DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pdh and zgc:56585

DIOPT Version :9

Sequence 1:	NP_524105.2	Gene:	Pdh / 39812	FlyBaseID:	FBgn0011693	Length:	278	Species:	Drosophila melanogaster
Sequence 2:	NP_956621.2	Gene:	zgc:56585 / 393297	ZFINID:	ZDB-GENE-040426-1084	Length:	270	Species:	Danio rerio

Alignment Length:	247	Identity:	83/247 - (33%)
Similarity:	137/247 - (55%)	Gaps:	9/247 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 MSFRGKNAVVTGGAGGIGLQVSKQLLAAGAAKVAIIDLQDNLEEFVK--LRAAHPTQSVMIIKMD 80
            |..:.|.|||||.|.|:|....:.|:..| :|||:||:..:|.|.:|  |...:..........|
Zfish     1 MDLKDKVAVVTGAAQGLGRSFVEILMKNG-SKVALIDVNKSLGEELKTTLNKEYGPNRAEFYTAD 64

  Fly    81 VANKKGVEATYEEIAKTFGNIDIVVNVAGIFNDKDVQRTLLVNLGGIINSTLSALPYMGKDNGGK 145
            |::::..:...::|.:.||.|||:.|.|||.|:|..::|:.:||||::..|..||.||.|:|||.
Zfish    65 VSSEEDFKGVLKKIVEQFGQIDIMCNNAGIINEKHWEKTIAINLGGVVRGTYLALEYMKKENGGS 129

  Fly   146 GGIVVNMSSVVGLDPMFIIPVYGATKAGIINFTRCLANEKYYQRSGIKFVTVCPGATMTDMFT-- 208
            ||::||::|:.||.|:.:.|:|.|||.|::.|:|.:|....:...|::...:||....|.:.:
Zfish   130 GGVIVNVASMAGLGPLPVAPIYTATKHGVVGFSRAMAVVSKFSNYGVRINVLCPWFVKTSLLSLL 194

  Fly   209 NFTEKI-IFPETSDETYRILDRLNKQSAADVSRCILNVLEKD--KNGAVYVI 257
            |..|.. .|.:..:.|..:::.........|::..| ||.||  |:|...:|
Zfish   195 NSEEHTGSFSQMKEITEMLMESEGCLEVDVVAKAFL-VLVKDESKDGEALMI 245

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pdh	NP_524105.2	NADB_Rossmann	23..259	CDD:304358	82/242 (34%)
Pdh	NP_524105.2	adh_short	23..214	CDD:278532	71/194 (37%)
zgc:56585	NP_956621.2	ADH_SDR_c_like	6..254	CDD:187584	82/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585837
Domainoid	1	1.000	134	1.000	Domainoid score	I4954
eggNOG	1	0.900	-	-		E2759_KOG4169
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H134459
Inparanoid	1	1.050	136	1.000	Inparanoid score	I4534
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1053465at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm6395
orthoMCL	1	0.900	-	-		OOG6_100916
Panther	1	1.100	-	-	O	PTHR44229
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7321
SonicParanoid	1	1.000	-	-		X2961
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.790