DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ringer and Tppp

DIOPT Version :9

Sequence 1:	NP_001246792.1	Gene:	ringer / 39813	FlyBaseID:	FBgn0266417	Length:	192	Species:	Drosophila melanogaster
Sequence 2:	NP_878259.1	Gene:	Tppp / 72948	MGIID:	1920198	Length:	218	Species:	Mus musculus

Alignment Length:	203	Identity:	82/203 - (40%)
Similarity:	115/203 - (56%)	Gaps:	21/203 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AANGSPSPAPTPEVPATELAQLALEDE---------PKVS-FSDQFKAFSKFGDSKSDGKLITLS 60
            |||.:|..:|..  ||....:|:||.|         |::| ..:.|:.|:..||:::.||.:...
Mouse    11 AANKTPPKSPGD--PARAAKRLSLESEGANEGATAAPELSALEEAFRRFAVHGDTRATGKEMHGK 73

  Fly    61 QSDKWMKQAKVID-KKITTTDTGIHFKKFKAMK---ISLSDYNKFLDDLAKTK-KVELSE--IKQ 118
            ...|..|...||| |.:|.||..|.|.|.|...   |:...:.:.|::|||.: |.:.||  :::
Mouse    74 NWSKLCKDCHVIDGKNVTVTDVDIVFSKIKGKSCRTITFEQFQEALEELAKKRFKDKSSEEAVRE 138

  Fly   119 --KLASCGAPGVVSVSAGKAAAAVDRLTDTSKYTGSHKERFDASGKGKGIAGRRNVVDGSGYVSG 181
              :|....||.:..|:...::..|.|||||||:|||||||||.||||||.|||.::||.||||.|
Mouse   139 VHRLIEGRAPVISGVTKAVSSPTVSRLTDTSKFTGSHKERFDQSGKGKGKAGRVDLVDESGYVPG 203

  Fly   182 YQHKDTYD 189
            |:|..|||
Mouse   204 YKHAGTYD 211

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ringer	NP_001246792.1	p25-alpha	39..184	CDD:368481	65/153 (42%)
Tppp	NP_878259.1	Mediates interaction with LIMK1. /evidence=ECO:0000250\|UniProtKB:O94811	1..115		33/105 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46		11/36 (31%)
		p25-alpha	51..206	CDD:368481	65/154 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..192		22/25 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167834634
Domainoid	1	1.000	116	1.000	Domainoid score	I5926
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H21389
Inparanoid	1	1.050	122	1.000	Inparanoid score	I4733
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52260
OrthoDB	1	1.010	-	-		D1317210at2759
OrthoFinder	1	1.000	-	-		FOG0002323
OrthoInspector	1	1.000	-	-		otm44062
orthoMCL	1	0.900	-	-		OOG6_102553
Panther	1	1.100	-	-	O	PTHR12932
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1531
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910