DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdh and hpgd

DIOPT Version :9

Sequence 1:	NP_524105.2	Gene:	Pdh / 39812	FlyBaseID:	FBgn0011693	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_001313470.1	Gene:	hpgd / 565975	ZFINID:	ZDB-GENE-080728-2	Length:	261	Species:	Danio rerio

Alignment Length:	246	Identity:	80/246 - (32%)
Similarity:	131/246 - (53%)	Gaps:	7/246 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVK--LRAAHPTQSVMIIKMD 80
            ||..||.|:|||||.|||..|.::||..| ||||::||..::.|..|  |.......:.:.|:.|
Zfish     1 MSLHGKTALVTGGAQGIGRAVVEELLQNG-AKVALVDLNQSVGEECKSDLDDQFGEDNCIFIQCD 64

  Fly    81 VANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYMGKDNGGK 145
            |.:.:.:...:......||.:|||:|.|||.|:|:.::|:.|||..:|..|..||.:|.|:.|.:
Zfish    65 VTDGEKLGDAFRNTVDRFGRLDIVINNAGINNEKNWEKTIEVNLTSVIKGTYLALEHMSKEYGKQ 129

  Fly   146 GGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVTVCPGATMTDMFTNF 210
            ||.::|:||:.........|||.|||.|:|.|:|.:|:.......|::...:||....|.:....
Zfish   130 GGAIINVSSMAAFLHSPHQPVYTATKYGVIGFSRAMADASEQGNYGVRINALCPAFVDTQLLQTV 194

  Fly   211 TEKII---FPETSDETYRILDRLNKQSAADVSRCILNVL-EKDKNGAVYVI 257
            ..:..   |.:..|:..:.:|:......:.::..:|.:: ::..||||..|
Zfish   195 EHEETMGKFVKYKDDFKQRMDKYGVLKPSLIAEGMLRLITDESLNGAVMKI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdh	NP_524105.2	NADB_Rossmann	23..259	CDD:304358	77/241 (32%)
Pdh	NP_524105.2	adh_short	23..214	CDD:278532	68/192 (35%)
hpgd	NP_001313470.1	ADH_SDR_c_like	6..254	CDD:187584	77/241 (32%)
hpgd	NP_001313470.1	adh_short	6..198	CDD:278532	68/192 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585842
Domainoid	1	1.000	134	1.000	Domainoid score	I4954
eggNOG	1	0.900	-	-		E2759_KOG4169
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4534
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6395
orthoMCL	1	0.900	-	-		OOG6_100916
Panther	1	1.100	-	-	O	PTHR44229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7321
SonicParanoid	1	1.000	-	-		X2961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.790