHHGVRKAQDGISGGGSGGTTNSNP----KYKISLCRDLNVRRVCPRGSSCTFAHS 443
            .|.|||:::|:|..:            |.....|    |||..:|||:..|..||||:|||||||
Mouse   387 VVHGLVDYIQNHSKK------------GADQQQPPQHSKYKTYMCRDMKQRGGCPRGASCTFAHS 439

  Fly   444 QEEVERYRARNRGKHMKTPLALQGPPAVGVGAIKKP-LGEQEGPPLGN-MPPMLPMSPMHYMGS- 505
            |||:|::|..|:....:.||:........||....| |.::....|.| .||.|| :.:...|| 
Mouse   440 QEELEKFRKMNKRLVPRRPLSASLGQLNEVGLPSAPILSDESAVDLSNRKPPALP-NGIASSGST 503

  Fly   506 -----PRGYLDPSLGLSPGGGLPPSHHSPITRLIVPSRYDSRFSGFGGGTPRI--PSPREYQANP 563
                 ||| .|||...|                :.|.:.|...|...|..|.:  .:|:...|.|
Mouse   504 VTQLIPRG-TDPSFDSS----------------LKPVKLDHLSSSAPGSPPDLLESAPKSISALP 551

  Fly   564 V--------APTQRNANPPNFSVNSNLHKGYMLPASGGDVFH-----LANPWEQAYLAQQQH--- 612
            |        .||.....|....:........:.||...||::     .|..:|.|...|..:   
Mouse   552 VNPHPVPPRGPTDLPPMPVTKPIQMVPRGSQLYPAQQADVYYQDPRGSAPAFETAPYQQGMYYTP 616

  Fly   613 PPQHPQQQQPPSSKPNPSRP 632
            ||...:..:||.|.|.|..|
Mouse   617 PPCVSRFVRPPPSAPEPGPP 636

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
roqNP_001261940.1 zf-RING_5 13..55 CDD:291308 23/41 (56%)
zf-CCCH 418..444 CDD:279036 16/25 (64%)
Rc3h1NP_001020123.1 RING 14..52 CDD:214546 20/37 (54%)
HEPN-N. /evidence=ECO:0000269|PubMed:25697406 128..176 40/47 (85%)
ROQ. /evidence=ECO:0000269|PubMed:25026077 177..326 134/148 (91%)
HEPN-C. /evidence=ECO:0000269|PubMed:25697406 327..399 41/71 (58%)
zf-CCCH 414..440 CDD:279036 16/25 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..567 22/91 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 722..750
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1100..1130
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846934
Domainoid 1 1.000 304 1.000 Domainoid score I1375
eggNOG 1 0.900 - - E1_KOG3161
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 611 1.000 Inparanoid score I915
Isobase 1 0.950 - 0 Normalized mean entropy S5168
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0004107
OrthoInspector 1 1.000 - - otm42953
orthoMCL 1 0.900 - - OOG6_105901
Panther 1 1.100 - - O PTHR13139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3350
SonicParanoid 1 1.000 - - X2848
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.730

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