DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4842 and Hpgd

DIOPT Version :9

Sequence 1:	NP_648885.1	Gene:	CG4842 / 39817	FlyBaseID:	FBgn0036620	Length:	259	Species:	Drosophila melanogaster
Sequence 2:	NP_077366.2	Gene:	Hpgd / 79242	RGDID:	620087	Length:	266	Species:	Rattus norvegicus

Alignment Length:	247	Identity:	80/247 - (32%)
Similarity:	123/247 - (49%)	Gaps:	10/247 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDLAGKNVVYLGGFGGIGQKCVQELLQRPIK-ALAIFDLNANEQLLAKWKSQHPDTDVFYHKLDI 64
            |.:.||..:..|...|||:...:.||....| ||..::|....:..|....|.......:.:.|:
  Rat     1 MHVNGKVALVTGAAQGIGKAFTEALLLHGAKVALVDWNLETGVKCKAALDEQFEPQKTLFIQCDV 65

  Fly    65 TQKSDIDAAYKATAERFGHFDVVVNGSGLMNDRLVELTIQINLLGVINSTLTALEYMDKAKGGKG 129
            ..:..:...::...:.||..|::||.:|:.|::..|.|:||||:.||:.|...|:||.|..||:|
  Rat    66 ADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNGGEG 130

  Fly   130 GLIVNISSVAGLQPTAIMAIYSAAKTGVTTFTRAMANPYFYAHSGVGFLTICPGFTDTGLLEDI- 193
            |:|:||||:|||.|.|...:|.|:|.|:..|||:.|.......|||....|||||..|.:||.|
  Rat   131 GIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILESIE 195

  Fly   194 -----GNKTTFTYDTPMLAMFNRVKRQKAEDCARNLVSAIE-TSKNGTVLML 239
                 |....:|.....:..|..:....|  .|..|::.|| .:.||.::.:
  Rat   196 KEENMGQYIEYTDQIKAMMKFYGILDPSA--IANGLINLIEDDALNGAIMKI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4842	NP_648885.1	NADB_Rossmann	6..247	CDD:304358	78/242 (32%)
CG4842	NP_648885.1	adh_short	6..194	CDD:278532	68/194 (35%)
Hpgd	NP_077366.2	ADH_SDR_c_like	6..254	CDD:187584	78/242 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344850
Domainoid	1	1.000	142	1.000	Domainoid score	I4569
eggNOG	1	0.900	-	-		E2759_KOG4169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	150	1.000	Inparanoid score	I4290
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44427
orthoMCL	1	0.900	-	-		OOG6_100916
Panther	1	1.100	-	-	O	PTHR44229
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.760