Protein Alignment roq and rle-1

DIOPT Version :9

• Sequence 1: NP_001261940.1
• Gene: roq / 39818
• FlyBaseID: FBgn0036621
• Length: 819
• Species: Drosophila melanogaster
• Sequence 2: NP_001366782.1
• Gene: rle-1 / 176525
• WormBaseID: WBGene00010923
• Length: 952
• Species: Caenorhabditis elegans
• Alignment Length: 893
• Identity: 266/893 - (29%)
• Similarity: 367/893 - (41%)
• Gaps: 272/893 - (30%)

  Fly     4 QAPSWTDFLNCPICCNEFAASQRCPVSLGCGHTICKLCLTTLYN--RQCPFDQTVIVSDIDNLPI 66
            |...|.:.|.|.||...|..: ..||||.|||.||:.|.....|  :.||.|...........|.
 Worm     6 QGGQWQEVLCCSICNRHFNET-FLPVSLICGHVICRKCAEKPENQTKPCPHDDWKTTHSPSEYPN 69

  Fly    67 NHALLQLVKDSELLELAPPPPSVQKLEPEHLKCYQL------GQRCIEELALHLKSFL---NLNG 122
            |.|||.::...:                   :|..|      .::.:::|::.:..|.   :...
 Worm    70 NVALLSVIFPRK-------------------QCMTLSGAVSEAEKRVDQLSIQIAKFFREADSER 115

  Fly   123 NGNL----LTRPMLRKLVTLVNCQLMEEEGRVRALRAARSLGERTVTELILQHQNPQQLSSNLWA 183
            .|.:    ::|.:.||::.|:..|..|.:||::.|:..|.:.||.:.|:||..|:...:||.||:
 Worm   116 GGTVSSREISRTLQRKVLALLCYQWREVDGRLKTLKMCRGISERVMIEIILSIQSNTHVSSQLWS 180

  Fly   184 AVRTRGCQFLGPAMQEEVLKLVLLALEEGSALSRKVLVMFVVQRLEPKFPQASKTSIGHVVQLLY 248
            |||.|||||||||||::||:|:|:.||.|..::||.|||:|||.|...:||.|||.:||||||||
 Worm   181 AVRARGCQFLGPAMQDDVLRLILMTLETGECIARKNLVMYVVQTLASDYPQVSKTCVGHVVQLLY 245

  Fly   249 RASCFKVSKREADSSLMQLKEEFRTYDALRREHDAQIVQIATEAGLRIAPEQWSSLLYGDVMHKS 313
            |||||.|.||:.:|||||||||||||::||||||:||||||.|:||||.|:|||:|||.|..|:|
 Worm   246 RASCFNVLKRDGESSLMQLKEEFRTYESLRREHDSQIVQIAFESGLRIGPDQWSALLYADQSHRS 310

  Fly   314 HMQSIIDKLQTPSSFAQSVQEL-VIALQRTS--DPAKLSSLHHHLKYLANIDPCAEV-------- 367
            ||||||||||:.:|:.|.|:|| .:|..:||  .||       :..:|..:.||.|.
 Worm   311 HMQSIIDKLQSKNSYQQGVEELRALAGSQTSMLVPA-------YRYFLTQVIPCLEFFAGIEHED 368

  Fly   368 APWSVLAEALDAVRHSVVGLVNFLQHHGVRKAQ-------------DGISGGGSGGTTNS----- 414
            ....::.:||..:|   :.|........:||..             .|..|||.||:..:
 Worm   369 TSMRMIGDALHQIR---ILLKLHCSQDDLRKMPKEERRGVILQAEVPGGMGGGPGGSGGAEAGRI 430

  Fly   415 ---NPKYKISLCRDLNVRRVCPRGSSCTFAHSQEEVERYRARNRGKHMKTPLALQG-----PPAV 471
               :|.|........::.|..|:.:|    |:..:....:.|.:...|..|....|     ||.:
 Worm   431 GGLHPLYSQIDETGRSISRTNPKDNS----HNSPQTPPKQPRQKRYQMGIPPNRMGYSSDAPPFI 491

  Fly   472 GVGAIKKPLGEQEGPP-LGNMPPMLPMSPMHYMGSPRGYLDPSLGLSPGGGLPPSHHSPITRLIV 535
                   |..:|:.|| ..|...:    |..:.|..:           .|..||....|:..||
 Worm   492 -------PSHQQQPPPQFFNSQHL----PQRFRGGRQ-----------RGAPPPPPPQPMPMLI- 533

  Fly   536 PSRYDSRFSGFGGGTPRIPSPREYQANPVAPTQR---NANPPNFSV-NSNLHKGYMLPASGGDVF 596
              .||            :|.....||..|.....   |..|....: .|..|    ||  ||.|.
 Worm   534 --GYD------------MPGAPMMQATEVLTADGQMVNGTPQRVVIMQSPTH----LP--GGPVV 578

  Fly   597 HLANPWEQAYLAQQQHPPQHPQQQQP------PSSKPNPSRPLSILPATADTSFFEKKPPNSVSI 655
            .:..        ||..||  ||...|      |.....||.|:.:             |||::
 Worm   579 MIPQ--------QQMVPP--PQSMTPVGGPMGPMGPMTPSIPVQV-------------PPNTM-- 618

  Fly   656 DLDRVPEVNVDAVPLFRRSNNNHNNNNSNSHNNNNNNHGSSLLFWNNTGKDSANFVRSDSILDDD 720
                                                        |..|.
 Worm   619 --------------------------------------------WTATS---------------- 623

  Fly   721 ASTFDVPTGSSMLSIYGPICPK---------SSTTGN-WNNFDLGYGGFKSDRNDSFNANKQQQP 775
                  ||||   .||....|.         .||.|| :..||.|.||.
 Worm   624 ------PTGS---VIYPAASPPGQPPHTIWIQSTDGNMFPMFDRGSGGM---------------- 663

  Fly   776 MWGRKPQLMSEDSFEGGIDSGMML----QLEKNL---VDIVDPDDSGI 816
            :||  |..|..:|   |.|:..:|    ::.|.|   .|..||:|.||
 Worm   664 VWG--PGTMLRES---GADAEQLLAKRYEILKRLQPSEDDDDPEDGGI 706

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
roq	NP_001261940.1	zf-RING_5	13..55	CDD:291308	18/43 (42%)
		zf-CCCH	418..444	CDD:279036	5/25 (20%)
rle-1	NP_001366782.1	RING_Ubox	13..56	CDD:418438	18/43 (42%)
		ROQ_II	266..321	CDD:408185	42/54 (78%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	185	1.000	Domainoid score	I2021
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5168
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004107
OrthoInspector	1	1.000	-	-		oto17306
orthoMCL	1	0.900	-	-		OOG6_105901
Panther	1	1.100	-	-	LDO	PTHR13139
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3350
SonicParanoid	1	1.000	-	-		X2848
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.890