DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment roq and Rc3h2

DIOPT Version :9

Sequence 1:	NP_001261940.1	Gene:	roq / 39818	FlyBaseID:	FBgn0036621	Length:	819	Species:	Drosophila melanogaster
Sequence 2:	NP_001094061.1	Gene:	Rc3h2 / 319817	MGIID:	2442789	Length:	1187	Species:	Mus musculus

Alignment Length:	784	Identity:	364/784 - (46%)
Similarity:	450/784 - (57%)	Gaps:	145/784 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPIQAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYNRQCPFDQTVIVSDIDNLP 65
            ||:||..||:||:||||.|||..:...|:||||.||:||.||..|:.:.||||||.|.:|||.||
Mouse     1 MPVQAAQWTEFLSCPICYNEFDENVHKPISLGCSHTVCKTCLNKLHRKACPFDQTAINTDIDVLP 65

  Fly    66 INHALLQLVKDSELLELAPPPPSVQKLEPEHL---KCYQLGQRCIEELALHLKSFLNLNG----N 123
            :|.||||||        ....|..|.::..:|   |.|::.::|:|:|||:||......|    |
Mouse    66 VNFALLQLV--------GAQVPDHQSIKLSNLGENKHYEVAKKCVEDLALYLKPLSGGKGVASLN 122

  Fly   124 GNLLTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWAAVRTR 188
            .:.|:|||.|||||||||||:||||||||:|||||||||||||||||||||||||:|||||||.|
Mouse   123 QSALSRPMQRKLVTLVNCQLVEEEGRVRAMRAARSLGERTVTELILQHQNPQQLSANLWAAVRAR 187

  Fly   189 GCQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLYRASCF 253
            ||||||||||||.|||||||||:||||||||||:||||||||:||||||||||||||||||||||
Mouse   188 GCQFLGPAMQEEALKLVLLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCF 252

  Fly   254 KVSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKSHMQSI 318
            ||:||:.||||||||||||:|:|||||||||||.||.||||||:|||||||||||:.||||||||
Mouse   253 KVTKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWSSLLYGDLAHKSHMQSI 317

  Fly   319 IDKLQTPSSFAQSVQELVIALQRTSDPAKLSSLHHHLKYLANIDPCAE-VAP-WSVLAEALDAVR 381
            |||||:|.|||:|||||.|.||||.|||.|:.|..||:.||||||..: |:| |..|..|:.||:
Mouse   318 IDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHLELLANIDPNPDAVSPTWEQLENAMVAVK 382

  Fly   382 HSVVGLVNFLQHHGVRKAQDGISGGGSGGTTNSNPKYKISLCRDLNVRRVCPRGSSCTFAHSQEE 446
            ..|.|||:|:|::. ||       |........|.|||.|:||||..:..||||::|||||||||
Mouse   383 TVVHGLVDFIQNYS-RK-------GHETPQPQPNSKYKTSMCRDLRQQGGCPRGTNCTFAHSQEE 439

  Fly   447 VERYRARNRGKHMKTPLALQGPP---AVGV--------GAIKKPLGEQE---------------- 484
            :|:||.||:    |....::..|   .|||        |.:...:|..|
Mouse   440 LEKYRLRNK----KMSATVRTFPLLNKVGVNSTVTTTAGNVISVIGSTETTGKIVASTNGISNTE 500

  Fly   485 ---------------------------GPPLGNMPPMLPMSPMHYMGS-PRGYLDPSLGLSPG-- 519
                                       |....|..|.......:.:|| |:..:..:...|.|
Mouse   501 SSVSQLIPRGTDSAVRTLETVKKVGKVGTNAQNAGPSAESVSENKIGSPPKTPVSNAAATSAGPS 565

  Fly   520 ------GGLPPSHHSPITRLIVPSRYDSRFSGFGG-------GTPRIPSPREYQANPVAPTQRNA 571
                  ..|||.....:||:.|..::......|..       ..|:.|....|...|..|.....
Mouse   566 NFGTELNSLPPKSSPFLTRVPVYPQHSESIQYFQDPRTQIPFEVPQYPQTGYYPPPPTVPAGVTP 630

  Fly   572 NPPNFSVNSNLHKGYMLPAS--GGDVFHLANPWEQAYLAQQQHPPQHPQQQQP----PSS----- 625
            ..|.|..:||:.:..:.|||  ..|.:...:|.::...:..|.||  |||..|    ||.
Mouse   631 CVPRFVRSSNVPESSLPPASMPYADHYSTFSPRDRMNSSPYQPPP--PQQYGPVPPVPSGMYAPV 693

  Fly   626 ------------------KPNPSRPLSILPATA-DTSFFEK------------KPPNS--VSIDL 657
                              :.|...|:.::.::. .||..|:            :|||.  .::.|
Mouse   694 YDSRRIWRPAMYQRDDIIRSNSLPPMDVMHSSVYQTSLRERYNSLDGYYSVACQPPNDPRTTVPL 758

  Fly   658 DRVP 661
            .|.|
Mouse   759 PREP 762

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
roq	NP_001261940.1	zf-RING_5	13..55	CDD:291308	23/41 (56%)
roq	NP_001261940.1	zf-CCCH	418..444	CDD:279036	16/25 (64%)
Rc3h2	NP_001094061.1	mRING-HC-C3HC3D_Roquin	11..54	CDD:319552	24/42 (57%)
		modified RING-HC finger (C3HC3D-type)	14..53	CDD:319552	21/38 (55%)
		HEPN-N. /evidence=ECO:0000250\|UniProtKB:Q9HBD1	91..170		50/78 (64%)
		ROQ. /evidence=ECO:0000250\|UniProtKB:Q9HBD1	171..325		136/153 (89%)
		ROQ_II	268..323	CDD:375812	47/54 (87%)
		HEPN-C. /evidence=ECO:0000250\|UniProtKB:Q9HBD1	326..396		39/69 (57%)
		CTH1	<393..>500	CDD:227395	39/118 (33%)
		zf-CCCH	411..436	CDD:366217	15/24 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	527..571		8/43 (19%)
		PTZ00449	<535..796	CDD:185628	47/230 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..677		9/38 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846935
Domainoid	1	1.000	304	1.000	Domainoid score	I1375
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	611	1.000	Inparanoid score	I915
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004107
OrthoInspector	1	1.000	-	-		otm42953
orthoMCL	1	0.900	-	-		OOG6_105901
Panther	1	1.100	-	-	LDO	PTHR13139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3350
SonicParanoid	1	1.000	-	-		X2848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920