Protein Alignment Pdh and Hpgd

DIOPT Version :10

• Sequence 1: NP_524105.2
• Gene: Pdh / 39812
• FlyBaseID: FBgn0011693
• Length: 278
• Species: Drosophila melanogaster
• Sequence 2: NP_077366.2
• Gene: Hpgd / 79242
• RGDID: 620087
• Length: 266
• Species: Rattus norvegicus
• Alignment Length: 261
• Identity: 96/261 - (36%)
• Similarity: 147/261 - (56%)
• Gaps: 29/261 - (11%)

  Fly    18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVKLRAA----HPTQSVMIIK 78
            |...||.|:|||.|.|||...::.||..| ||||::|.  |||..||.:||    ...|..:.|:
  Rat     1 MHVNGKVALVTGAAQGIGKAFTEALLLHG-AKVALVDW--NLETGVKCKAALDEQFEPQKTLFIQ 62

  Fly    79 MDVANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYMGKDNG 143
            .|||::|.:..|:.::...||.:||:||.||:.|:|:.::||.:||..:|:.|...|.||.|.||
  Rat    63 CDVADQKQLRDTFRKVVDHFGRLDILVNNAGVNNEKNWEQTLQINLVSVISGTYLGLDYMSKQNG 127

  Fly   144 GKGGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVTVCPGATMTDM-- 206
            |:|||::|:||:.||.|:...|||.|:|.|||.|||..|......:||::...:|||...|.:
  Rat   128 GEGGIIINISSIAGLMPVAQQPVYCASKHGIIGFTRSAAMAANLMKSGVRLNVICPGFVKTPILE 192

  Fly   207 ----------FTNFTEKIIFPETSDETYRILDRLNKQSAADVSRCILNVLEKDK-NGAVYVIEGK 260
                      :..:|::|   :...:.|.|||      .:.::..::|::|.|. |||:..|...
  Rat   193 SIEKEENMGQYIEYTDQI---KAMMKFYGILD------PSAIANGLINLIEDDALNGAIMKITAS 248

  Fly   261 R 261
            :
  Rat   249 K 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pdh	NP_524105.2	Rossmann-fold NAD(P)(+)-binding proteins	23..259	CDD:473865	94/252 (37%)
Hpgd	NP_077366.2	ADH_SDR_c_like	6..254	CDD:187584	94/256 (37%)